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Reviewed, UniProtKB/Swiss-Prot Q46N53 (HISX2_RALEJ)

Last modified February 9, 2010. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase 2
      Short name=HDH 2
    EC=1.1.1.23
Gene names
Name: hisD2
Ordered Locus Names: Reut_C6092
Encoded onPlasmid megaplasmid Reut
OrganismRalstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [Complete proteome] [HAMAP]
Taxonomic identifier264198 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

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Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Histidinol dehydrogenase 2 HAMAP MF_01024
PRO_0000135827

Sites

Active site3181Proton acceptor By similarity
Active site3191Proton acceptor By similarity
Metal binding2481Zinc By similarity
Metal binding2511Zinc By similarity
Metal binding3521Zinc By similarity
Metal binding4111Zinc By similarity
Binding site1181NAD By similarity
Binding site1801NAD By similarity
Binding site2031NAD By similarity
Binding site2261Substrate By similarity
Binding site2481Substrate By similarity
Binding site2511Substrate By similarity
Binding site3191Substrate By similarity
Binding site3521Substrate By similarity
Binding site4061Substrate By similarity
Binding site4111Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q46N53-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: E505337929A7046C

FASTA43646,881
        10         20         30         40         50         60 
MISYLKKAEK TPQTETATAQ KVVTEMLAEI QARGKDAVRQ YAKQLDGWSG DIVLTPDQIR 

        70         80         90        100        110        120 
EQTKDVPAGV RADIDFAIRQ VTDFALAQRE SLKEFSVELH PGVTAGQRVL PVNVVGCYAP 

       130        140        150        160        170        180 
AGRYAHIASA YMGVATAKAA GVKTVVACSS PFRGQGIHPH VLYAFQAAGA DVIMALGGVQ 

       190        200        210        220        230        240 
AIASMAYGLF TGKPADVVVG PGNKFVAEAK RSLYGQVGID VFAGPSEVAV IADETADPAI 

       250        260        270        280        290        300 
VASDLVGQAE HGHESPAWLF TTSRDLADRV MALVPELIAK LPPTARDAAT AAWRDYGEVI 

       310        320        330        340        350        360 
LCGTREEVVE ISDRYASEHL EVHTADLDWW LANLTCYGSL FLGEETTVAF GDKTSGPNHV 

       370        380        390        400        410        420 
LPTKGAARYS GGLSVHKFMK TLTWQQMTRE ATRQIGQVTA RISRLEGMEA HARTADDRMA 

       430 
KYFPNASFEM GTPVEV

« Hide

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References

[1]"Complete sequence of a megaplasmid of Ralstonia eutropha JMP134."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Vergez L., Larimer F., Land M., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000092 Genomic DNA. Translation: AAZ65418.1.
RefSeqYP_293275.1.

3D structure databases

SMRQ46N53. Positions 13-422.
ModBaseSearch...

Genome annotation databases

GeneID3607398.
GenomeReviewsGene locus Reut_C6092 in contig CP000092_GR.
KEGGreu:Reut_C6092.
NMPDRfig|264198.3.peg.6.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG329596.
OMACYGSLFL.

Enzyme and pathway databases

BioCycREUT264198:REUT_C6092-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH_prok-type.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX2_RALEJ
AccessionPrimary (citable) accession number: Q46N53
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents