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Q46LE0

- PROB_PROMT

UniProt

Q46LE0 - PROB_PROMT

Protein

Glutamate 5-kinase

Gene

proB

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71ATPUniRule annotation
    Binding sitei47 – 471SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Binding sitei146 – 1461Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi166 – 1672ATPUniRule annotation
    Nucleotide bindingi208 – 2147ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59920:GI1O-835-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:PMN2A_0196
    OrganismiProchlorococcus marinus (strain NATL2A)
    Taxonomic identifieri59920 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Glutamate 5-kinasePRO_0000230054Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59920.PMN2A_0196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46LE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini273 – 34472PUAUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation
    Contains 1 PUA domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246369.
    KOiK00931.
    OMAiMRMIAGH.
    OrthoDBiEOG6PGK7G.
    PhylomeDBiQ46LE0.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SMARTiSM00359. PUA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46LE0-1 [UniParc]FASTAAdd to Basket

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    MTTWVIKIGT SLLRGNDKYT TFDVINDYCS YISKAQRNGD KIILVSSGAV    50
    GLGCHQMRFK TRPKEIISLQ ASAAIGQLHL MALYEKAMSS FGYKVAQILL 100
    TRSELGSRNS YNSASQTLKR LLEWDVIPIV NENDITSDEE LKYGDNDTLS 150
    ALVATAISAD QLILLTDIDH LYSSDPKINS KAKPIKDINN SKELNNLELA 200
    NEQTSWGTGG IKTKLTAAKI ATESGIKVQL ADGRDPKILG ELLDGKKIGT 250
    VFHPNPNPIG NRKSWLAHAI KPVGEIHLDD GASEAIKNKG ASLLLVGVKK 300
    VSGDFIANQP VKVINTEGEE FAKGICSMSS DAIKIGINSR SETTGSPLVI 350
    HRDVLVLTSE 360
    Length:360
    Mass (Da):39,032
    Last modified:September 13, 2005 - v1
    Checksum:i98C3A1C47895F51E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ57688.1.
    RefSeqiWP_011293730.1. NC_007335.2.
    YP_291391.1. NC_007335.2.

    Genome annotation databases

    EnsemblBacteriaiAAZ57688; AAZ57688; PMN2A_0196.
    GeneIDi3605566.
    KEGGipmn:PMN2A_0196.
    PATRICi23023757. VBIProMar14922_0821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ57688.1 .
    RefSeqi WP_011293730.1. NC_007335.2.
    YP_291391.1. NC_007335.2.

    3D structure databases

    ProteinModelPortali Q46LE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59920.PMN2A_0196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ57688 ; AAZ57688 ; PMN2A_0196 .
    GeneIDi 3605566.
    KEGGi pmn:PMN2A_0196.
    PATRICi 23023757. VBIProMar14922_0821.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246369.
    KOi K00931.
    OMAi MRMIAGH.
    OrthoDBi EOG6PGK7G.
    PhylomeDBi Q46LE0.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci PMAR59920:GI1O-835-MONOMER.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SMARTi SM00359. PUA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL2A.

    Entry informationi

    Entry nameiPROB_PROMT
    AccessioniPrimary (citable) accession number: Q46LE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3