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Q46UT0

- RBKTP_CUPPJ

UniProt

Q46UT0 - RBKTP_CUPPJ

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Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene
phnN, Reut_B3746
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity.UniRule annotation

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorylase activity Source: InterPro
  3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
  4. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. organic phosphonate transport Source: UniProtKB-KW
  3. pyrimidine nucleobase metabolic process Source: InterPro
  4. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Alkylphosphonate uptake

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-3820-MONOMER.
UniPathwayiUPA00087; UER00175.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Including the following 2 domains:
Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
Alternative name(s):
Ribose 1,5-bisphosphokinase
Putative thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:phnN
Ordered Locus Names:Reut_B3746
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylaseUniRule annotationPRO_0000314710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_B3746.

Structurei

3D structure databases

ProteinModelPortaliQ46UT0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 187187Ribose 1,5-bisphosphokinaseUniRule annotationAdd
BLAST
Regioni188 – 602415ThymidinephosphorylaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiCLIWGGH.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46UT0-1 [UniParc]FASTAAdd to Basket

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MKESGTFFLV VGPSGAGKDS LIDGARATLG NDEYVFARRI ITRPSGSPGE    50
DHESVAEAEF AERERNGEFL VTWHAHGLRY GLPQWLVGLL ETGKHVVANG 100
SRGVIAMLAR QLPRFVVVNV TAPQDVLAQR IAARGRESGD DVMRRVARQA 150
PPMPDGVHCV TVTNDSTLDL GVARFTDALR NGANAGSVPQ PASRRHLAAK 200
LDGQPLDEGA YEAILRDAIA GRYTAQELTA FLTAATRSLD DREVVALARA 250
RTRFTARIEW DEPIVVDKHS MGGIPGSRIT LIVVPIVAAY GLAMPKTSSR 300
AITSAAGTAD AMETVARVDL THDDVRRCVA QARACIAWNG RLNHSVIDDV 350
MNAITRPLGL DSRRWAVASI LSKKATAGAT HVIVDIPYGP QTKLSARADA 400
DALAGLFEEV GKGLGLHVRA LVTDGSRPIG RGVGPALEVR DVRQVLENHP 450
DAPMDLREKA LRFAGEIIAF DPRVASAAQG MRIATALLDE GSARAAFDRI 500
VATQGIRPDP VAPGAHTHVI VAPAEGRVAA INGWQISGIA RAAGAPRSAG 550
AGIDLLCTIG ERVAAGEPLY RIHAESAADL ATAVAMTGPA GEASTAVRVD 600
PD 602
Length:602
Mass (Da):63,580
Last modified:January 15, 2008 - v2
Checksum:iD622AFD8F873E7CA
GO

Sequence cautioni

The sequence AAZ63104.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000091 Genomic DNA. Translation: AAZ63104.1. Different initiation.
RefSeqiYP_297948.1. NC_007348.1.

Genome annotation databases

EnsemblBacteriaiAAZ63104; AAZ63104; Reut_B3746.
GeneIDi3613838.
KEGGireu:Reut_B3746.
PATRICi20233289. VBIRalEut24049_4448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000091 Genomic DNA. Translation: AAZ63104.1 . Different initiation.
RefSeqi YP_297948.1. NC_007348.1.

3D structure databases

ProteinModelPortali Q46UT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_B3746.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ63104 ; AAZ63104 ; Reut_B3746 .
GeneIDi 3613838.
KEGGi reu:Reut_B3746.
PATRICi 20233289. VBIRalEut24049_4448.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi CLIWGGH.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00087 ; UER00175 .
BioCyci CPIN264198:GIW3-3820-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 2 hits.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02322. phosphon_PhnN. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry nameiRBKTP_CUPPJ
AccessioniPrimary (citable) accession number: Q46UT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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