Q46LT7 (AROA_PROMT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	PMN2A_0049

Organism

Prochlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]

Taxonomic identifier

59920 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325373

Sequences

	Sequence		Length	Mass (Da)
	Q46LT7 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 9818678EE3A0D0CD	FASTA	444	47,514
	10 20 30 40 50 60 MNAPTKDQSL RNLQKGGELC GKVKVPGDKS ISHRALLFGA IAKGKTLIEG LLPAEDPLST 70 80 90 100 110 120 AECLRSMGVK ISPIKKGDII EIEGVGLNGL QEPQDILNCG NSGTTMRLIM GLLAGQKDHH 130 140 150 160 170 180 FILTGDKSLR NRPMKRVGQP LKMMGAKVFG RCGGNLAPLS IIGNKLRGAV IGTPVASAQI 190 200 210 220 230 240 KSAILLAALN AEGSTTVIEP ARSRDHSERM LKAFGANLEV GGEMGRHITV SPGKDLKGQS 250 260 270 280 290 300 IIVPGDISSA AFWLIAGSII PGSELVVENV GLNPTRTGIL DVLEEMEANI NVINKRDVAG 310 320 330 340 350 360 EPVGDIEVFY KENLKPFKID GEIMPRLVDE IPILSVGACF CNGISQIKGA SELRVKETDR 370 380 390 400 410 420 LAVMARQLKR MGASVDEHQD GLTIYGGKSL EGCELDSEDD HRIAMSLAIA SIMANSNSTL 430 440 RRSEAAAISY PDFWSDLKRL QQKN

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000095 Genomic DNA. Translation: AAZ57541.1.
RefSeq	YP_291244.1. NC_007335.2.
3D structure databases
HSSP	HSSP built from PDB template 2AA9 based on UniProtKB P0A6D3.
ProteinModelPortal	Q46LT7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46LT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3605418.
GenomeReviews	Gene locus PMN2A_0049 in contig CP000095_GR.
KEGG	pmn:PMN2A_0049.
PATRIC	23023435. VBIProMar14922_0661.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GEDPRST.
PhylomeDB	Q46LT7.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	PMAR59920:PMN2A_0049-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_PROMT

Accession

Primary (citable) accession number: Q46LT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program