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Q46WL2

- HISX_CUPPJ

UniProt

Q46WL2 - HISX_CUPPJ

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Protein

Histidinol dehydrogenase

Gene
hisD, Reut_A3111
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei144 – 1441NAD By similarity
Binding sitei205 – 2051NAD By similarity
Binding sitei228 – 2281NAD By similarity
Binding sitei251 – 2511Substrate By similarity
Metal bindingi273 – 2731Zinc By similarity
Binding sitei273 – 2731Substrate By similarity
Metal bindingi276 – 2761Zinc By similarity
Binding sitei276 – 2761Substrate By similarity
Active sitei341 – 3411Proton acceptor By similarity
Active sitei342 – 3421Proton acceptor By similarity
Binding sitei342 – 3421Substrate By similarity
Metal bindingi375 – 3751Zinc By similarity
Binding sitei375 – 3751Substrate By similarity
Binding sitei429 – 4291Substrate By similarity
Metal bindingi434 – 4341Zinc By similarity
Binding sitei434 – 4341Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-3165-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Reut_A3111
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histidinol dehydrogenaseUniRule annotationPRO_0000135826Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A3111.

Structurei

3D structure databases

ProteinModelPortaliQ46WL2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46WL2-1 [UniParc]FASTAAdd to Basket

« Hide

MNATEMENVS IRRLDSSDPR FAQALREVLA FEAGEDEAID RAVAQILADV    50
KDRGDAAVLE YTQRFDRVEA ASMGALEISQ SELEAALEDL EPKRRAALEA 100
AAARVRAYHE KQKIECGSHS WEYTEADGTM LGQKVTPLDR VGIYVPGGKA 150
AYPSSVLMNA IPARVAGVKE IIMVVPTPGG VRNELVLAAA QIAGVDRVFT 200
IGGAQAVGAL AYGTATLPQV DKIVGPGNAY VAAAKRRVFG TVGIDMIAGP 250
SEILVICDGT TDPDWVAMDL FSQAEHDELA QSILLCPDAD YIAQVEASIQ 300
RQLDSMPRRE VIAASISGRG ALIKVRDMEE ACEIANAIAP EHLEISAENP 350
RQWSEKIRHA GAIFLGRYTS ESLGDYCAGP NHVLPTSRTA RFSSPLGVYD 400
FQKRSSLIEV SEGGAQMLGQ IAAELAYGEG LQAHARSAEY RFKRS 445
Length:445
Mass (Da):47,888
Last modified:September 13, 2005 - v1
Checksum:i4E3DF54A378ADE4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62471.1.
RefSeqiYP_297315.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62471; AAZ62471; Reut_A3111.
GeneIDi3611937.
KEGGireu:Reut_A3111.
PATRICi20231936. VBIRalEut24049_3794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62471.1 .
RefSeqi YP_297315.1. NC_007347.1.

3D structure databases

ProteinModelPortali Q46WL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A3111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ62471 ; AAZ62471 ; Reut_A3111 .
GeneIDi 3611937.
KEGGi reu:Reut_A3111.
PATRICi 20231936. VBIRalEut24049_3794.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CPIN264198:GIW3-3165-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiHISX_CUPPJ
AccessioniPrimary (citable) accession number: Q46WL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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