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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461NADUniRule annotation
Binding sitei208 – 2081NADUniRule annotation
Binding sitei231 – 2311NADUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Metal bindingi276 – 2761ZincUniRule annotation
Binding sitei276 – 2761SubstrateUniRule annotation
Metal bindingi279 – 2791ZincUniRule annotation
Binding sitei279 – 2791SubstrateUniRule annotation
Active sitei344 – 3441Proton acceptorUniRule annotation
Active sitei345 – 3451Proton acceptorUniRule annotation
Binding sitei345 – 3451SubstrateUniRule annotation
Metal bindingi378 – 3781ZincUniRule annotation
Binding sitei378 – 3781SubstrateUniRule annotation
Binding sitei432 – 4321SubstrateUniRule annotation
Metal bindingi437 – 4371ZincUniRule annotation
Binding sitei437 – 4371SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-1890-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PMN2A_1019
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Histidinol dehydrogenasePRO_0000135815Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_1019.

Structurei

3D structure databases

ProteinModelPortaliQ46J19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ46J19.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46J19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQIINKDEV QETSSKKLTI KTANSIDQAQ FELRKITERT SGTVQDEAIK
60 70 80 90 100
VVDDILKNVR ERGDEALTEY TSRFDGFLTE KFQVSSDLIL KAWEETPREL
110 120 130 140 150
QDSLLLAKKR IEKFHSLQVP KNITYTGPNG ETLGRRWSPV EKAGIYVPGG
160 170 180 190 200
RAAYPSTVLM NAIPAYVAGV NQIIMVSPAN SQGEINQTVL AAAHITGINK
210 220 230 240 250
IFRLGGAQAI CALASGTESI PKVDVITGPG NIYVTLAKKK VYGKVGIDSL
260 270 280 290 300
AGPSEILIIA DQSAKLEHVA SDMLAQSEHD PLASAILITT NTKLAEKLPA
310 320 330 340 350
EINRQLINHP RLKICQESIS NWGLIVLCDD LETCAQLSDT FAPEHLELLV
360 370 380 390 400
EDPKKLSESI NNAGAIFMGP WSPEAIGDYL GGPNHTLPTS GTARFAGALG
410 420 430 440
VETFMKNTSL IDFSKEAFNE NKNAVVQLAN SEGLHSHAES IRIRDSKSF
Length:449
Mass (Da):48,862
Last modified:September 13, 2005 - v1
Checksum:iE8D895AE8A088870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ58509.1.
RefSeqiWP_011295364.1. NC_007335.2.
YP_292212.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ58509; AAZ58509; PMN2A_1019.
KEGGipmn:PMN2A_1019.
PATRICi23025877. VBIProMar14922_1866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ58509.1.
RefSeqiWP_011295364.1. NC_007335.2.
YP_292212.1. NC_007335.2.

3D structure databases

ProteinModelPortaliQ46J19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59920.PMN2A_1019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ58509; AAZ58509; PMN2A_1019.
KEGGipmn:PMN2A_1019.
PATRICi23025877. VBIProMar14922_1866.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ46J19.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciPMAR59920:GI1O-1890-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiHISX_PROMT
AccessioniPrimary (citable) accession number: Q46J19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.