ID   Q46U78_CUPPJ            Unreviewed;       587 AA.
AC   Q46U78;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Dihydroxyacid dehydratase {ECO:0000313|EMBL:AAZ63306.1};
DE            EC=4.2.1.9 {ECO:0000313|EMBL:AAZ63306.1};
GN   OrderedLocusNames=Reut_B3950 {ECO:0000313|EMBL:AAZ63306.1};
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS   (strain JMP 134)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198 {ECO:0000313|EMBL:AAZ63306.1};
RN   [1] {ECO:0000313|EMBL:AAZ63306.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 {ECO:0000313|EMBL:AAZ63306.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J.,
RA   Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486}.
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DR   EMBL; CP000091; AAZ63306.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46U78; -.
DR   STRING; 264198.Reut_B3950; -.
DR   KEGG; reu:Reut_B3950; -.
DR   eggNOG; COG0129; Bacteria.
DR   HOGENOM; CLU_014271_3_0_4; -.
DR   OrthoDB; 9807077at2; -.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   PANTHER; PTHR43183:SF1; HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED; 1.
DR   PANTHER; PTHR43183; HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:AAZ63306.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
SQ   SEQUENCE   587 AA;  61737 MW;  3D3AE12CB36E31EB CRC64;
     MPYADDPKLP QDGAAPTEGL AKGLTNYGDT GFSLFLRKAF IKGAGFTDDA LSRPVIGIVN
     TGSSYNPCHG NAPQLVEAVK RGVMLAGGLP VDFPTISVHE SFSAPTSMYL RNLMSMDTEE
     MIRAQPMDAV VLIGGCDKTV PAQLMGAASA GVPAIQLVTG SMLTGSHRSE RVGACTDCRR
     YWGRYRAEEI DSAEIADVNN QLVASVGTCS VMGTASTMAC VAEALGMMVS GGASAPAVTA
     DRVRVAERTG TTAVGMAAAR LTPDRILTGK AFENALRVLL AIGGSTNGIV HLTAIAGRLG
     IDIDLAGLDR MSRETPVLVD LKPSGQHYME DFHKAGGMLT LLRELRPLLH LDTLTVSGRT
     LGEELDAAPP LFPQDVIRSA GNPIYPAGGL AVLRGNLAPG GAIIKQSAAN PALMEHEGRA
     VVFENAEDMA QRIDDESLDV KADDILVLKR IGPTGAPGMP EAGYMPIPKK LARAGVKDMV
     RVSDGRMSGT AAGTIVLHVT PEAAIGGPLA LVQSGDRIRL SVANREIALL VDDAELARRA
     AAQPVERPRA ERGYRKLFLE TVTQADQGVD FDFLRAAQTV DTVPKQG
//