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Q46S32

- TYPH2_CUPPJ

UniProt

Q46S32 - TYPH2_CUPPJ

Protein

Putative thymidine phosphorylase 2

Gene

Reut_B4704

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-4780-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative thymidine phosphorylase 2UniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPase 2UniRule annotation
    Gene namesi
    Ordered Locus Names:Reut_B4704
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Putative thymidine phosphorylase 2PRO_0000314711Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264198.Reut_B4704.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46S32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiRVECAIT.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46S32-1 [UniParc]FASTAAdd to Basket

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    MQANELKLAA GEGQGSEPLI FKPLGIDTWQ EHVIYLHPDC PVCRAEGFTA    50
    QARVQVRIGE ASLIATLNLV GAPLLDTGEA SLSASAAQAL EARAGDVVAI 100
    SHAPALESVR ALRAKIYGRR LDGAQIDSII SDISAGRYPD VYISAFLAAC 150
    ADGRMNRRET VDLTRAMVHS GERLSWSHAV VADKHCVGGL PGNRTTPIVV 200
    AIAAAGGLVL PKTSSRAITS PAGTADTMET LTRVALSAAE LRHVVERVGA 250
    SLVWGGALNL SPADDILIRV ERALDIDSDA QLVASILSKK VAAGSTHILI 300
    DVPVGPTAKV REDRDLERLE AAMRHVAGAF GLHILMVRTD GTQPLGRGIG 350
    PALEARDILA VLQRTVAAPP DLRERSVMLA GALLEFCGAA PRGAGEKAAG 400
    QLLDSGAAWR KFQAICEAQG GLRVPGEAIF RRDIVAPHAG KVIAIDNRHI 450
    ARTAKLAGAP MRQVAGLEMR VRVNDEVRAG QPLFTVHAQA SGELDYSCSY 500
    ALAHPAVSIE PH 512
    Length:512
    Mass (Da):53,921
    Last modified:September 13, 2005 - v1
    Checksum:i8CCDB5A89B7907E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000091 Genomic DNA. Translation: AAZ64052.1.
    RefSeqiYP_298896.1. NC_007348.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ64052; AAZ64052; Reut_B4704.
    GeneIDi3613942.
    KEGGireu:Reut_B4704.
    PATRICi20235285. VBIRalEut24049_5444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000091 Genomic DNA. Translation: AAZ64052.1 .
    RefSeqi YP_298896.1. NC_007348.1.

    3D structure databases

    ProteinModelPortali Q46S32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_B4704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ64052 ; AAZ64052 ; Reut_B4704 .
    GeneIDi 3613942.
    KEGGi reu:Reut_B4704.
    PATRICi 20235285. VBIRalEut24049_5444.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi RVECAIT.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    BioCyci CPIN264198:GIW3-4780-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197.

    Entry informationi

    Entry nameiTYPH2_CUPPJ
    AccessioniPrimary (citable) accession number: Q46S32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3