Q46L16 (G6PI_PROMT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	PMN2A_0320

Organism

Prochlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]

Taxonomic identifier

59920 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence AAZ57812.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000230926
Sites
	Active site	322	1	Proton donor By similarity
	Active site	351	1	By similarity
	Active site	453	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46L16 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: EA6E01B3F90E16D7	FASTA	524	58,233
	10 20 30 40 50 60 MNNNDKWARY CDLLYSDDSL GFWLDISRMD VAINDFEDFN EIYSKAFDAL ESLENGSIAN 70 80 90 100 110 120 IDEGRQVGHY WLRNPKVAPS PEISDSITKE IQDISKFGSS ILNGEITNSD GEKYTDVFWI 130 140 150 160 170 180 GIGGSGLGPL LIKESFKRES IGLDLHFLDN VDPEGISHKL NSILPNLNST LFVVVSKSGG 190 200 210 220 230 240 TPEPLIGMEQ AMKFVRDNNQ NWSSRAIAIT SKGSKLDLLA HNENWLDIFD LPDWVGGRTS 250 260 270 280 290 300 ITGAVGLLPA ALIGADINKF LNGASQMDAL TRVKDIKNNP AALLSLAWFK SGNGKGLRDM 310 320 330 340 350 360 VVLPYRDRLE VFSRYLQQLV MESLGKKFDR DENQVNQGIA VYGNKGSTDQ HAYVQQLRDG 370 380 390 400 410 420 IDNFFVNFIE ILHDPLEIVE VKNKRPGDYL SGFLQGTRSA LTEGGRQNLT ITFKSFDESS 430 440 450 460 470 480 LGALIALFER AVSLYAELIN VNAYNQPGVE AGKKAATKII KLQKEIEELL DDGKQRTLNE 490 500 510 520 INDALSSDST ESIYLILRKL SENSDHYSMI GNQSNPDKLI ISKT

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000095 Genomic DNA. Translation: AAZ57812.1. Different initiation.
RefSeq	YP_291515.1. NC_007335.2.
3D structure databases
ProteinModelPortal	Q46L16.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46L16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3605693.
GenomeReviews	Gene locus PMN2A_0320 in contig CP000095_GR.
KEGG	pmn:PMN2A_0320.
PATRIC	23024027. VBIProMar14922_0953.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG285902.
OMA	RTSITSA.
PhylomeDB	Q46L16.
ProtClustDB	PRK14096.
Enzyme and pathway databases
BioCyc	PMAR59920:PMN2A_0320-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_PROMT

Accession

Primary (citable) accession number: Q46L16

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program