Q46JK0 (SURE_PROMT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	PMN2A_0837

Organism

Prochlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]

Taxonomic identifier

59920 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235636
Sites
	Metal binding	11	1	Divalent metal cation By similarity
	Metal binding	12	1	Divalent metal cation By similarity
	Metal binding	43	1	Divalent metal cation By similarity
	Metal binding	101	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46JK0 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 23E1BA1E2044231F	FASTA	262	28,377
	10 20 30 40 50 60 MKPLKILISN DDGVFAEGIR TLATSAASRG HKVTVVCPDQ ERSATGHGLT LHSPIRAEKA 70 80 90 100 110 120 DELFGGGIKA WGCSGTPADC VKLALNELLD QKPDLILSGI NHGPNLGTDI FCSGTVAAAL 130 140 150 160 170 180 EGTLDGIPSI AVSVASFQWK NFSFAGKLSL DIAEKAIQQN WPKNLLLNLN IPPCEEKEMG 190 200 210 220 230 240 DLVWTRLSIR QYEEQFIRRV DPRGNTYFWM AGEAVKDLQS AGEGPKGWPS DVSQIALCSP 250 260 SLTPIQPDLF WRGNLDDLPN LI

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NATL2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000095 Genomic DNA. Translation: AAZ58328.1.
RefSeq	YP_292031.1. NC_007335.2.
3D structure databases
ProteinModelPortal	Q46JK0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46JK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3606218.
GenomeReviews	Gene locus PMN2A_0837 in contig CP000095_GR.
KEGG	pmn:PMN2A_0837.
PATRIC	23025457. VBIProMar14922_1660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	NGFYYVN.
PhylomeDB	Q46JK0.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	PMAR59920:PMN2A_0837-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_PROMT

Accession

Primary (citable) accession number: Q46JK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program