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Q46J13

- IF2_PROMT

UniProt

Q46J13 - IF2_PROMT

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Protein
Translation initiation factor IF-2
Gene
infB, PMN2A_1025
Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi684 – 6918GTP By similarity
Nucleotide bindingi734 – 7385GTP By similarity
Nucleotide bindingi788 – 7914GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-1896-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:PMN2A_1025
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11831183Translation initiation factor IF-2UniRule annotation
PRO_0000228226Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_1025.

Structurei

3D structure databases

ProteinModelPortaliQ46J13.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini675 – 847173tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni684 – 6918G1 By similarity
Regioni709 – 7135G2 By similarity
Regioni734 – 7374G3 By similarity
Regioni788 – 7914G4 By similarity
Regioni824 – 8263G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiQNRQGVP.
OrthoDBiEOG67HJSV.
PhylomeDBiQ46J13.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46J13-1 [UniParc]FASTAAdd to Basket

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MTSSGKIRIY ELSKDLSLDN KDVLDAARKL AIAAKSHSSS ISSLEANQIK     50
DFLKKSNTIN TTIKSSKNLD KQILSVKKNP VKTQKDQKTE PKKKNHDQTE 100
LSQAKLNTLL KPSQTLIKSQ GSSQANNQKA LKNKFPAKQQ ITSPSKPNKP 150
LPPNPRVEVK PIISKPLTQA ERAIPQSEQK KDGQFINQPK RSELAKKSIG 200
QPKQINPQEP KRPLAPPSRP KIDIQDKKPL QPNNQKAKTR INQGEISPQK 250
VGQGNIQKIK SQNKQNAPSR TPQPPTKGNT LELVGAPIRK EKPVNKPHTN 300
EVRNKPVMPS RPGAPKPPTA ANRQGLSNRP GSNNRIGGTG RPGSPNRQGP 350
NRGGVANRTT QGQNRPGANN RAGAPVRSGS PNRGGMQNRP GVPTRSLGGP 400
NRSNNRPGVP SGMRKPVAPS ELMQLQKPQA RPNAPQRKTD SPTSLRPKRE 450
NSTGARPPVN RPTPAAPKKP AHRPGGTAAA PRRTGRPDWD DSAKLDALRN 500
KSPQKQRQKV HIIGENDDAL TAERGGFAGE QQAVVLSASL ARPSKPKVGK 550
RNNGKPLTAL KKRKKETTRQ RQRRRAMELR ASREAKLVRP EMIVVPEDNL 600
TVQELADMLS VESSEIIKSL FFKGITATVT QSLDLATIET VAEEFGVPVL 650
QDDVEEAAKK TVEMIEEGDL KYLIRRPPVV TVMGHVDHGK TSLLDAIRKA 700
RVAAGEAGGI TQHIGAYQIE TEHDGSTKKL TFLDTPGHEA FTAMRARGTR 750
VTDVAILVVA ADDGVRPQTL EAISHARAAK VPIVVAINKI DKEGSSPDRV 800
KQELSEQDLL SEEWGGDVVM VPVSAIKGEN IDKLLEMVLL VTEVEDLQAN 850
PDRLAKGTVI EAHLDKAKGP VATLLVQNGT LKSGDVVAAG PVLGKVRAMV 900
DENGSRIKEA GPSCPVEALG FSEVPTAGDE FEVYPDEKAA RAVVGERATD 950
ARAARLAQQM ASRRVSLSSM SGQASEGELK ELNIILKADV QGSLEAILGS 1000
LEQLPKDEVQ VRVLLSAPGE ITETDIDLAA ASGAVIVGFN TSMASGAKRA 1050
ADANGVDVRE YEVIYKLLED IQLAMEGLLE PEMIEEALGV AEVRAIFSIG 1100
KSAVAGCYVT NGKIQRNCRA RVKRGKQIVF EGDLDSLKRN KDDVKDVSTG 1150
FECGIGCDRF ANWEEGDQIE AFKLVTQRRK LNN 1183
Length:1,183
Mass (Da):128,121
Last modified:September 13, 2005 - v1
Checksum:i7ECFDD0DC206B4C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58515.1.
RefSeqiYP_292218.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ58515; AAZ58515; PMN2A_1025.
GeneIDi3606411.
KEGGipmn:PMN2A_1025.
PATRICi23025889. VBIProMar14922_1872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58515.1 .
RefSeqi YP_292218.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46J13.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ58515 ; AAZ58515 ; PMN2A_1025 .
GeneIDi 3606411.
KEGGi pmn:PMN2A_1025.
PATRICi 23025889. VBIProMar14922_1872.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi QNRQGVP.
OrthoDBi EOG67HJSV.
PhylomeDBi Q46J13.

Enzyme and pathway databases

BioCyci PMAR59920:GI1O-1896-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiIF2_PROMT
AccessioniPrimary (citable) accession number: Q46J13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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