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Q46L15

- SYL_PROMT

UniProt

Q46L15 - SYL_PROMT

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-971-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PMN2A_0321
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligasePRO_0000334792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_0321.

Structurei

3D structure databases

ProteinModelPortaliQ46L15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionAdd
BLAST
Motifi624 – 6285"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.
PhylomeDBiQ46L15.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46L15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNTTSDIND QRYEPREVEA YWQKEWASDD LYRTNTEVNK ENTFYALSMF
60 70 80 90 100
PYPSGSLHMG HVRNYVITDV LARYKRMKGF NVLHPMGWDS FGLPAENAAI
110 120 130 140 150
EREISPSTWT DKNISQMKDQ LDRLGLSIDW SKEVTTCKEE YYKWTQYIFN
160 170 180 190 200
QLHKNNLAYQ KKATVNWDPI DQTVLANEQV DAEGKSWRSG AKVEKKELNQ
210 220 230 240 250
WFLRITSFAE DLNKDLIKLN DWPDRVRVMQ KNWIGKSIGA EITFEIKNSD
260 270 280 290 300
QKITAFTTRI DTVYGVSYLV LASNHPLIDQ LISSNDIDKL NDFRQTQEKL
310 320 330 340 350
SDLERNSDTR QKLGMYLGVD AINPANNKEI PIWIGDYVIM EYGTGAVMGV
360 370 380 390 400
PAHDSRDYQF AKSYDLPIQY VIKPNIDEDE SYLNAEFVDK GIMINSDKFN
410 420 430 440 450
GIESDIAKTQ ILEFGSNSNW AKPKITYKLR DWLISRQRYW GCPIPIINCK
460 470 480 490 500
KCGQVRVPDN DLPVVLPIDI KLTGKGKSPL TTKTEWINTC CPKCGTEAKR
510 520 530 540 550
ETDTMDTFMC SSWYFLRYIN PDNCEKPFLK SEIDKWLPVK QYVGGIEHAI
560 570 580 590 600
LHLLYSRFLT KALKKCGLIN IDEPFKKLLT QGMVQAVTFK NPNTNKYFSK
610 620 630 640 650
DQIKDIDNPK DPLTGENIEI IYEKMSKSKY NGVDPSVVID KYGADTARMF
660 670 680 690 700
ILFKAPPEKD LEWDDSDVEG QYRFIQRLWK FVINTFKLTN NNSRSNIEKE
710 720 730 740 750
KSKDEEALRL INIAIKEITD DLDNLQFNTA ISELMKVVNG LSLIVNYCSN
760 770 780 790 800
ETLNKVISIL VKITSPFSPH IAEELWKTIG NTQSIHLQSW PEFDAGAIEQ
810 820 830 840 850
DTFKLMIQIN GKVRGSINAS KNLSKENLED LAIKTEAAIK WMDGKEPKRI
860
IVVPNKLVNI VI
Length:862
Mass (Da):99,302
Last modified:September 13, 2005 - v1
Checksum:i171CA10B0D90CA7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ57813.1.
RefSeqiYP_291516.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ57813; AAZ57813; PMN2A_0321.
GeneIDi3605694.
KEGGipmn:PMN2A_0321.
PATRICi23024029. VBIProMar14922_0954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ57813.1 .
RefSeqi YP_291516.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46L15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_0321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ57813 ; AAZ57813 ; PMN2A_0321 .
GeneIDi 3605694.
KEGGi pmn:PMN2A_0321.
PATRICi 23024029. VBIProMar14922_0954.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.
PhylomeDBi Q46L15.

Enzyme and pathway databases

BioCyci PMAR59920:GI1O-971-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiSYL_PROMT
AccessioniPrimary (citable) accession number: Q46L15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3