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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei627ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59920:G1G4T-915-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PMN2A_0321
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002535 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347921 – 862Leucine--tRNA ligaseAdd BLAST862

Proteomic databases

PRIDEiQ46L15

Structurei

3D structure databases

ProteinModelPortaliQ46L15
SMRiQ46L15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionAdd BLAST11
Motifi624 – 628"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ
PhylomeDBiQ46L15

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q46L15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNTTSDIND QRYEPREVEA YWQKEWASDD LYRTNTEVNK ENTFYALSMF
60 70 80 90 100
PYPSGSLHMG HVRNYVITDV LARYKRMKGF NVLHPMGWDS FGLPAENAAI
110 120 130 140 150
EREISPSTWT DKNISQMKDQ LDRLGLSIDW SKEVTTCKEE YYKWTQYIFN
160 170 180 190 200
QLHKNNLAYQ KKATVNWDPI DQTVLANEQV DAEGKSWRSG AKVEKKELNQ
210 220 230 240 250
WFLRITSFAE DLNKDLIKLN DWPDRVRVMQ KNWIGKSIGA EITFEIKNSD
260 270 280 290 300
QKITAFTTRI DTVYGVSYLV LASNHPLIDQ LISSNDIDKL NDFRQTQEKL
310 320 330 340 350
SDLERNSDTR QKLGMYLGVD AINPANNKEI PIWIGDYVIM EYGTGAVMGV
360 370 380 390 400
PAHDSRDYQF AKSYDLPIQY VIKPNIDEDE SYLNAEFVDK GIMINSDKFN
410 420 430 440 450
GIESDIAKTQ ILEFGSNSNW AKPKITYKLR DWLISRQRYW GCPIPIINCK
460 470 480 490 500
KCGQVRVPDN DLPVVLPIDI KLTGKGKSPL TTKTEWINTC CPKCGTEAKR
510 520 530 540 550
ETDTMDTFMC SSWYFLRYIN PDNCEKPFLK SEIDKWLPVK QYVGGIEHAI
560 570 580 590 600
LHLLYSRFLT KALKKCGLIN IDEPFKKLLT QGMVQAVTFK NPNTNKYFSK
610 620 630 640 650
DQIKDIDNPK DPLTGENIEI IYEKMSKSKY NGVDPSVVID KYGADTARMF
660 670 680 690 700
ILFKAPPEKD LEWDDSDVEG QYRFIQRLWK FVINTFKLTN NNSRSNIEKE
710 720 730 740 750
KSKDEEALRL INIAIKEITD DLDNLQFNTA ISELMKVVNG LSLIVNYCSN
760 770 780 790 800
ETLNKVISIL VKITSPFSPH IAEELWKTIG NTQSIHLQSW PEFDAGAIEQ
810 820 830 840 850
DTFKLMIQIN GKVRGSINAS KNLSKENLED LAIKTEAAIK WMDGKEPKRI
860
IVVPNKLVNI VI
Length:862
Mass (Da):99,302
Last modified:September 13, 2005 - v1
Checksum:i171CA10B0D90CA7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA Translation: AAZ57813.1
RefSeqiWP_011293855.1, NC_007335.2

Genome annotation databases

EnsemblBacteriaiAAZ57813; AAZ57813; PMN2A_0321
KEGGipmn:PMN2A_0321

Similar proteinsi

Entry informationi

Entry nameiSYL_PROMT
AccessioniPrimary (citable) accession number: Q46L15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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