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Reviewed, UniProtKB/Swiss-Prot Q46PT7 (3HAO_RALEJ)

Last modified June 16, 2009. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO
Gene names
Ordered Locus Names: Reut_B5502
OrganismRalstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]
Taxonomic identifier264198 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

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Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the 3-HAO family.

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Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: HAMAP

ferrous iron binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1891893-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825
PRO_0000245476

Sites

Metal binding531Iron 1; catalytic By similarity
Metal binding591Iron 1; catalytic By similarity
Metal binding971Iron 1; catalytic By similarity
Metal binding1271Iron 2 By similarity
Metal binding1301Iron 2 By similarity
Metal binding1651Iron 2 By similarity
Metal binding1681Iron 2 By similarity
Binding site491Dioxygen By similarity
Binding site591Substrate By similarity
Binding site1011Substrate By similarity
Binding site1121Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q46PT7-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: F3EE0A8DCEEEB74E

FASTA18921,938
        10         20         30         40         50         60 
MFDLKYGRPL NFKRWLDDHA DKLKPPVGNQ QIWQDSDMMV TVVGGPNERS DFHDDPIEEL 

        70         80         90        100        110        120 
FYQFKGNAYL LLWEDGRYER VDLREGDMLL LPPHTLHSPQ RPEADSRCLV VERKRPQGQN 

       130        140        150        160        170        180 
DAFQWSCASC GTIVQRHEVT LQSIVADLPP LYEKFYASSE DARRCPGCGE IHPGRDFQAW 


HRTLARHSS

« Hide

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References

[1]"Complete sequence of chromosome 2 of Ralstonia eutropha JMP134."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000091 Genomic DNA. Translation: AAZ64847.1.
RefSeqYP_299691.1.

3D structure databases

SMRQ46PT7. Positions 4-175.
ModBaseSearch...

Genome annotation databases

GeneID3614547.
GenomeReviewsGene locus Reut_B5502 in contig CP000091_GR.
KEGGreu:Reut_B5502.
NMPDRfig|264198.3.peg.6202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ46PT7.
OMAQ46PT7. RHSPQRP.

Enzyme and pathway databases

BioCycREUT264198:REUT_B5502-MON.

Family and domain databases

HAMAPMF_00825.
[Tree]
InterProIPR010329. 3hydroanth_dOase.
[Graphical view]
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

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Entry information

Entry name3HAO_RALEJ
AccessionPrimary (citable) accession number: Q46PT7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: September 13, 2005
Last modified: June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents