Q46LE1 (LPXD_PROMT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	PMN2A_0195

Organism

Prochlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]

Taxonomic identifier

59920 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264409
Sites
	Active site	251	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46LE1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5E5600D41E9D18D0	FASTA	350	36,865
	10 20 30 40 50 60 MQFIEIVEKL KKGQSGVVDF KIKNNPVILT AASLENAKDN DISFLDNNSP LNLRNLIETS 70 80 90 100 110 120 KASALLLPAN DTYIIEIAKK ISVDWIILKE PKIAFAETLE FLYPSNVESE GIHKSAVIGQ 130 140 150 160 170 180 NVKIGLGVSI GANAYIGDNT EIGAGTIIHA GVVLYRNVRI GSKNLIHANS VIHSGSKLGD 190 200 210 220 230 240 KCVINANAVI GGEGFGFVPT SNGWKKMPQV GIVILKNKVE VGSGSTIDRP SVGETIIGED 250 260 270 280 290 300 TKIDNLVQIG HGVTTGKGCA MAAQVGIAGG AQIGDGVILA GQVGISNRVK IGDGVIASSK 310 320 330 340 350 TGIVSNIEAG TVVSGFPAIP NKLWLRCSAN FKKLPEIAKA IRQLDRKKSR

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000095 Genomic DNA. Translation: AAZ57687.1.
RefSeq	YP_291390.1. NC_007335.2.
3D structure databases
ProteinModelPortal	Q46LE1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46LE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3605565.
GenomeReviews	Gene locus PMN2A_0195 in contig CP000095_GR.
KEGG	pmn:PMN2A_0195.
PATRIC	23023755. VBIProMar14922_0820.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	SYPAKIM.
PhylomeDB	Q46LE1.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	PMAR59920:PMN2A_0195-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_PROMT

Accession

Primary (citable) accession number: Q46LE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program