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Q46VZ5

- GCSP_CUPPJ

UniProt

Q46VZ5 - GCSP_CUPPJ

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Reut_A3331
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-3396-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Reut_A3331
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 976976Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei722 – 7221N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi264198.Reut_A3331.

Structurei

3D structure databases

ProteinModelPortaliQ46VZ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46VZ5-1 [UniParc]FASTAAdd to Basket

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MNAPLPMTAT QGNRPTLAEL EARDAFAARH IGPDTPEQQH MLKVLGYDSR    50
AALIDAVIPE AIRRRDGMPM GEFTEPLPEE AALAKLRKLA GKNKVLKSFI 100
GQGYYNTLTP AVVLRNIFEN PAWYTAYTPY QPEISQGRLE AMLNFQQMVT 150
DLTGLDIANA SMLDEGTAAA EAMTLLQRVN KHASNTFYVA DDVLPQTLEV 200
VRTRAKPLGI EVKVGPAADA AAAHAFGVLL QYPGVNGDVT DYRAIADAVH 250
AAGGLVVAAA DLLALTLITA PGEWGADVAV GNSQRFGVPL GFGGPHAGYM 300
AVKDAFKRSM PGRLVGVTVD AQGNKAYRLA LQTREQHIRR EKATSNICTA 350
QVLLAVMASM YAVYHGPQGL KRIAQRVHRL TATLAAGLQT LGFTRTNATF 400
FDTLTFETGF NTDAIHAAAT ARGINLRHAG ATRIGVSLDE TATRDDVVAL 450
WEIFSHGKPL PASLTFDAIE AAAEDAFPAN LARTSAYLTH PVFNTHHAEH 500
EMLRYLRMLA DKDLALDRTM IPLGSCTMKL NATSEMIPVT WPEFSQIHPF 550
APLDQTVGYR EMIDQLEAML CAATGYAAVS LQPNAGSQGE YAGLLIIHAY 600
HASRGESHRD ICLIPSSAHG TNPASAQMAG MKVVVVACDE NGNVDLEDLA 650
KKAELHSKNL AAIMITYPST HGVFEQGVQQ ICEIVHQHGG QVYVDGANMN 700
AMVGTAAPGH FGGDVSHLNL HKTFCIPHGG GGPGVGPVAV GAHLADFLPN 750
QDSVGYRRDD NGIGGVSAAP FGSASILPIS WMYIAMMGSA GLTAATENAI 800
LTANYVAKRL SPHYPVLYTG QHGLVAHECI LDLRPLQKET GISNEDVAKR 850
LMDYGFHAPT MSFPVPGTLM IEPTESEALH ELDRFIDAMI AIRKEIGRVE 900
DGSFDRDDNP LKHAPHTAAV VTANEWTRKY TREEAAYPVA SLRTQKYWPP 950
VGRADNVYGD RNLFCSCVPM SEYAQD 976
Length:976
Mass (Da):105,208
Last modified:September 13, 2005 - v1
Checksum:i37C1F8DEB02584C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62689.1.
RefSeqiWP_011299458.1. NC_007347.1.
YP_297533.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62689; AAZ62689; Reut_A3331.
GeneIDi3609710.
KEGGireu:Reut_A3331.
PATRICi20232406. VBIRalEut24049_4017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000090 Genomic DNA. Translation: AAZ62689.1 .
RefSeqi WP_011299458.1. NC_007347.1.
YP_297533.1. NC_007347.1.

3D structure databases

ProteinModelPortali Q46VZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A3331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ62689 ; AAZ62689 ; Reut_A3331 .
GeneIDi 3609710.
KEGGi reu:Reut_A3331.
PATRICi 20232406. VBIRalEut24049_4017.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPIN264198:GIW3-3396-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiGCSP_CUPPJ
AccessioniPrimary (citable) accession number: Q46VZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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