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Q46XD8

- SYL_CUPPJ

UniProt

Q46XD8 - SYL_CUPPJ

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Protein

Leucine--tRNA ligase

Gene
leuS, Reut_A2834
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-2881-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Reut_A2834
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Leucine--tRNA ligaseUniRule annotationPRO_0000334800Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A2834.

Structurei

3D structure databases

ProteinModelPortaliQ46XD8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotationAdd
BLAST
Motifi636 – 6405"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46XD8-1 [UniParc]FASTAAdd to Basket

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MQDKYLPSAV EQAAQQHWQA IDAYRVPEHA TGPDGKEKPK FYACSMLPYP    50
SGKLHMGHVR NYTINDVMAR YLRMNGNNVL MPMGWDAFGM PAENAALNNG 100
VAPAAWTYDN IAYMKKQMQS MGLAIDWSRE VATCSPDYYR WNQWLFLKML 150
EKGIAYRKTG TVNWDPVDQT VLANEQVIDG RGWRSGAIVE KREIPMYYLR 200
ITDYAEELLG DLDGLGWPER VKIMQQNWIG KSVGVRFAFK HDIEGDDGQL 250
INDGKLYVFT TRADTIMGVT FCAVAAEHPL ATHAAANNPE LAAFIDECKH 300
GSVMEADMAT MEKKGMPTGL QVTHPLTGEQ VDVWVGNYVL MSYGDGAVMG 350
VPAHDERDFA FANKYKLPIR QVIDVKGQPY STEAWQEWYG DKENGVCIES 400
GKYNGLGYLA AVEAIAADLG AMGLGEKKIT WRLRDWGISR QRYWGTPIPL 450
IHCDSCGVVP VPEQDLPVVL PEDLVPDGTG NPLNKDPRFL QCSCPSCGKP 500
ARRETDTMDT FIDSCWYYMR YTCPDAATMV DARNDYWMPM DQYIGGIEHA 550
ILHLLYARFW TKVMRDLGLV KFDEPFTNLL TQGMVLNETF YREDAAGKKT 600
WYNPADVDVQ TDDRGRPVGA TLKADGQPVV IGGVEKMSKS KNNGIDPQAL 650
IDQHGADTAR LFVMFAAPPE QQLEWSGSGV EGASRFLRRV WNYGFANAAA 700
VRDGAGAAPT ADDADLRREI HGVLKQANYD YQRIQYNTVV SATMKMLNAL 750
EDAKNASPVA RRECFGILLR VLYPVVPHIT HGLWDALGYA TQYGDLLDAP 800
WPQVDEGALV RTEIEMVLQI NGKVRGSVTV PADADRAAIE TAAAASETVA 850
KFAEGKAPKK IVVVPGRLVN VVL 873
Length:873
Mass (Da):97,066
Last modified:May 20, 2008 - v2
Checksum:i64987B16A46F6342
GO

Sequence cautioni

The sequence AAZ62195.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62195.1. Different initiation.
RefSeqiYP_297039.2. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62195; AAZ62195; Reut_A2834.
GeneIDi3612136.
KEGGireu:Reut_A2834.
PATRICi20231354. VBIRalEut24049_3510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62195.1 . Different initiation.
RefSeqi YP_297039.2. NC_007347.1.

3D structure databases

ProteinModelPortali Q46XD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A2834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ62195 ; AAZ62195 ; Reut_A2834 .
GeneIDi 3612136.
KEGGi reu:Reut_A2834.
PATRICi 20231354. VBIRalEut24049_3510.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CPIN264198:GIW3-2881-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiSYL_CUPPJ
AccessioniPrimary (citable) accession number: Q46XD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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