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Q46WH2

- Q46WH2_CUPPJ

UniProt

Q46WH2 - Q46WH2_CUPPJ

Protein

Thiol:disulfide interchange protein DsbD

Gene

dsbD

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.UniRule annotation

    Catalytic activityi

    Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.UniRule annotation

    GO - Molecular functioni

    1. electron carrier activity Source: UniProtKB-HAMAP
    2. protein-disulfide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell redox homeostasis Source: UniProtKB-HAMAP
    2. cytochrome complex assembly Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Cytochrome c-type biogenesisUniRule annotation, Electron transportUniRule annotation, Transport

    Keywords - Ligandi

    NADUniRule annotation

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-3205-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiol:disulfide interchange protein DsbDUniRule annotation (EC:1.8.1.8UniRule annotation)
    Alternative name(s):
    Protein-disulfide reductaseUniRule annotation
    Gene namesi
    Name:dsbDUniRule annotation
    Ordered Locus Names:Reut_A3151Imported
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Chromosome 1

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membraneUniRule annotation, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939UniRule annotationAdd
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi143 ↔ 149Redox-activeUniRule annotation
    Disulfide bondi231 ↔ 351Redox-activeUniRule annotation
    Disulfide bondi550 ↔ 553Redox-activeUniRule annotation

    Keywords - PTMi

    Disulfide bondUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi264198.Reut_A3151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46WH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei212 – 23221Helical;UniRule annotationAdd
    BLAST
    Transmembranei258 – 27821Helical;UniRule annotationAdd
    BLAST
    Transmembranei290 – 31021Helical;UniRule annotationAdd
    BLAST
    Transmembranei334 – 35421Helical;UniRule annotationAdd
    BLAST
    Transmembranei375 – 39521Helical;UniRule annotationAdd
    BLAST
    Transmembranei410 – 43021Helical;UniRule annotationAdd
    BLAST
    Transmembranei431 – 45121Helical;UniRule annotationAdd
    BLAST
    Transmembranei467 – 48721Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini488 – 634147ThioredoxinUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thioredoxin family. DsbD subfamily.UniRule annotation
    Contains 1 thioredoxin domain.UniRule annotation

    Keywords - Domaini

    Redox-active centerUniRule annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG4232.
    HOGENOMiHOG000254982.
    KOiK04084.
    OMAiSCIEMEK.
    OrthoDBiEOG69D3B9.

    Family and domain databases

    Gene3Di2.60.40.1250. 1 hit.
    3.40.30.10. 1 hit.
    HAMAPiMF_00399. DbsD.
    InterProiIPR003834. Cyt_c_assmbl_TM_dom.
    IPR028250. DsbDN.
    IPR022910. Thiol_diS_interchange_DbsD.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view]
    PANTHERiPTHR32234. PTHR32234. 1 hit.
    PfamiPF11412. DsbC. 1 hit.
    PF02683. DsbD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF74863. SSF74863. 1 hit.
    PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q46WH2-1 [UniParc]FASTAAdd to Basket

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    MSMGFALLAR SYGAGWARHI AAVLAVMVAW LCLVTGAHAA TEDDFLPPEQ    50
    AFRFAARQID PQTIEVRFDV ASGYYLYRER FAFAARPDTV RLGQPEFPHG 100
    KVKFDETFGK EMETYRDAVV IRLPVQSAPA DGKWSLVVTS QGCADKGLCY 150
    PPMESVYKVG GSPLGNLFAD RPRSEATVPP AASARPGTEA VAPPARLDEN 200
    DRIAGVLASR NLGVVLALFF GLGLLLTFTP CVLPMVPILS SIVVGEHATR 250
    SRALVVSLAY VLGMAVVYTA IGVAAGLLGE GLAAALQTPA VLAAFAALMV 300
    ALSLSMFGLY ELQLPQHWQT RLTATSNRRQ GGQVIGAAAM GAISALIVGP 350
    CVTAPLAGAL AYIAQTRDAV TGGTALLAMA LGMGVPLVLV GVGAGNLLPR 400
    AGHWMEATKR FFGFLLLGVA IWMVTPVLPA WLTMALWAAL LLVAAVFLGA 450
    FDALGAEARG LARLGKGLGV LAALAGAILL LGLASGGRDP LQPLAHLSLA 500
    RVAGGGAETA AGPQSVRFER VRSVAELDAR VAQAAAAGKP VLLDFYADWC 550
    VSCKEMEHLT FTDAKVRARM SEIVLLQADV TANNADDKAL LKRFGLFGPP 600
    GIILFGADGR ERPVRVIGYQ SAGRFLDSLE RAFGTRPST 639
    Length:639
    Mass (Da):67,140
    Last modified:September 13, 2005 - v1
    Checksum:i6F99003AB556A031
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ62511.1.
    RefSeqiYP_297355.1. NC_007347.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ62511; AAZ62511; Reut_A3151.
    GeneIDi3610991.
    KEGGireu:Reut_A3151.
    PATRICi20232016. VBIRalEut24049_3834.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000090 Genomic DNA. Translation: AAZ62511.1 .
    RefSeqi YP_297355.1. NC_007347.1.

    3D structure databases

    ProteinModelPortali Q46WH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_A3151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ62511 ; AAZ62511 ; Reut_A3151 .
    GeneIDi 3610991.
    KEGGi reu:Reut_A3151.
    PATRICi 20232016. VBIRalEut24049_3834.

    Phylogenomic databases

    eggNOGi COG4232.
    HOGENOMi HOG000254982.
    KOi K04084.
    OMAi SCIEMEK.
    OrthoDBi EOG69D3B9.

    Enzyme and pathway databases

    BioCyci CPIN264198:GIW3-3205-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.1250. 1 hit.
    3.40.30.10. 1 hit.
    HAMAPi MF_00399. DbsD.
    InterProi IPR003834. Cyt_c_assmbl_TM_dom.
    IPR028250. DsbDN.
    IPR022910. Thiol_diS_interchange_DbsD.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    [Graphical view ]
    PANTHERi PTHR32234. PTHR32234. 1 hit.
    Pfami PF11412. DsbC. 1 hit.
    PF02683. DsbD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF74863. SSF74863. 1 hit.
    PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197Imported.

    Entry informationi

    Entry nameiQ46WH2_CUPPJ
    AccessioniPrimary (citable) accession number: Q46WH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3