Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thiol:disulfide interchange protein DsbD

Gene

dsbD

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.UniRule annotation

Catalytic activityi

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processCytochrome c-type biogenesisUniRule annotation, Electron transportUniRule annotation, Transport
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbDUniRule annotation (EC:1.8.1.8UniRule annotation)
Alternative name(s):
Protein-disulfide reductaseUniRule annotation
Short name:
Disulfide reductaseUniRule annotation
Gene namesi
Name:dsbDUniRule annotation
Ordered Locus Names:Reut_A3151Imported
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei212 – 233HelicalUniRule annotationAdd BLAST22
Transmembranei254 – 278HelicalUniRule annotationAdd BLAST25
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei331 – 364HelicalUniRule annotationAdd BLAST34
Transmembranei376 – 399HelicalUniRule annotationAdd BLAST24
Transmembranei411 – 428HelicalUniRule annotationAdd BLAST18
Transmembranei434 – 455HelicalUniRule annotationAdd BLAST22
Transmembranei467 – 487HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39UniRule annotationAdd BLAST39
ChainiPRO_500901918540 – 639Thiol:disulfide interchange protein DsbDUniRule annotationAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 149Redox-activeUniRule annotation
Disulfide bondi550 ↔ 553Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A3151.

Structurei

3D structure databases

ProteinModelPortaliQ46WH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini488 – 634ThioredoxinInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the thioredoxin family. DsbD subfamily.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CSG. Bacteria.
COG4232. LUCA.
HOGENOMiHOG000254982.
KOiK04084.
OMAiCVWPIIP.
OrthoDBiPOG091H0F5X.

Family and domain databases

Gene3Di2.60.40.1250. 1 hit.
HAMAPiMF_00399. DbsD. 1 hit.
InterProiView protein in InterPro
IPR003834. Cyt_c_assmbl_TM_dom.
IPR028250. DsbDN.
IPR022910. Thiol_diS_interchange_DbsD.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR32234:SF4. PTHR32234:SF4. 1 hit.
PfamiView protein in Pfam
PF11412. DsbC. 1 hit.
PF02683. DsbD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF74863. SSF74863. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46WH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGFALLAR SYGAGWARHI AAVLAVMVAW LCLVTGAHAA TEDDFLPPEQ
60 70 80 90 100
AFRFAARQID PQTIEVRFDV ASGYYLYRER FAFAARPDTV RLGQPEFPHG
110 120 130 140 150
KVKFDETFGK EMETYRDAVV IRLPVQSAPA DGKWSLVVTS QGCADKGLCY
160 170 180 190 200
PPMESVYKVG GSPLGNLFAD RPRSEATVPP AASARPGTEA VAPPARLDEN
210 220 230 240 250
DRIAGVLASR NLGVVLALFF GLGLLLTFTP CVLPMVPILS SIVVGEHATR
260 270 280 290 300
SRALVVSLAY VLGMAVVYTA IGVAAGLLGE GLAAALQTPA VLAAFAALMV
310 320 330 340 350
ALSLSMFGLY ELQLPQHWQT RLTATSNRRQ GGQVIGAAAM GAISALIVGP
360 370 380 390 400
CVTAPLAGAL AYIAQTRDAV TGGTALLAMA LGMGVPLVLV GVGAGNLLPR
410 420 430 440 450
AGHWMEATKR FFGFLLLGVA IWMVTPVLPA WLTMALWAAL LLVAAVFLGA
460 470 480 490 500
FDALGAEARG LARLGKGLGV LAALAGAILL LGLASGGRDP LQPLAHLSLA
510 520 530 540 550
RVAGGGAETA AGPQSVRFER VRSVAELDAR VAQAAAAGKP VLLDFYADWC
560 570 580 590 600
VSCKEMEHLT FTDAKVRARM SEIVLLQADV TANNADDKAL LKRFGLFGPP
610 620 630
GIILFGADGR ERPVRVIGYQ SAGRFLDSLE RAFGTRPST
Length:639
Mass (Da):67,140
Last modified:September 13, 2005 - v1
Checksum:i6F99003AB556A031
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ62511.1.
RefSeqiWP_011299294.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62511; AAZ62511; Reut_A3151.
KEGGireu:Reut_A3151.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ46WH2_CUPNJ
AccessioniPrimary (citable) accession number: Q46WH2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported