Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chemotaxis response regulator protein-glutamate methylesterase 1

Gene

cheB1

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158UniRule annotation1
Active sitei185UniRule annotation1
Active sitei278UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 1UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Ordered Locus Names:Reut_B3648
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254791 – 341Chemotaxis response regulator protein-glutamate methylesterase 1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_B3648.

Structurei

3D structure databases

ProteinModelPortaliQ46V28.
SMRiQ46V28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini146 – 336CheB-type methylesteraseUniRule annotationAdd BLAST191

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK13491.
OMAiAMVKIRQ.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46V28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVGIVNDSA LAVAALRRAI ALDPAFEIVW VAGDGEQAVQ LAASHTPDVI
60 70 80 90 100
LMDLLMPVMD GVEATRRIMA ATPCPIVVVT TDLGRNATQV FDAMGHGAID
110 120 130 140 150
AVDTPTLTES DAKLTAGPLL RKMRNIGRLV AGRAAPRPAI TEMPGTLAAS
160 170 180 190 200
RLVAIGASAG GPAALAKLLG ALPADFCAAV VAVQHVDEAF APGMADWLDS
210 220 230 240 250
QCALPVRVAA PGETPQAGTV LIAGTNNHLR LLGSNRMAYT EQPSEYLYRP
260 270 280 290 300
SIDVFFESVV EYWRGQAIGV LLTGMGRDGA SGLKAMRDHG CLTIAQDQAT
310 320 330 340
SAVYGMPKAA AAMGAASEIL PLTAIAPRLV QACCSVRPPP G
Length:341
Mass (Da):35,278
Last modified:September 13, 2005 - v1
Checksum:i1A1C222071EFA7B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000091 Genomic DNA. Translation: AAZ63006.1.
RefSeqiWP_011299773.1. NC_007348.1.

Genome annotation databases

EnsemblBacteriaiAAZ63006; AAZ63006; Reut_B3648.
KEGGireu:Reut_B3648.

Similar proteinsi

Entry informationi

Entry nameiCHEB1_CUPNJ
AccessioniPrimary (citable) accession number: Q46V28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome