Histidinol-phosphate aminotransferase 2 - Ralstonia eutropha (strain JMP134)

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Reviewed, UniProtKB/Swiss-Prot Q46WL3 (HIS82_RALEJ)

Last modified June 16, 2009. Version 27. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Reut_A3110

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

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Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

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Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 366

366

Histidinol-phosphate aminotransferase 2 HAMAP MF_01023

PRO_0000153429

Amino acid modifications

Modified residue

226

N6-(pyridoxal phosphate)lysine By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q46WL3-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: D979A3B063F852E6
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FASTA

366

39,607

        10         20         30         40         50         60 
MSVVDPSLIE RIIRDDVRAM GAYHVPDSHG LVKLDAMENP YRLPPALRSE LAARLGEVAL 

        70         80         90        100        110        120 
NRYPVPSSEA LRAKLKEVMQ VPAGMEVLLG NGSDEIISML ALAAARPGAK VMAPVPGFVM 

       130        140        150        160        170        180 
YAMSAQFAGL EFVGVPLRAD FTLDRGAMLA AMAEHQPAIV YLAYPNNPTG NLFDAADMEA 

       190        200        210        220        230        240 
IVRAAQGSVC RSLVVVDEAY QPFAQESWMS RLTDFGNLLV MRTVSKLGLA GIRLGYVAGD 

       250        260        270        280        290        300 
PQWLEQLDKV RPPYNVNVLT EATALFALEH VAVLDEQAAQ LRAERSRVAE GMAAHGGVTV 

       310        320        330        340        350        360 
FPSAANFLLA RVPDAAQTFD RLLARKVLIK NVSKMHPLLA NCLRVTVSTP EENAQFLEAF 


AASLQD

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References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000090 Genomic DNA. Translation: AAZ62470.1.

RefSeq

YP_297314.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EUC	X-ray	2.05	A/B	1-366	[»]

ModBase

Search...

Genome annotation databases

GeneID

3609701.

GenomeReviews

Gene locus Reut_A3110 in contig CP000090_GR.

KEGG

reu:Reut_A3110.

NMPDR

fig|264198.3.peg.3550.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

Q46WL3.

OMA

Q46WL3. RIQTIEH.

Enzyme and pathway databases

BioCyc

REUT264198:REUT_A3110-MON.

Family and domain databases

HAMAP

MF_01023.
[Tree]

InterPro

IPR004839. Aminotrans_I/II.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR005861. HisP_aminotrans.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]

Gene3D

G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.

Pfam

PF00155. Aminotran_1_2. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01141. hisC. 1 hit.

PROSITE

PS00599. AA_TRANSFER_CLASS_2. False negative.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

HIS82_RALEJ

Accession

Primary (citable) accession number: Q46WL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families