ID   HGD_RALEJ               Reviewed;         439 AA.
AC   Q46UA4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   04-NOV-2008, entry version 24.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=Reut_B3923;
OS   Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M.,
RA   Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000091; AAZ63280.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_298124.1; -.
DR   GeneID; 3614130; -.
DR   GenomeReviews; CP000091_GR; Reut_B3923.
DR   KEGG; reu:Reut_B3923; -.
DR   NMPDR; fig|264198.3.peg.4480; -.
DR   HOGENOM; Q46UA4; -.
DR   BioCyc; REUT264198:REUT_B3923-MON; -.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    439       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_0000225794.
FT   METAL       336    336       Iron (By similarity).
FT   METAL       342    342       Iron (By similarity).
FT   METAL       372    372       Iron (By similarity).
SQ   SEQUENCE   439 AA;  48732 MW;  293FAF36EFC3752D CRC64;
     MNLTHTQLAE HGYMSGFANE FATEALPGAL PVGQNSPQRA PYGLYAEQLS GTAFTAPRAH
     NRRSWLYRIR PGAVHKPFTL VEQSRFLSRF DEVPPSPNQM RWSPPAMPTT PTDFIDGIVT
     MAGNGGPDAM TGCGIHLYLA NQSMQDRFFY NADGEMLIVP QQGRVRFVTE MGRLDVEPQE
     IVVIPRGVRF RVELPDGEAR GYICENYGAL FKLPDLGVIG SNGLANPRDF MTPVAAYEDR
     EGDFELVAKF QGNLWRADIG HSPLDVVAWH GNFAPYKYDL RRFNTIGSIS FDHPDPSIFL
     VLQSPSDTPG VDTIDFVIFG PRWLAMENSF RPPWFHRNIA SEFMGLITGV YDAKADGFAP
     GGASLHNCMS GHGPDADTFA KATSADTSTP HHITDTMAFM FETPGVIRPT PYAARSASLQ
     QDYYTCWQGL KKHFNPNVR
//