Reviewed, UniProtKB/Swiss-Prot Q46Y48 (HIS81_RALEJ)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	Reut_A2574

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153428
Amino acid modifications
	Modified residue	235	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46Y48-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 0BBC3BE84C51C3BD	FASTA	376	40,148
	10 20 30 40 50 60 MAEQGKQGGK VPFGPDYVRA ISPYIAGKPI SEVAREFGLD EAGIVKLASN ENPLGMPESA 70 80 90 100 110 120 KHAAAAAIAE LGRYPDSNGF ELKAALSTKL GVPQDWLTLG NGSNDILELA AHALVTPGQS 130 140 150 160 170 180 IVYAEYSFAV YALATQEIGA RAIVVKARDY GHDLDAMAAA ITSDTRLVFI ANPNNPTGTF 190 200 210 220 230 240 VPAAALETFL AKVPAEVVVV LDEAYNEYLD DDQQYDSVAW VRRYPNLLVS RTFSKAYGLA 250 260 270 280 290 300 GLRIGYAVAQ PELTDLLNRI RQPFNVNSVA QAAAVAALGD TAFLQRSAEL NRAGKAQLVE 310 320 330 340 350 360 AFSRLGLEFV ASSGNFVLVR VGDDDDAGAR VNVALLRQGV IVRPVGNYGM PRWLRVTIGL 370 PDENAAFIAA LERALK

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000090 Genomic DNA. Translation: AAZ61935.1.
RefSeq	YP_296779.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3609598.
GenomeReviews	Gene locus Reut_A2574 in contig CP000090_GR.
KEGG	reu:Reut_A2574.
NMPDR	fig|264198.3.peg.3328.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q46Y48.
OMA	Q46Y48. PLGMPKS.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A2574-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_RALEJ

Accession

Primary (citable) accession number: Q46Y48

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)