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Q46J19

- HISX_PROMT

UniProt

Q46J19 - HISX_PROMT

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461NADUniRule annotation
    Binding sitei208 – 2081NADUniRule annotation
    Binding sitei231 – 2311NADUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Metal bindingi276 – 2761ZincUniRule annotation
    Binding sitei276 – 2761SubstrateUniRule annotation
    Metal bindingi279 – 2791ZincUniRule annotation
    Binding sitei279 – 2791SubstrateUniRule annotation
    Active sitei344 – 3441Proton acceptorUniRule annotation
    Active sitei345 – 3451Proton acceptorUniRule annotation
    Binding sitei345 – 3451SubstrateUniRule annotation
    Metal bindingi378 – 3781ZincUniRule annotation
    Binding sitei378 – 3781SubstrateUniRule annotation
    Binding sitei432 – 4321SubstrateUniRule annotation
    Metal bindingi437 – 4371ZincUniRule annotation
    Binding sitei437 – 4371SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciPMAR59920:GI1O-1890-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:PMN2A_1019
    OrganismiProchlorococcus marinus (strain NATL2A)
    Taxonomic identifieri59920 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002535: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Histidinol dehydrogenasePRO_0000135815Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59920.PMN2A_1019.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46J19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiQ46J19.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46J19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQIINKDEV QETSSKKLTI KTANSIDQAQ FELRKITERT SGTVQDEAIK    50
    VVDDILKNVR ERGDEALTEY TSRFDGFLTE KFQVSSDLIL KAWEETPREL 100
    QDSLLLAKKR IEKFHSLQVP KNITYTGPNG ETLGRRWSPV EKAGIYVPGG 150
    RAAYPSTVLM NAIPAYVAGV NQIIMVSPAN SQGEINQTVL AAAHITGINK 200
    IFRLGGAQAI CALASGTESI PKVDVITGPG NIYVTLAKKK VYGKVGIDSL 250
    AGPSEILIIA DQSAKLEHVA SDMLAQSEHD PLASAILITT NTKLAEKLPA 300
    EINRQLINHP RLKICQESIS NWGLIVLCDD LETCAQLSDT FAPEHLELLV 350
    EDPKKLSESI NNAGAIFMGP WSPEAIGDYL GGPNHTLPTS GTARFAGALG 400
    VETFMKNTSL IDFSKEAFNE NKNAVVQLAN SEGLHSHAES IRIRDSKSF 449
    Length:449
    Mass (Da):48,862
    Last modified:September 13, 2005 - v1
    Checksum:iE8D895AE8A088870
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ58509.1.
    RefSeqiWP_011295364.1. NC_007335.2.
    YP_292212.1. NC_007335.2.

    Genome annotation databases

    EnsemblBacteriaiAAZ58509; AAZ58509; PMN2A_1019.
    GeneIDi3606405.
    KEGGipmn:PMN2A_1019.
    PATRICi23025877. VBIProMar14922_1866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ58509.1 .
    RefSeqi WP_011295364.1. NC_007335.2.
    YP_292212.1. NC_007335.2.

    3D structure databases

    ProteinModelPortali Q46J19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59920.PMN2A_1019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ58509 ; AAZ58509 ; PMN2A_1019 .
    GeneIDi 3606405.
    KEGGi pmn:PMN2A_1019.
    PATRICi 23025877. VBIProMar14922_1866.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi Q46J19.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci PMAR59920:GI1O-1890-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL2A.

    Entry informationi

    Entry nameiHISX_PROMT
    AccessioniPrimary (citable) accession number: Q46J19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3