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Q46L16 (G6PI_PROMT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:PMN2A_0320
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00473

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAZ57812.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000230926

Sites

Active site3221Proton donor By similarity
Active site3511 By similarity
Active site4531 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q46L16 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: EA6E01B3F90E16D7

FASTA52458,233
        10         20         30         40         50         60 
MNNNDKWARY CDLLYSDDSL GFWLDISRMD VAINDFEDFN EIYSKAFDAL ESLENGSIAN 

        70         80         90        100        110        120 
IDEGRQVGHY WLRNPKVAPS PEISDSITKE IQDISKFGSS ILNGEITNSD GEKYTDVFWI 

       130        140        150        160        170        180 
GIGGSGLGPL LIKESFKRES IGLDLHFLDN VDPEGISHKL NSILPNLNST LFVVVSKSGG 

       190        200        210        220        230        240 
TPEPLIGMEQ AMKFVRDNNQ NWSSRAIAIT SKGSKLDLLA HNENWLDIFD LPDWVGGRTS 

       250        260        270        280        290        300 
ITGAVGLLPA ALIGADINKF LNGASQMDAL TRVKDIKNNP AALLSLAWFK SGNGKGLRDM 

       310        320        330        340        350        360 
VVLPYRDRLE VFSRYLQQLV MESLGKKFDR DENQVNQGIA VYGNKGSTDQ HAYVQQLRDG 

       370        380        390        400        410        420 
IDNFFVNFIE ILHDPLEIVE VKNKRPGDYL SGFLQGTRSA LTEGGRQNLT ITFKSFDESS 

       430        440        450        460        470        480 
LGALIALFER AVSLYAELIN VNAYNQPGVE AGKKAATKII KLQKEIEELL DDGKQRTLNE 

       490        500        510        520 
INDALSSDST ESIYLILRKL SENSDHYSMI GNQSNPDKLI ISKT 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000095 Genomic DNA. Translation: AAZ57812.1. Different initiation.
RefSeqYP_291515.1. NC_007335.2.

3D structure databases

ProteinModelPortalQ46L16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59920.PMN2A_0320.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ57812; AAZ57812; PMN2A_0320.
GeneID3605693.
KEGGpmn:PMN2A_0320.
PATRIC23024027. VBIProMar14922_0953.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000131425.
KOK01810.
OMAFTDVLWI.
OrthoDBEOG64R61J.
PhylomeDBQ46L16.

Enzyme and pathway databases

BioCycPMAR59920:GI1O-970-MONOMER.
UniPathwayUPA00109; UER00181.
UPA00138.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_PROMT
AccessionPrimary (citable) accession number: Q46L16
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways