Q46JD2 (Q46JD2_PROMT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL AAZ58396.1
EC=2.4.1.182 EMBL AAZ58396.1

Gene names

Ordered Locus Names:

PMN2A_0905

Organism

Prochlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP] EMBL AAZ58396.1

Taxonomic identifier

59920 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL AAZ58396.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q46JD2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 6D9755424C63DEDA	FASTA	390	43,487
	10 20 30 40 50 60 MKLLISTGEV SGDLQGSLLI NALKTNAEKR KIELEIIALG GERMQEAGAK LISNTSSIGA 70 80 90 100 110 120 IGFLEALPYV LPTLNAQSKI DNYLSSSPPD AVVLIDYMGP NIRLGLKVKK KFPNIPIIYY 130 140 150 160 170 180 IAPQEWAWRL GDSGTTDLIS FTDKILAIFE EEAKFYSNKG GNVKFVGHPM LDFYRNIPTR 190 200 210 220 230 240 EEALRRIGLT SDQKLLLIIP ASRKQELKYI LPTLLKAAKL LQEKDPSITV LIPSGLNEFN 250 260 270 280 290 300 ELLNDSLKEY ALSGRIILSN EVDDLKPFLF SAAHLALAKS GTINMELALN SVPQIVGYKV 310 320 330 340 350 360 SRVTAFFARY LLRFNVKYIS PVNLLLNKML IPEFIQEDFK ADKIFNAALK ILEDNSTKED 370 380 390 IKLGYERLKD KLGKPGVTDR ASKDILDLLI

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000095 Genomic DNA. Translation: AAZ58396.1.
RefSeq	YP_292099.1. NC_007335.2.
3D structure databases
ProteinModelPortal	Q46JD2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46JD2.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3606290.
GenomeReviews	Gene locus PMN2A_0905 in contig CP000095_GR.
KEGG	pmn:PMN2A_0905.
PATRIC	23025611. VBIProMar14922_1734.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	IGLANIM.
PhylomeDB	Q46JD2.
ProtClustDB	PRK00025.
Enzyme and pathway databases
BioCyc	PMAR59920:PMN2A_0905-MONOMER.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q46JD2_PROMT

Accession

Primary (citable) accession number: Q46JD2

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)