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Q46VZ5 (GCSP_CUPPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Reut_A3331
OrganismCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)) [Complete proteome] [HAMAP]
Taxonomic identifier264198 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length976 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 976976Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227123

Amino acid modifications

Modified residue7221N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q46VZ5 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 37C1F8DEB02584C3

FASTA976105,208
        10         20         30         40         50         60 
MNAPLPMTAT QGNRPTLAEL EARDAFAARH IGPDTPEQQH MLKVLGYDSR AALIDAVIPE 

        70         80         90        100        110        120 
AIRRRDGMPM GEFTEPLPEE AALAKLRKLA GKNKVLKSFI GQGYYNTLTP AVVLRNIFEN 

       130        140        150        160        170        180 
PAWYTAYTPY QPEISQGRLE AMLNFQQMVT DLTGLDIANA SMLDEGTAAA EAMTLLQRVN 

       190        200        210        220        230        240 
KHASNTFYVA DDVLPQTLEV VRTRAKPLGI EVKVGPAADA AAAHAFGVLL QYPGVNGDVT 

       250        260        270        280        290        300 
DYRAIADAVH AAGGLVVAAA DLLALTLITA PGEWGADVAV GNSQRFGVPL GFGGPHAGYM 

       310        320        330        340        350        360 
AVKDAFKRSM PGRLVGVTVD AQGNKAYRLA LQTREQHIRR EKATSNICTA QVLLAVMASM 

       370        380        390        400        410        420 
YAVYHGPQGL KRIAQRVHRL TATLAAGLQT LGFTRTNATF FDTLTFETGF NTDAIHAAAT 

       430        440        450        460        470        480 
ARGINLRHAG ATRIGVSLDE TATRDDVVAL WEIFSHGKPL PASLTFDAIE AAAEDAFPAN 

       490        500        510        520        530        540 
LARTSAYLTH PVFNTHHAEH EMLRYLRMLA DKDLALDRTM IPLGSCTMKL NATSEMIPVT 

       550        560        570        580        590        600 
WPEFSQIHPF APLDQTVGYR EMIDQLEAML CAATGYAAVS LQPNAGSQGE YAGLLIIHAY 

       610        620        630        640        650        660 
HASRGESHRD ICLIPSSAHG TNPASAQMAG MKVVVVACDE NGNVDLEDLA KKAELHSKNL 

       670        680        690        700        710        720 
AAIMITYPST HGVFEQGVQQ ICEIVHQHGG QVYVDGANMN AMVGTAAPGH FGGDVSHLNL 

       730        740        750        760        770        780 
HKTFCIPHGG GGPGVGPVAV GAHLADFLPN QDSVGYRRDD NGIGGVSAAP FGSASILPIS 

       790        800        810        820        830        840 
WMYIAMMGSA GLTAATENAI LTANYVAKRL SPHYPVLYTG QHGLVAHECI LDLRPLQKET 

       850        860        870        880        890        900 
GISNEDVAKR LMDYGFHAPT MSFPVPGTLM IEPTESEALH ELDRFIDAMI AIRKEIGRVE 

       910        920        930        940        950        960 
DGSFDRDDNP LKHAPHTAAV VTANEWTRKY TREEAAYPVA SLRTQKYWPP VGRADNVYGD 

       970 
RNLFCSCVPM SEYAQD 

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References

[1]"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JMP134 / LMG 1197.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000090 Genomic DNA. Translation: AAZ62689.1.
RefSeqYP_297533.1. NC_007347.1.

3D structure databases

ProteinModelPortalQ46VZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264198.Reut_A3331.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ62689; AAZ62689; Reut_A3331.
GeneID3609710.
KEGGreu:Reut_A3331.
PATRIC20232406. VBIRalEut24049_4017.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycCPIN264198:GIW3-3396-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_CUPPJ
AccessionPrimary (citable) accession number: Q46VZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families