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Q46LA9 (Q46LA9_PROMT) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase HAMAP MF_01840
EC=1.14.13.81 HAMAP MF_01840
Gene names
Name:acsF HAMAP MF_01840
Ordered Locus Names:PMN2A_0227
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP] EMBL AAZ57719.1
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840

Catalytic activity

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

Cofactor

Iron By similarity. HAMAP MF_01840

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840

Sequence similarities

Belongs to the AcsF family. HAMAP MF_01840

Sequences

Sequence LengthMass (Da)Tools
Q46LA9 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 605F4BF6D136C3B2

FASTA36843,014
        10         20         30         40         50         60 
MTATASSSPK LRVDTRGTNE LPPHLDENLL TPRFYVTEFK KAAKTELTDA REEFEAMLSE 

        70         80         90        100        110        120 
MKADYNCTHF DRKASLDRLQ ELPQKAKETY ESYLVRSVIS EFSGFLLFKE ISNRLKKEGN 

       130        140        150        160        170        180 
RDLGKLFQFL ARDEARHAGF LSRALVAEGI EVDLPHLGGK RAATWFPISW VIYSVYLSEK 

       190        200        210        220        230        240 
IGYWRYILMD RHLKANPDQA FAPLFDFFEP WCQDENRHGD CFTVMMRCWP GITKGFRGKL 

       250        260        270        280        290        300 
LSRFFLWSVF LTHTLTVCER GEFYELLGID PKEFDEEVIK RTNHTSKNAF PWVFNLDDNK 

       310        320        330        340        350        360 
FWDLRNKIIE SFRAFVGAKG LTKPVKFVKF ATLIFKQFAL PMEKTDALRY DKNVNFTGQD 


ILNFWTDK

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000095 Genomic DNA. Translation: AAZ57719.1.
RefSeqYP_291422.1. NC_007335.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ46LA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3605598.
GenomeReviewsGene locus PMN2A_0227 in contig CP000095_GR.
KEGGpmn:PMN2A_0227.
PATRIC23023821. VBIProMar14922_0852.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHBG284843.
OMANRHGDIF.
PhylomeDBQ46LA9.
ProtClustDBPRK13654.

Enzyme and pathway databases

BioCycPMAR59920:PMN2A_0227-MONOMER.

Family and domain databases

HAMAPMF_01840. AcsF.
[Tree]
InterProIPR008434. AcsF.
IPR012347. Ferritin-rel.
IPR009078. Ferritin/RR-like.
IPR003251. Rubrerythrin.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KOK04035.
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ46LA9_PROMT
AccessionPrimary (citable) accession number: Q46LA9
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info