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Q46WH2

- Q46WH2_CUPPJ

UniProt

Q46WH2 - Q46WH2_CUPPJ

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Protein

Thiol:disulfide interchange protein DsbD

Gene
dsbD, Reut_A3151
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.UniRule annotation

Catalytic activityi

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.UniRule annotation

GO - Molecular functioni

  1. electron carrier activity Source: UniProtKB-HAMAP
  2. protein-disulfide reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell redox homeostasis Source: UniProtKB-HAMAP
  2. cytochrome complex assembly Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Cytochrome c-type biogenesisUniRule annotation, Electron transportUniRule annotation, Transport

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-3205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbDUniRule annotation (EC:1.8.1.8UniRule annotation)
Alternative name(s):
Protein-disulfide reductase
Gene namesi
Name:dsbDUniRule annotation
Ordered Locus Names:Reut_A3151Imported
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))Imported
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei212 – 23221Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei258 – 27821Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei290 – 31021Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei334 – 35421Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei375 – 39521Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei410 – 43021Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei431 – 45121Helical; By similarityUniRule annotationAdd
BLAST
Transmembranei467 – 48721Helical; By similarityUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 By similarityUniRule annotationAdd
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 149Redox-active By similarityUniRule annotation
Disulfide bondi231 ↔ 351Redox-active By similarityUniRule annotation
Disulfide bondi550 ↔ 553Redox-active By similarityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_A3151.

Structurei

3D structure databases

ProteinModelPortaliQ46WH2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini488 – 634147Thioredoxin By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family. DsbD subfamily.UniRule annotation
Contains 1 thioredoxin domain.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG4232.
HOGENOMiHOG000254982.
KOiK04084.
OMAiSCIEMEK.
OrthoDBiEOG69D3B9.

Family and domain databases

Gene3Di2.60.40.1250. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_00399. DbsD.
InterProiIPR003834. Cyt_c_assmbl_TM_dom.
IPR028250. DsbDN.
IPR022910. Thiol_diS_interchange_DbsD.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PANTHERiPTHR32234. PTHR32234. 1 hit.
PfamiPF11412. DsbC. 1 hit.
PF02683. DsbD. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF74863. SSF74863. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46WH2-1 [UniParc]FASTAAdd to Basket

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MSMGFALLAR SYGAGWARHI AAVLAVMVAW LCLVTGAHAA TEDDFLPPEQ    50
AFRFAARQID PQTIEVRFDV ASGYYLYRER FAFAARPDTV RLGQPEFPHG 100
KVKFDETFGK EMETYRDAVV IRLPVQSAPA DGKWSLVVTS QGCADKGLCY 150
PPMESVYKVG GSPLGNLFAD RPRSEATVPP AASARPGTEA VAPPARLDEN 200
DRIAGVLASR NLGVVLALFF GLGLLLTFTP CVLPMVPILS SIVVGEHATR 250
SRALVVSLAY VLGMAVVYTA IGVAAGLLGE GLAAALQTPA VLAAFAALMV 300
ALSLSMFGLY ELQLPQHWQT RLTATSNRRQ GGQVIGAAAM GAISALIVGP 350
CVTAPLAGAL AYIAQTRDAV TGGTALLAMA LGMGVPLVLV GVGAGNLLPR 400
AGHWMEATKR FFGFLLLGVA IWMVTPVLPA WLTMALWAAL LLVAAVFLGA 450
FDALGAEARG LARLGKGLGV LAALAGAILL LGLASGGRDP LQPLAHLSLA 500
RVAGGGAETA AGPQSVRFER VRSVAELDAR VAQAAAAGKP VLLDFYADWC 550
VSCKEMEHLT FTDAKVRARM SEIVLLQADV TANNADDKAL LKRFGLFGPP 600
GIILFGADGR ERPVRVIGYQ SAGRFLDSLE RAFGTRPST 639
Length:639
Mass (Da):67,140
Last modified:September 13, 2005 - v1
Checksum:i6F99003AB556A031
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62511.1.
RefSeqiYP_297355.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62511; AAZ62511; Reut_A3151.
GeneIDi3610991.
KEGGireu:Reut_A3151.
PATRICi20232016. VBIRalEut24049_3834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62511.1 .
RefSeqi YP_297355.1. NC_007347.1.

3D structure databases

ProteinModelPortali Q46WH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A3151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ62511 ; AAZ62511 ; Reut_A3151 .
GeneIDi 3610991.
KEGGi reu:Reut_A3151.
PATRICi 20232016. VBIRalEut24049_3834.

Phylogenomic databases

eggNOGi COG4232.
HOGENOMi HOG000254982.
KOi K04084.
OMAi SCIEMEK.
OrthoDBi EOG69D3B9.

Enzyme and pathway databases

BioCyci CPIN264198:GIW3-3205-MONOMER.

Family and domain databases

Gene3Di 2.60.40.1250. 1 hit.
3.40.30.10. 1 hit.
HAMAPi MF_00399. DbsD.
InterProi IPR003834. Cyt_c_assmbl_TM_dom.
IPR028250. DsbDN.
IPR022910. Thiol_diS_interchange_DbsD.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view ]
PANTHERi PTHR32234. PTHR32234. 1 hit.
Pfami PF11412. DsbC. 1 hit.
PF02683. DsbD. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF74863. SSF74863. 1 hit.
PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiQ46WH2_CUPPJ
AccessioniPrimary (citable) accession number: Q46WH2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi