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Q46VZ5

- GCSP_CUPPJ

UniProt

Q46VZ5 - GCSP_CUPPJ

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-3396-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Reut_A3331
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 976976Glycine dehydrogenase (decarboxylating)PRO_0000227123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei722 – 7221N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_A3331.

Structurei

3D structure databases

ProteinModelPortaliQ46VZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46VZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPLPMTAT QGNRPTLAEL EARDAFAARH IGPDTPEQQH MLKVLGYDSR
60 70 80 90 100
AALIDAVIPE AIRRRDGMPM GEFTEPLPEE AALAKLRKLA GKNKVLKSFI
110 120 130 140 150
GQGYYNTLTP AVVLRNIFEN PAWYTAYTPY QPEISQGRLE AMLNFQQMVT
160 170 180 190 200
DLTGLDIANA SMLDEGTAAA EAMTLLQRVN KHASNTFYVA DDVLPQTLEV
210 220 230 240 250
VRTRAKPLGI EVKVGPAADA AAAHAFGVLL QYPGVNGDVT DYRAIADAVH
260 270 280 290 300
AAGGLVVAAA DLLALTLITA PGEWGADVAV GNSQRFGVPL GFGGPHAGYM
310 320 330 340 350
AVKDAFKRSM PGRLVGVTVD AQGNKAYRLA LQTREQHIRR EKATSNICTA
360 370 380 390 400
QVLLAVMASM YAVYHGPQGL KRIAQRVHRL TATLAAGLQT LGFTRTNATF
410 420 430 440 450
FDTLTFETGF NTDAIHAAAT ARGINLRHAG ATRIGVSLDE TATRDDVVAL
460 470 480 490 500
WEIFSHGKPL PASLTFDAIE AAAEDAFPAN LARTSAYLTH PVFNTHHAEH
510 520 530 540 550
EMLRYLRMLA DKDLALDRTM IPLGSCTMKL NATSEMIPVT WPEFSQIHPF
560 570 580 590 600
APLDQTVGYR EMIDQLEAML CAATGYAAVS LQPNAGSQGE YAGLLIIHAY
610 620 630 640 650
HASRGESHRD ICLIPSSAHG TNPASAQMAG MKVVVVACDE NGNVDLEDLA
660 670 680 690 700
KKAELHSKNL AAIMITYPST HGVFEQGVQQ ICEIVHQHGG QVYVDGANMN
710 720 730 740 750
AMVGTAAPGH FGGDVSHLNL HKTFCIPHGG GGPGVGPVAV GAHLADFLPN
760 770 780 790 800
QDSVGYRRDD NGIGGVSAAP FGSASILPIS WMYIAMMGSA GLTAATENAI
810 820 830 840 850
LTANYVAKRL SPHYPVLYTG QHGLVAHECI LDLRPLQKET GISNEDVAKR
860 870 880 890 900
LMDYGFHAPT MSFPVPGTLM IEPTESEALH ELDRFIDAMI AIRKEIGRVE
910 920 930 940 950
DGSFDRDDNP LKHAPHTAAV VTANEWTRKY TREEAAYPVA SLRTQKYWPP
960 970
VGRADNVYGD RNLFCSCVPM SEYAQD
Length:976
Mass (Da):105,208
Last modified:September 13, 2005 - v1
Checksum:i37C1F8DEB02584C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ62689.1.
RefSeqiYP_297533.1. NC_007347.1.

Genome annotation databases

EnsemblBacteriaiAAZ62689; AAZ62689; Reut_A3331.
GeneIDi3609710.
KEGGireu:Reut_A3331.
PATRICi20232406. VBIRalEut24049_4017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000090 Genomic DNA. Translation: AAZ62689.1 .
RefSeqi YP_297533.1. NC_007347.1.

3D structure databases

ProteinModelPortali Q46VZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_A3331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ62689 ; AAZ62689 ; Reut_A3331 .
GeneIDi 3609710.
KEGGi reu:Reut_A3331.
PATRICi 20232406. VBIRalEut24049_4017.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPIN264198:GIW3-3396-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiGCSP_CUPPJ
AccessioniPrimary (citable) accession number: Q46VZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3