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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi495MagnesiumUniRule annotation1
Metal bindingi501MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:PMN2A_0810
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002535 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297721 – 722Polyribonucleotide nucleotidyltransferaseAdd BLAST722

Proteomic databases

PRIDEiQ46JM7

Structurei

3D structure databases

ProteinModelPortaliQ46JM7
SMRiQ46JM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 621KHUniRule annotationAdd BLAST60
Domaini631 – 699S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0
PhylomeDBiQ46JM7

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q46JM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGQTKSVSF DGREIKLTTG RFAPQAGGSV MIECGDTSVL VTATKSSGRE
60 70 80 90 100
GVDFLPLMCD YEERLYAAGR IPGSFMRREG RPPERATLIS RLIDRPMRPL
110 120 130 140 150
FPGWMRDDIQ IVATCLSLDE RVPADVLAVT GASMATLMAG IPFQGPMAAV
160 170 180 190 200
RVGLLGDDFV LNPSYREIER GDLDLVVAGT PDGVVMVEAG ANQLSEQDVI
210 220 230 240 250
EAIDFGYEAI TELINAQKEV LKESGIKQEM PKAPEIDDTI STYLDKNCTK
260 270 280 290 300
SISEVLKNFD QTKEERDNKI EEIKISISAK IDGLKDDNAV KKSLSLNNKL
310 320 330 340 350
LENSYKALTK KLMREQIIKE GKRVDGRELN EVRAIDADAA VLPNRVHGSA
360 370 380 390 400
LFQRGLTQVL STATLGTPSD AQEMDDLNPN TDKTYIHHYN FPPYSVGETR
410 420 430 440 450
PMRTPGRREV GHGALAERAL IPVLPAKDTF PYVLRVVSEV LSSNGSTSMA
460 470 480 490 500
SVCGSTLALM DAGVPLKAPV GGAAMGLIKE GKEVRILTDI QGIEDFLGDM
510 520 530 540 550
DFKVAGTEKG ITALQMDMKI TGLPIETIGE AINQALPART HILGKMLDAI
560 570 580 590 600
ETPKDNLSPH APRLLSFRID PELIGTVIGP GGRTIKGITE RTNTKIDIED
610 620 630 640 650
GGIVTIASHD GAAAEEAQRI IEGLTRKVHE GEIFPGSITR IIPIGAFVEI
660 670 680 690 700
LPGKEGMIHI SQLSEARVEK VEDVVKVGDQ VTVRVREIDN RGRINLTLRG
710 720
VSQNGGMSNY PEPTPTPVAP LT
Length:722
Mass (Da):78,259
Last modified:September 13, 2005 - v1
Checksum:i7011A434D0E60576
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA Translation: AAZ58301.1
RefSeqiWP_011294898.1, NC_007335.2

Genome annotation databases

EnsemblBacteriaiAAZ58301; AAZ58301; PMN2A_0810
KEGGipmn:PMN2A_0810

Similar proteinsi

Entry informationi

Entry nameiPNP_PROMT
AccessioniPrimary (citable) accession number: Q46JM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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