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Q46UT0

- RBKTP_CUPPJ

UniProt

Q46UT0 - RBKTP_CUPPJ

Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

    Catalytic activityi

    ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorylase activity Source: InterPro
    3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
    4. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. organic phosphonate transport Source: UniProtKB-KW
    3. pyrimidine nucleobase metabolic process Source: InterPro
    4. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Alkylphosphonate uptake

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-3820-MONOMER.
    UniPathwayiUPA00087; UER00175.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
    Including the following 2 domains:
    Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
    Alternative name(s):
    Ribose 1,5-bisphosphokinase
    Putative thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:phnN
    Ordered Locus Names:Reut_B3746
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000314710Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264198.Reut_B3746.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46UT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 187187Ribose 1,5-bisphosphokinaseAdd
    BLAST
    Regioni188 – 602415ThymidinephosphorylaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
    In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiCLIWGGH.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 2 hits.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46UT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKESGTFFLV VGPSGAGKDS LIDGARATLG NDEYVFARRI ITRPSGSPGE    50
    DHESVAEAEF AERERNGEFL VTWHAHGLRY GLPQWLVGLL ETGKHVVANG 100
    SRGVIAMLAR QLPRFVVVNV TAPQDVLAQR IAARGRESGD DVMRRVARQA 150
    PPMPDGVHCV TVTNDSTLDL GVARFTDALR NGANAGSVPQ PASRRHLAAK 200
    LDGQPLDEGA YEAILRDAIA GRYTAQELTA FLTAATRSLD DREVVALARA 250
    RTRFTARIEW DEPIVVDKHS MGGIPGSRIT LIVVPIVAAY GLAMPKTSSR 300
    AITSAAGTAD AMETVARVDL THDDVRRCVA QARACIAWNG RLNHSVIDDV 350
    MNAITRPLGL DSRRWAVASI LSKKATAGAT HVIVDIPYGP QTKLSARADA 400
    DALAGLFEEV GKGLGLHVRA LVTDGSRPIG RGVGPALEVR DVRQVLENHP 450
    DAPMDLREKA LRFAGEIIAF DPRVASAAQG MRIATALLDE GSARAAFDRI 500
    VATQGIRPDP VAPGAHTHVI VAPAEGRVAA INGWQISGIA RAAGAPRSAG 550
    AGIDLLCTIG ERVAAGEPLY RIHAESAADL ATAVAMTGPA GEASTAVRVD 600
    PD 602
    Length:602
    Mass (Da):63,580
    Last modified:January 15, 2008 - v2
    Checksum:iD622AFD8F873E7CA
    GO

    Sequence cautioni

    The sequence AAZ63104.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000091 Genomic DNA. Translation: AAZ63104.1. Different initiation.
    RefSeqiYP_297948.1. NC_007348.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ63104; AAZ63104; Reut_B3746.
    GeneIDi3613838.
    KEGGireu:Reut_B3746.
    PATRICi20233289. VBIRalEut24049_4448.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000091 Genomic DNA. Translation: AAZ63104.1 . Different initiation.
    RefSeqi YP_297948.1. NC_007348.1.

    3D structure databases

    ProteinModelPortali Q46UT0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_B3746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ63104 ; AAZ63104 ; Reut_B3746 .
    GeneIDi 3613838.
    KEGGi reu:Reut_B3746.
    PATRICi 20233289. VBIRalEut24049_4448.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi CLIWGGH.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00175 .
    BioCyci CPIN264198:GIW3-3820-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 2 hits.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197.

    Entry informationi

    Entry nameiRBKTP_CUPPJ
    AccessioniPrimary (citable) accession number: Q46UT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3