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Q46L15

- SYL_PROMT

UniProt

Q46L15 - SYL_PROMT

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei627 – 6271ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59920:GI1O-971-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PMN2A_0321
    OrganismiProchlorococcus marinus (strain NATL2A)
    Taxonomic identifieri59920 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Leucine--tRNA ligasePRO_0000334792Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59920.PMN2A_0321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46L15.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6111"HIGH" regionAdd
    BLAST
    Motifi624 – 6285"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.
    PhylomeDBiQ46L15.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46L15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNTTSDIND QRYEPREVEA YWQKEWASDD LYRTNTEVNK ENTFYALSMF    50
    PYPSGSLHMG HVRNYVITDV LARYKRMKGF NVLHPMGWDS FGLPAENAAI 100
    EREISPSTWT DKNISQMKDQ LDRLGLSIDW SKEVTTCKEE YYKWTQYIFN 150
    QLHKNNLAYQ KKATVNWDPI DQTVLANEQV DAEGKSWRSG AKVEKKELNQ 200
    WFLRITSFAE DLNKDLIKLN DWPDRVRVMQ KNWIGKSIGA EITFEIKNSD 250
    QKITAFTTRI DTVYGVSYLV LASNHPLIDQ LISSNDIDKL NDFRQTQEKL 300
    SDLERNSDTR QKLGMYLGVD AINPANNKEI PIWIGDYVIM EYGTGAVMGV 350
    PAHDSRDYQF AKSYDLPIQY VIKPNIDEDE SYLNAEFVDK GIMINSDKFN 400
    GIESDIAKTQ ILEFGSNSNW AKPKITYKLR DWLISRQRYW GCPIPIINCK 450
    KCGQVRVPDN DLPVVLPIDI KLTGKGKSPL TTKTEWINTC CPKCGTEAKR 500
    ETDTMDTFMC SSWYFLRYIN PDNCEKPFLK SEIDKWLPVK QYVGGIEHAI 550
    LHLLYSRFLT KALKKCGLIN IDEPFKKLLT QGMVQAVTFK NPNTNKYFSK 600
    DQIKDIDNPK DPLTGENIEI IYEKMSKSKY NGVDPSVVID KYGADTARMF 650
    ILFKAPPEKD LEWDDSDVEG QYRFIQRLWK FVINTFKLTN NNSRSNIEKE 700
    KSKDEEALRL INIAIKEITD DLDNLQFNTA ISELMKVVNG LSLIVNYCSN 750
    ETLNKVISIL VKITSPFSPH IAEELWKTIG NTQSIHLQSW PEFDAGAIEQ 800
    DTFKLMIQIN GKVRGSINAS KNLSKENLED LAIKTEAAIK WMDGKEPKRI 850
    IVVPNKLVNI VI 862
    Length:862
    Mass (Da):99,302
    Last modified:September 13, 2005 - v1
    Checksum:i171CA10B0D90CA7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ57813.1.
    RefSeqiWP_011293855.1. NC_007335.2.
    YP_291516.1. NC_007335.2.

    Genome annotation databases

    EnsemblBacteriaiAAZ57813; AAZ57813; PMN2A_0321.
    GeneIDi3605694.
    KEGGipmn:PMN2A_0321.
    PATRICi23024029. VBIProMar14922_0954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ57813.1 .
    RefSeqi WP_011293855.1. NC_007335.2.
    YP_291516.1. NC_007335.2.

    3D structure databases

    ProteinModelPortali Q46L15.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59920.PMN2A_0321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ57813 ; AAZ57813 ; PMN2A_0321 .
    GeneIDi 3605694.
    KEGGi pmn:PMN2A_0321.
    PATRICi 23024029. VBIProMar14922_0954.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.
    PhylomeDBi Q46L15.

    Enzyme and pathway databases

    BioCyci PMAR59920:GI1O-971-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL2A.

    Entry informationi

    Entry nameiSYL_PROMT
    AccessioniPrimary (citable) accession number: Q46L15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3