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Q46UA4 (HGD_CUPPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:Reut_B3923
OrganismCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)) [Complete proteome] [HAMAP]
Taxonomic identifier264198 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence caution

The sequence AAZ63280.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000225794

Sites

Metal binding3361Iron By similarity
Metal binding3421Iron By similarity
Metal binding3721Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q46UA4 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 293FAF36EFC3752D

FASTA43948,732
        10         20         30         40         50         60 
MNLTHTQLAE HGYMSGFANE FATEALPGAL PVGQNSPQRA PYGLYAEQLS GTAFTAPRAH 

        70         80         90        100        110        120 
NRRSWLYRIR PGAVHKPFTL VEQSRFLSRF DEVPPSPNQM RWSPPAMPTT PTDFIDGIVT 

       130        140        150        160        170        180 
MAGNGGPDAM TGCGIHLYLA NQSMQDRFFY NADGEMLIVP QQGRVRFVTE MGRLDVEPQE 

       190        200        210        220        230        240 
IVVIPRGVRF RVELPDGEAR GYICENYGAL FKLPDLGVIG SNGLANPRDF MTPVAAYEDR 

       250        260        270        280        290        300 
EGDFELVAKF QGNLWRADIG HSPLDVVAWH GNFAPYKYDL RRFNTIGSIS FDHPDPSIFL 

       310        320        330        340        350        360 
VLQSPSDTPG VDTIDFVIFG PRWLAMENSF RPPWFHRNIA SEFMGLITGV YDAKADGFAP 

       370        380        390        400        410        420 
GGASLHNCMS GHGPDADTFA KATSADTSTP HHITDTMAFM FETPGVIRPT PYAARSASLQ 

       430 
QDYYTCWQGL KKHFNPNVR 

« Hide

References

[1]"Complete sequence of chromosome 2 of Ralstonia eutropha JMP134."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JMP134 / LMG 1197.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000091 Genomic DNA. Translation: AAZ63280.1. Different initiation.
RefSeqYP_298124.1. NC_007348.1.

3D structure databases

ProteinModelPortalQ46UA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264198.Reut_B3923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ63280; AAZ63280; Reut_B3923.
GeneID3614130.
KEGGreu:Reut_B3923.
PATRIC20233659. VBIRalEut24049_4633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycCPIN264198:GIW3-3997-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_CUPPJ
AccessionPrimary (citable) accession number: Q46UA4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways