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UniProtKB - Q46TF2 (GLGB_CUPNJ)

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Protein

1,4-alpha-glucan branching enzyme GlgB

Gene

glgB

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.UniRule annotation

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei425NucleophileUniRule annotation1
Active sitei478Proton donorUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

Enzyme and pathway databases

UniPathwayiUPA00164.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan branching enzyme GlgBUniRule annotation (EC:2.4.1.18UniRule annotation)
Alternative name(s):
1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferaseUniRule annotation
Alpha-(1->4)-glucan branching enzymeUniRule annotation
Glycogen branching enzymeUniRule annotation
Short name:
BEUniRule annotation
Gene namesi
Name:glgBUniRule annotation
Ordered Locus Names:Reut_B4229
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus ›
Proteomesi
  • UP000002697 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002606811 – 7501,4-alpha-glucan branching enzyme GlgBAdd BLAST750

Proteomic databases

PRIDEiQ46TF2.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_B4229.

Structurei

3D structure databases

ProteinModelPortaliQ46TF2.
SMRiQ46TF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9C. Bacteria.
COG0296. LUCA.
HOGENOMiHOG000283037.
KOiK00700.
OMAiEVVHGKS.
OrthoDBiPOG091H08D1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
HAMAPiMF_00685. GlgB. 1 hit.
InterProiView protein in InterPro
IPR006048. A-amylase/branching_C.
IPR006407. GlgB.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
PIRSFiPIRSF000463. GlgB. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46TF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRVDTRPPE RRTQTISDGE LGALVEGRHR DPFAILGPHR DGDTLIVRAC 
        60         70         80         90        100
VPGAHSVMLA DSRGEPLAPM TPLHAGGVFT GRLPAGVSVY QLLVRWHNGT 
       110        120        130        140        150
QQVSHDPYAF GLLLGELDLH LIAEGRHFEL GACLGAQWRN VDGVQGVRFA 
       160        170        180        190        200
VWAPNARRVS VIGDFNGWQP ARHPMRLRHP SGVWELFIPE AMGARPGCRY 
       210        220        230        240        250
KFDLLDPHDA QLPDKADPLA LATEAPPATA SVVTQPQVSA PPFAWQDDEW 
       260        270        280        290        300
MRLRNAVDPY AAPLSIYEVH VGSWLRAAND PARGWEVLAD RLIPYVHELG 
       310        320        330        340        350
FTHIELLPVT EHPFGGSWGY QPLSLYAPTA RLGPPQAFAA FIDRCHRDGI 
       360        370        380        390        400
GVILDWVPAH FPTDPHGLAR FDGTALYEHE DPREGFHQDW NTLIYNLGRN 
       410        420        430        440        450
EVRGFLLAGA LHWLEHFHVD GLRVDAVASM LYRDYSRAPD QWVPNRFGGR 
       460        470        480        490        500
ENLEAVAFLR ELNTVVHERC PGALTIAEES TAWPGVTASA ASGGLGFDFK 
       510        520        530        540        550
WNMGWMHDTL RYLSLDPIHR AWHHQDMTFG TVYAWSEAFV LPLSHDEVVH 
       560        570        580        590        600
GKGSMLRKCP GDDWQRFAGL RAYYGFMWAH PGKKLLFMGG ELAQWQEWNH 
       610        620        630        640        650
DAELDWALLD HPMHRGVHTL VRDLNALYRE LPALHELDHS PAGFQWVVGD 
       660        670        680        690        700
DHQNSVFAWL RRPAPGSGDV VLAVTNMTPV PRYGYRIGVP SEGCWHERLN 
       710        720        730        740        750
TDAACYGGSN LGNGGAVTAE PVPSHGQEAS VLLTLPPLAT VILQHAGTQA
Length:750
Mass (Da):83,328
Last modified:September 13, 2005 - v1
Checksum:i7A95B1AAF97F5954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000091 Genomic DNA. Translation: AAZ63582.1.
RefSeqiWP_011300348.1. NC_007348.1.

Genome annotation databases

EnsemblBacteriaiAAZ63582; AAZ63582; Reut_B4229.
KEGGireu:Reut_B4229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000091 Genomic DNA. Translation: AAZ63582.1.
RefSeqiWP_011300348.1. NC_007348.1.

3D structure databases

ProteinModelPortaliQ46TF2.
SMRiQ46TF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264198.Reut_B4229.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Proteomic databases

PRIDEiQ46TF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ63582; AAZ63582; Reut_B4229.
KEGGireu:Reut_B4229.

Phylogenomic databases

eggNOGiENOG4105C9C. Bacteria.
COG0296. LUCA.
HOGENOMiHOG000283037.
KOiK00700.
OMAiEVVHGKS.
OrthoDBiPOG091H08D1.

Enzyme and pathway databases

UniPathwayiUPA00164.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
HAMAPiMF_00685. GlgB. 1 hit.
InterProiView protein in InterPro
IPR006048. A-amylase/branching_C.
IPR006407. GlgB.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
PIRSFiPIRSF000463. GlgB. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLGB_CUPNJ
AccessioniPrimary (citable) accession number: Q46TF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.