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Q46L15 (SYL_PROMT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:PMN2A_0321
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334792

Regions

Motif51 – 6111"HIGH" region HAMAP-Rule MF_00049
Motif624 – 6285"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6271ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q46L15 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 171CA10B0D90CA7C

FASTA86299,302
        10         20         30         40         50         60 
MNNTTSDIND QRYEPREVEA YWQKEWASDD LYRTNTEVNK ENTFYALSMF PYPSGSLHMG 

        70         80         90        100        110        120 
HVRNYVITDV LARYKRMKGF NVLHPMGWDS FGLPAENAAI EREISPSTWT DKNISQMKDQ 

       130        140        150        160        170        180 
LDRLGLSIDW SKEVTTCKEE YYKWTQYIFN QLHKNNLAYQ KKATVNWDPI DQTVLANEQV 

       190        200        210        220        230        240 
DAEGKSWRSG AKVEKKELNQ WFLRITSFAE DLNKDLIKLN DWPDRVRVMQ KNWIGKSIGA 

       250        260        270        280        290        300 
EITFEIKNSD QKITAFTTRI DTVYGVSYLV LASNHPLIDQ LISSNDIDKL NDFRQTQEKL 

       310        320        330        340        350        360 
SDLERNSDTR QKLGMYLGVD AINPANNKEI PIWIGDYVIM EYGTGAVMGV PAHDSRDYQF 

       370        380        390        400        410        420 
AKSYDLPIQY VIKPNIDEDE SYLNAEFVDK GIMINSDKFN GIESDIAKTQ ILEFGSNSNW 

       430        440        450        460        470        480 
AKPKITYKLR DWLISRQRYW GCPIPIINCK KCGQVRVPDN DLPVVLPIDI KLTGKGKSPL 

       490        500        510        520        530        540 
TTKTEWINTC CPKCGTEAKR ETDTMDTFMC SSWYFLRYIN PDNCEKPFLK SEIDKWLPVK 

       550        560        570        580        590        600 
QYVGGIEHAI LHLLYSRFLT KALKKCGLIN IDEPFKKLLT QGMVQAVTFK NPNTNKYFSK 

       610        620        630        640        650        660 
DQIKDIDNPK DPLTGENIEI IYEKMSKSKY NGVDPSVVID KYGADTARMF ILFKAPPEKD 

       670        680        690        700        710        720 
LEWDDSDVEG QYRFIQRLWK FVINTFKLTN NNSRSNIEKE KSKDEEALRL INIAIKEITD 

       730        740        750        760        770        780 
DLDNLQFNTA ISELMKVVNG LSLIVNYCSN ETLNKVISIL VKITSPFSPH IAEELWKTIG 

       790        800        810        820        830        840 
NTQSIHLQSW PEFDAGAIEQ DTFKLMIQIN GKVRGSINAS KNLSKENLED LAIKTEAAIK 

       850        860 
WMDGKEPKRI IVVPNKLVNI VI 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000095 Genomic DNA. Translation: AAZ57813.1.
RefSeqYP_291516.1. NC_007335.2.

3D structure databases

ProteinModelPortalQ46L15.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59920.PMN2A_0321.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ57813; AAZ57813; PMN2A_0321.
GeneID3605694.
KEGGpmn:PMN2A_0321.
PATRIC23024029. VBIProMar14922_0954.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.
PhylomeDBQ46L15.

Enzyme and pathway databases

BioCycPMAR59920:GI1O-971-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR024909. Cys-tRNA/MSH_ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PROMT
AccessionPrimary (citable) accession number: Q46L15
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries