Q46VT8 (PHS2_CUPPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative pterin-4-alpha-carbinolamine dehydratase 2
Short name=PHS 2
EC=4.2.1.96

Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase 2
Pterin carbinolamine dehydratase 2
Short name=PCD 2

Gene names

Ordered Locus Names:

Reut_A3388

Organism

Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. HAMAP MF_00434
Sequence similarities	Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Sequence caution	The sequence AAZ62746.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 100	100	Putative pterin-4-alpha-carbinolamine dehydratase 2 HAMAP MF_00434		PRO_0000231470

Sequences

	Sequence		Length	Mass (Da)
	Q46VT8 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 5E750A0AC9613CFC	FASTA	100	11,368
	10 20 30 40 50 60 MTPLSPQARA TLLAELPGWT DVDNRDAIQK RFTFPDFNAA FAFMTRVAIQ AEKADHHPEW 70 80 90 100 FNVYNRVDIT LSTHDANGLT QRDIDLAHFI ERAAASLRVE

References

[1]

"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JMP134 / LMG 1197.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000090 Genomic DNA. Translation: AAZ62746.1. Different initiation.
RefSeq	YP_297590.1. NC_007347.1.
3D structure databases
ProteinModelPortal	Q46VT8.
SMR	Q46VT8. Positions 4-97.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46VT8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3610576.
GenomeReviews	Gene locus Reut_A3388 in contig CP000090_GR.
KEGG	reu:Reut_A3388.
NMPDR	fig|264198.3.peg.3875.
PATRIC	20232524. VBIRalEut24049_4076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG705804.
ProtClustDB	PRK00823.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_A3388-MONOMER.
Family and domain databases
HAMAP	MF_00434. Pterin_4_alpha. [Tree]
InterPro	IPR001533. Trans/pterin_deHydtase. [Graphical view]
Gene3D	G3DSA:3.30.1360.20. Trans_pterinDh. 1 hit.
KO	K01724.
PANTHER	PTHR12599. Trans_pterinDh. 1 hit.
Pfam	PF01329. Pterin_4a. 1 hit. [Graphical view]
SUPFAM	SSF55248. Trans_pterinDh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHS2_CUPPJ

Accession

Primary (citable) accession number: Q46VT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program