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Q46J19

- HISX_PROMT

UniProt

Q46J19 - HISX_PROMT

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Protein

Histidinol dehydrogenase

Gene
hisD, PMN2A_1019
Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei231 – 2311NAD By similarity
Binding sitei254 – 2541Substrate By similarity
Metal bindingi276 – 2761Zinc By similarity
Binding sitei276 – 2761Substrate By similarity
Metal bindingi279 – 2791Zinc By similarity
Binding sitei279 – 2791Substrate By similarity
Active sitei344 – 3441Proton acceptor By similarity
Active sitei345 – 3451Proton acceptor By similarity
Binding sitei345 – 3451Substrate By similarity
Metal bindingi378 – 3781Zinc By similarity
Binding sitei378 – 3781Substrate By similarity
Binding sitei432 – 4321Substrate By similarity
Metal bindingi437 – 4371Zinc By similarity
Binding sitei437 – 4371Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-1890-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PMN2A_1019
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Histidinol dehydrogenaseUniRule annotationPRO_0000135815Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_1019.

Structurei

3D structure databases

ProteinModelPortaliQ46J19.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ46J19.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46J19-1 [UniParc]FASTAAdd to Basket

« Hide

MTQIINKDEV QETSSKKLTI KTANSIDQAQ FELRKITERT SGTVQDEAIK    50
VVDDILKNVR ERGDEALTEY TSRFDGFLTE KFQVSSDLIL KAWEETPREL 100
QDSLLLAKKR IEKFHSLQVP KNITYTGPNG ETLGRRWSPV EKAGIYVPGG 150
RAAYPSTVLM NAIPAYVAGV NQIIMVSPAN SQGEINQTVL AAAHITGINK 200
IFRLGGAQAI CALASGTESI PKVDVITGPG NIYVTLAKKK VYGKVGIDSL 250
AGPSEILIIA DQSAKLEHVA SDMLAQSEHD PLASAILITT NTKLAEKLPA 300
EINRQLINHP RLKICQESIS NWGLIVLCDD LETCAQLSDT FAPEHLELLV 350
EDPKKLSESI NNAGAIFMGP WSPEAIGDYL GGPNHTLPTS GTARFAGALG 400
VETFMKNTSL IDFSKEAFNE NKNAVVQLAN SEGLHSHAES IRIRDSKSF 449
Length:449
Mass (Da):48,862
Last modified:September 13, 2005 - v1
Checksum:iE8D895AE8A088870
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58509.1.
RefSeqiWP_011295364.1. NC_007335.2.
YP_292212.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ58509; AAZ58509; PMN2A_1019.
GeneIDi3606405.
KEGGipmn:PMN2A_1019.
PATRICi23025877. VBIProMar14922_1866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58509.1 .
RefSeqi WP_011295364.1. NC_007335.2.
YP_292212.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46J19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ58509 ; AAZ58509 ; PMN2A_1019 .
GeneIDi 3606405.
KEGGi pmn:PMN2A_1019.
PATRICi 23025877. VBIProMar14922_1866.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q46J19.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PMAR59920:GI1O-1890-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiHISX_PROMT
AccessioniPrimary (citable) accession number: Q46J19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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