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Reviewed, UniProtKB/Swiss-Prot Q46WL2 (HISX1_RALEJ)

Last modified February 9, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23
Gene names
Name: hisD1
Ordered Locus Names: Reut_A3111
OrganismRalstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]
Taxonomic identifier264198 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

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Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Histidinol dehydrogenase 1 HAMAP MF_01024
PRO_0000135826

Sites

Active site3411Proton acceptor By similarity
Active site3421Proton acceptor By similarity
Metal binding2731Zinc By similarity
Metal binding2761Zinc By similarity
Metal binding3751Zinc By similarity
Metal binding4341Zinc By similarity
Binding site1441NAD By similarity
Binding site2051NAD By similarity
Binding site2281NAD By similarity
Binding site2511Substrate By similarity
Binding site2731Substrate By similarity
Binding site2761Substrate By similarity
Binding site3421Substrate By similarity
Binding site3751Substrate By similarity
Binding site4291Substrate By similarity
Binding site4341Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q46WL2-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 4E3DF54A378ADE4B

FASTA44547,888
        10         20         30         40         50         60 
MNATEMENVS IRRLDSSDPR FAQALREVLA FEAGEDEAID RAVAQILADV KDRGDAAVLE 

        70         80         90        100        110        120 
YTQRFDRVEA ASMGALEISQ SELEAALEDL EPKRRAALEA AAARVRAYHE KQKIECGSHS 

       130        140        150        160        170        180 
WEYTEADGTM LGQKVTPLDR VGIYVPGGKA AYPSSVLMNA IPARVAGVKE IIMVVPTPGG 

       190        200        210        220        230        240 
VRNELVLAAA QIAGVDRVFT IGGAQAVGAL AYGTATLPQV DKIVGPGNAY VAAAKRRVFG 

       250        260        270        280        290        300 
TVGIDMIAGP SEILVICDGT TDPDWVAMDL FSQAEHDELA QSILLCPDAD YIAQVEASIQ 

       310        320        330        340        350        360 
RQLDSMPRRE VIAASISGRG ALIKVRDMEE ACEIANAIAP EHLEISAENP RQWSEKIRHA 

       370        380        390        400        410        420 
GAIFLGRYTS ESLGDYCAGP NHVLPTSRTA RFSSPLGVYD FQKRSSLIEV SEGGAQMLGQ 

       430        440 
IAAELAYGEG LQAHARSAEY RFKRS

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References

[1]"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000090 Genomic DNA. Translation: AAZ62471.1.
RefSeqYP_297315.1.

3D structure databases

SMRQ46WL2. Positions 34-444.
ModBaseSearch...

Genome annotation databases

GeneID3611937.
GenomeReviewsGene locus Reut_A3111 in contig CP000090_GR.
KEGGreu:Reut_A3111.
NMPDRfig|264198.3.peg.3551.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG329596.
OMALDAHKNA.

Enzyme and pathway databases

BioCycREUT264198:REUT_A3111-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH_prok-type.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX1_RALEJ
AccessionPrimary (citable) accession number: Q46WL2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents