ID   MHPF_RALEJ              Reviewed;         313 AA.
AC   Q46NW7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Acetaldehyde dehydrogenase;
DE            EC=1.2.1.10;
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating];
GN   Name=mhpF; OrderedLocusNames=Reut_B5824;
OS   Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M.,
RA   Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 2 of Ralstonia eutropha JMP134.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the terminal reaction in meta-cleavage
CC       pathways, that is, the transformation of acetaldehyde into acetyl
CC       coenzyme A (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD(+) = acetyl-CoA +
CC       NADH.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid
CC       degradation.
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family. MhpF
CC       subfamily.
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DR   EMBL; CP000091; AAZ65167.1; -; Genomic_DNA.
DR   RefSeq; YP_300011.1; -.
DR   SMR; Q46NW7; 4-313.
DR   GeneID; 3614066; -.
DR   GenomeReviews; CP000091_GR; Reut_B5824.
DR   KEGG; reu:Reut_B5824; -.
DR   NMPDR; fig|264198.3.peg.6472; -.
DR   HOGENOM; Q46NW7; -.
DR   OMA; Q46NW7; HVKNDAF.
DR   BioCyc; REUT264198:REUT_B5824-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) ac...; IEA:HAMAP.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01657; -; 1.
DR   InterPro; IPR003361; Acetaldehyde_dehydrogenase.
DR   InterPro; IPR015426; Acetylaldehyde_DH_C.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   PANTHER; PTHR21123; Acetylald_dh; 1.
DR   Pfam; PF09290; AcetDehyd-dimer; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR   TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Complete proteome; NAD;
KW   Oxidoreductase.
FT   CHAIN         1    313       Acetaldehyde dehydrogenase.
FT                                /FTId=PRO_0000337984.
SQ   SEQUENCE   313 AA;  32655 MW;  2BF10617F942ED0F CRC64;
     MATRKLKAAI IGSGNIGTDL MIKILRHGKH LEMGAMVGID PASDGLARAA RMGVATTHEG
     VEGLISLPNF ADIDVVFDAT SAGAHVKNDA RLREVKPGIR MIDLTPAAIG PYCVPVVNLD
     DRLDALNVNM VTCGGQATIP MVAAVSRVAK VHYAEIVASI SSKSAGPGTR ANIDEFTETT
     SKAIEVIGGA AKGKAIIVLN PAEPPLIMRD TVYVLSAAAN RAEVEASIEE MAAAVQQYVP
     GYRLKQKVQF DEIPASAPLN IPGLGKFSGL KTSVFLEVEG AAHYLPAYAG NLDIMTSAAL
     ATAERMAQAA LTA
//