Reviewed, UniProtKB/Swiss-Prot Q46JK2 (PPNK1_PROMT)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 1
      Short name=Poly(P)/ATP NAD kinase 1
    EC=2.7.1.23

Gene names

Name:	ppnK1
Ordered Locus Names:	PMN2A_0835

Organism

Prochlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]

Taxonomic identifier

59920 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Probable inorganic polyphosphate/ATP-NAD kinase 1 HAMAP MF_00361		PRO_0000229672

Sequences

	Sequence		Length	Mass (Da)
	Q46JK2-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: A46B1FB4F617788B	FASTA	302	32,833
	10 20 30 40 50 60 MPRVGLIVND GKELAVKTAK TFQKKLEDSG FEVVRVSSAG GLLGFTNPDQ YMSSQGYNSC 70 80 90 100 110 120 IPEGFDSSIL FAVVLGGDGT VLSAARQTAP LGIPILTVNT GHLGFLAEAY LSDIDKIFKH 130 140 150 160 170 180 LVARQWSIEK RTSLVVSVMR GDQCRWEALC LNEMALHREP MTSMCHFEIS VGRHAPVDIS 190 200 210 220 230 240 ADGVILSTPT GSTAYSLSAG GPVITPDCPV LQLTPVSPHS LASRALVFSN EEPVTVFPAT 250 260 270 280 290 300 PERLMMVVDG SAGCYVWPED RVLIRKSDHP VKFIRLSDHE FFQVLRNKLG WGLPHVAKPD KT

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000095 Genomic DNA. Translation: AAZ58326.1.
RefSeq	YP_292029.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q46JK2.
Genome annotation databases
GeneID	3606216.
GenomeReviews	Gene locus PMN2A_0835 in contig CP000095_GR.
KEGG	pmn:PMN2A_0835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q46JK2.
OMA	NDGKELA.
Enzyme and pathway databases
BioCyc	PMAR59920:PMN2A_0835-MON.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK1_PROMT

Accession

Primary (citable) accession number: Q46JK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)