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Protein

1,4-alpha-glucan branching enzyme GlgB

Gene

glgB

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.UniRule annotation

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei431 – 4311NucleophileUniRule annotation
Active sitei484 – 4841Proton donorUniRule annotation

GO - Molecular functioni

  1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
  2. cation binding Source: InterPro
  3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-646-MONOMER.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan branching enzyme GlgBUniRule annotation (EC:2.4.1.18UniRule annotation)
Alternative name(s):
1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferaseUniRule annotation
Alpha-(1->4)-glucan branching enzymeUniRule annotation
Glycogen branching enzymeUniRule annotation
Short name:
BEUniRule annotation
Gene namesi
Name:glgBUniRule annotation
Ordered Locus Names:PMN2A_0020
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7557551,4-alpha-glucan branching enzyme GlgBPRO_0000260675Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi59920.PMN2A_0020.

Structurei

3D structure databases

ProteinModelPortaliQ46LW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0296.
HOGENOMiHOG000283037.
KOiK00700.
OMAiYWFEQFH.
OrthoDBiEOG6JX7GT.
PhylomeDBiQ46LW6.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_00685. GlgB.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 2 hits.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 2 hits.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46LW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSILLDSL KDDGQRLSEC RHESPFSILG PQPFKDKWII RIWMPEASQV
60 70 80 90 100
ELVTQQTKIK LQNPNHEWIF EGVLEKDPGT DYQIKVNRGG IEHVQHDPWS
110 120 130 140 150
FRKEWMGEID RHLFAEGNHH HIWRKMGAHL TEIDKKKGVM FCLWAPHAKS
160 170 180 190 200
VSVIGDLNSW DGRHHPMQKR LGGIWELFIP GLSEGDLYKY EIRTEKGHCY
210 220 230 240 250
EKADPYGFQH EVRPAKSSVI SKIDSFQWSD QSWISNRDNR DPLEQPISVY
260 270 280 290 300
EMHLGSWMHA SSDDPFINSN GEHRAPVPAA DMKPGSRLLT YKELANKVIP
310 320 330 340 350
YVKERGFTHI ELMPISEHPF DGSWGYQVTG WYAPTSRFGS PDEFRAFVDS
360 370 380 390 400
CHKEGIGIIL DWVPGHFPKD QHGLAYFDGS HLYEHSDPRV GEHKEWGTLI
410 420 430 440 450
FNYSRNEVRN FLVANLIFWF DQFHIDGIRV DAVASMLYKD YLRPEGEWIP
460 470 480 490 500
NEDGGNENFE AVRFLQQANH VLFQHFPGAL SIAEESTTWT GVTKPTDMDG
510 520 530 540 550
LGFNLKWNMG WMHDMLDYFE IDPWFRQFNQ NNITFSICYN FTENFMLALS
560 570 580 590 600
HDEVVHGKSH LLHKMPGDDW QKYANTRALL AYMWTHPGKK TIFMGMEFGQ
610 620 630 640 650
RQEWNVWDDL QWDLLNYEPH KGIQKLVDDL NNLYKREPAL WRNDFDEYGF
660 670 680 690 700
QWIDCDDNKN SVISFMRREK TDGEWLVIVA NFTPQNHSNY RIGVPVDGFY
710 720 730 740 750
EEIFNTDASQ YGGSNLGNMG GKSTDLYNIH GYENSIDLCL PPLSVLVLKH

KSKKN
Length:755
Mass (Da):87,913
Last modified:September 12, 2005 - v1
Checksum:i59B52C5C92E11B8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ57512.1.
RefSeqiWP_011293554.1. NC_007335.2.
YP_291215.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ57512; AAZ57512; PMN2A_0020.
KEGGipmn:PMN2A_0020.
PATRICi23023377. VBIProMar14922_0632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ57512.1.
RefSeqiWP_011293554.1. NC_007335.2.
YP_291215.1. NC_007335.2.

3D structure databases

ProteinModelPortaliQ46LW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59920.PMN2A_0020.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ57512; AAZ57512; PMN2A_0020.
KEGGipmn:PMN2A_0020.
PATRICi23023377. VBIProMar14922_0632.

Phylogenomic databases

eggNOGiCOG0296.
HOGENOMiHOG000283037.
KOiK00700.
OMAiYWFEQFH.
OrthoDBiEOG6JX7GT.
PhylomeDBiQ46LW6.

Enzyme and pathway databases

UniPathwayiUPA00164.
BioCyciPMAR59920:GI1O-646-MONOMER.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_00685. GlgB.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 2 hits.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 2 hits.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiGLGB_PROMT
AccessioniPrimary (citable) accession number: Q46LW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 27, 2006
Last sequence update: September 12, 2005
Last modified: March 31, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.