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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:Reut_A2953
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002319291 – 231RNA pyrophosphohydrolaseAdd BLAST231

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A2953.

Structurei

3D structure databases

ProteinModelPortaliQ46X20.
SMRiQ46X20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 149Nudix hydrolaseUniRule annotationAdd BLAST144

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066723.
KOiK08311.
OMAiPLDCVIE.
OrthoDBiPOG091H0392.

Family and domain databases

HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiView protein in InterPro
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46X20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDREGFRPN VGIILINARN EVFWGKRIGE HSWQFPQGGI KYGETPEQAM
60 70 80 90 100
YRELHEEIGL LPEHVRIVGR TRDWLRYEVP DKFIRREIRG HYRGQKQIWF
110 120 130 140 150
LLRMAGRDCD VHLRATEHPE FDAWRWSDYW VPLEAVIEFK RDVYQLALTE
160 170 180 190 200
LSRFLNRNPR VPLSPYGVHH GRHGSGQRYA QQPGQPPTLA QRRPLQPVTQ
210 220 230
VAPVAPAAEA VQAVESDAVL PATPAPNPTE S
Length:231
Mass (Da):26,722
Last modified:September 13, 2005 - v1
Checksum:i7893A4082A74D720
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ62313.1.
RefSeqiWP_011299098.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62313; AAZ62313; Reut_A2953.
KEGGireu:Reut_A2953.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRPPH_CUPNJ
AccessioniPrimary (citable) accession number: Q46X20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families