Q46QB2 (GLK_CUPPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	Reut_B5327

Organism

Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP MF_00524
Subcellular location	Cytoplasm By similarity HAMAP MF_00524.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Glucokinase HAMAP MF_00524		PRO_0000268780
Regions
	Nucleotide binding	21 – 26	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q46QB2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: DDC0B2E1ACE82FA7	FASTA	343	35,393
	10 20 30 40 50 60 MSNAMAASAV PDDTAYPRLL ADVGGTNVRF ALETAPMQIG AVTALKVADH PSLEAAMRHY 70 80 90 100 110 120 RDALSASGAK LPRHAAIGLA NPVTGDHVRL TNHDWAFSIE ATRQALGLQT LVAINDFTSL 130 140 150 160 170 180 ALGLPYLGAN DLVQIRSGQA VATAPRALIG PGTGLGVSGL VPAPGGGAVA LAGEGGHIEL 190 200 210 220 230 240 MPVTDDEWIA WRATHASLGR VSAERLLSGM GLSQIHAALS AETGTRVDVP LTPEQVTTGA 250 260 270 280 290 300 FARHDPLCER TMAVFFGLLG SVAADIALVM GALGGVYLGG GILPRFVPAL QASAFNARFV 310 320 330 340 AKGRMRGYLD KLPVYVITAS YPALPGLARA LADTLSHGRP HIG

References

[1]

"Complete sequence of chromosome 2 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JMP134 / LMG 1197.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000091 Genomic DNA. Translation: AAZ64672.1.
RefSeq	YP_299516.1. NC_007348.1.
3D structure databases
ProteinModelPortal	Q46QB2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46QB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3612765.
GenomeReviews	Gene locus Reut_B5327 in contig CP000091_GR.
KEGG	reu:Reut_B5327.
NMPDR	fig|264198.3.peg.4854.
PATRIC	20236587. VBIRalEut24049_6095.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644410.
OMA	FADKGCM.
ProtClustDB	CLSK769004.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_B5327-MONOMER.
Family and domain databases
HAMAP	MF_00524. Glucokinase. [Tree]
InterPro	IPR003836. Glucokinase. [Graphical view]
KO	K00845.
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. Glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_CUPPJ

Accession

Primary (citable) accession number: Q46QB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program