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Q46PT7

- 3HAO_CUPPJ

UniProt

Q46PT7 - 3HAO_CUPPJ

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene
nbaC, Reut_B5502
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Dioxygen By similarity
Metal bindingi53 – 531Iron 1; catalytic By similarity
Metal bindingi59 – 591Iron 1; catalytic By similarity
Binding sitei59 – 591Substrate By similarity
Metal bindingi97 – 971Iron 1; catalytic By similarity
Binding sitei101 – 1011Substrate By similarity
Binding sitei112 – 1121Substrate By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi130 – 1301Iron 2 By similarity
Metal bindingi165 – 1651Iron 2 By similarity
Metal bindingi168 – 1681Iron 2 By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-5579-MONOMER.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
Name:nbaC
Ordered Locus Names:Reut_B5502
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1891893-hydroxyanthranilate 3,4-dioxygenaseUniRule annotationPRO_0000245476Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264198.Reut_B5502.

Structurei

3D structure databases

ProteinModelPortaliQ46PT7.
SMRiQ46PT7. Positions 4-175.

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG6PW234.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46PT7-1 [UniParc]FASTAAdd to Basket

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MFDLKYGRPL NFKRWLDDHA DKLKPPVGNQ QIWQDSDMMV TVVGGPNERS    50
DFHDDPIEEL FYQFKGNAYL LLWEDGRYER VDLREGDMLL LPPHTLHSPQ 100
RPEADSRCLV VERKRPQGQN DAFQWSCASC GTIVQRHEVT LQSIVADLPP 150
LYEKFYASSE DARRCPGCGE IHPGRDFQAW HRTLARHSS 189
Length:189
Mass (Da):21,938
Last modified:September 13, 2005 - v1
Checksum:iF3EE0A8DCEEEB74E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000091 Genomic DNA. Translation: AAZ64847.1.
RefSeqiWP_011301610.1. NC_007348.1.
YP_299691.1. NC_007348.1.

Genome annotation databases

EnsemblBacteriaiAAZ64847; AAZ64847; Reut_B5502.
GeneIDi3614547.
KEGGireu:Reut_B5502.
PATRICi20236965. VBIRalEut24049_6284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000091 Genomic DNA. Translation: AAZ64847.1 .
RefSeqi WP_011301610.1. NC_007348.1.
YP_299691.1. NC_007348.1.

3D structure databases

ProteinModelPortali Q46PT7.
SMRi Q46PT7. Positions 4-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_B5502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ64847 ; AAZ64847 ; Reut_B5502 .
GeneIDi 3614547.
KEGGi reu:Reut_B5502.
PATRICi 20236965. VBIRalEut24049_6284.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG6PW234.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .
BioCyci CPIN264198:GIW3-5579-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.

Entry informationi

Entry namei3HAO_CUPPJ
AccessioniPrimary (citable) accession number: Q46PT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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