Reviewed, UniProtKB/Swiss-Prot Q46NW7 (ACDH_RALEJ)

Names and origin

Protein names

Recommended name:
    Acetaldehyde dehydrogenase
    EC=1.2.1.10
Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]

Gene names

Ordered Locus Names:

Reut_B5824

Organism

Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]

Taxonomic identifier

264198 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000337984

Sequences

	Sequence		Length	Mass (Da)
	Q46NW7-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 2BF10617F942ED0F	FASTA	313	32,655
	10 20 30 40 50 60 MATRKLKAAI IGSGNIGTDL MIKILRHGKH LEMGAMVGID PASDGLARAA RMGVATTHEG 70 80 90 100 110 120 VEGLISLPNF ADIDVVFDAT SAGAHVKNDA RLREVKPGIR MIDLTPAAIG PYCVPVVNLD 130 140 150 160 170 180 DRLDALNVNM VTCGGQATIP MVAAVSRVAK VHYAEIVASI SSKSAGPGTR ANIDEFTETT 190 200 210 220 230 240 SKAIEVIGGA AKGKAIIVLN PAEPPLIMRD TVYVLSAAAN RAEVEASIEE MAAAVQQYVP 250 260 270 280 290 300 GYRLKQKVQF DEIPASAPLN IPGLGKFSGL KTSVFLEVEG AAHYLPAYAG NLDIMTSAAL 310 ATAERMAQAA LTA

References

[1]

"Complete sequence of chromosome 2 of Ralstonia eutropha JMP134." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000091 Genomic DNA. Translation: AAZ65167.1.
RefSeq	YP_300011.1.
3D structure databases
SMR	Q46NW7. Positions 4-313.
ModBase	Search...
Genome annotation databases
GeneID	3614066.
GenomeReviews	Gene locus Reut_B5824 in contig CP000091_GR.
KEGG	reu:Reut_B5824.
NMPDR	fig|264198.3.peg.6472.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q46NW7.
OMA	HVKNDAF.
Enzyme and pathway databases
BioCyc	REUT264198:REUT_B5824-MON.
Family and domain databases
HAMAP	MF_01657. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_RALEJ

Accession

Primary (citable) accession number: Q46NW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)