Reviewed, UniProtKB/Swiss-Prot Q46X58 (SDHD_RALEJ)

Names and origin

Protein names

Recommended name:
    Probable D-serine dehydratase
    EC=4.3.1.18
Alternative name(s):
    D-serine deaminase
      Short name=DSD

Gene names

Name:	dsdA
Ordered Locus Names:	Reut_A2915

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP MF_01030
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC hydro-lyase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	Probable D-serine dehydratase HAMAP MF_01030		PRO_0000291738
Amino acid modifications
	Modified residue	106	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46X58-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5168A7877E95A088	FASTA	443	46,704
	10 20 30 40 50 60 MVTLSLTPEL LAKLQSRQPL LWVNPRLGQP LPASAPSLEL IAAAEARLAR CAPLMAALFP 70 80 90 100 110 120 ELASSHGQVE SQLMPATGLQ YALGEGAEGA WFIKRDDQLP TAGSIKARGG FHEVLAIAES 130 140 150 160 170 180 IAIEHGMLDP DGDRRVLATE AARKLFSQYS VTVGSTGNLG LSIGVMAAAL GFDAVVHMSA 190 200 210 220 230 240 DAKAWKKDRL RKRGVRVVEH EGDYAQAVAA GREQALGATR CHFVDDERSA LLFFGYAAAA 250 260 270 280 290 300 RHLARQLAEA GRVVDAAHPL FVYLPCGVGG APGGITYGLK ALLGDHVHCF FAEPVASPCV 310 320 330 340 350 360 LVQLASGSDD PVSVYDIGLD NRTDADGLAV GQASHLVSPL MASQLAGVFT VPDDQLYVQL 370 380 390 400 410 420 LALKTSMGVE VEPSAAAGIG GPGWLRDSPE GRAYVRDHGL DMRDATHVIW ATGGSLVPRE 430 440 ELHRFQAYAT ALAHVPGAMH KAA

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000090 Genomic DNA. Translation: AAZ62275.1.
RefSeq	YP_297119.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3610457.
GenomeReviews	Gene locus Reut_A2915 in contig CP000090_GR.
KEGG	reu:Reut_A2915.
NMPDR	fig|264198.3.peg.2697.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q46X58.
OMA	Q46X58. DHPLFVY.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A2915-MON.
Family and domain databases
HAMAP	MF_01030. [Tree]
InterPro	IPR011780. D_Ser_am_lyase. IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
PANTHER	PTHR10314:SF9. D_Ser_am_lyase. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD_RALEJ

Accession

Primary (citable) accession number: Q46X58

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)