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Q46J13

- IF2_PROMT

UniProt

Q46J13 - IF2_PROMT

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi684 – 6918GTPUniRule annotation
    Nucleotide bindingi734 – 7385GTPUniRule annotation
    Nucleotide bindingi788 – 7914GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59920:GI1O-1896-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:PMN2A_1025
    OrganismiProchlorococcus marinus (strain NATL2A)
    Taxonomic identifieri59920 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11831183Translation initiation factor IF-2PRO_0000228226Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59920.PMN2A_1025.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46J13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini675 – 847173tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni684 – 6918G1By similarity
    Regioni709 – 7135G2By similarity
    Regioni734 – 7374G3By similarity
    Regioni788 – 7914G4By similarity
    Regioni824 – 8263G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiQNRQGVP.
    OrthoDBiEOG67HJSV.
    PhylomeDBiQ46J13.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46J13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSGKIRIY ELSKDLSLDN KDVLDAARKL AIAAKSHSSS ISSLEANQIK     50
    DFLKKSNTIN TTIKSSKNLD KQILSVKKNP VKTQKDQKTE PKKKNHDQTE 100
    LSQAKLNTLL KPSQTLIKSQ GSSQANNQKA LKNKFPAKQQ ITSPSKPNKP 150
    LPPNPRVEVK PIISKPLTQA ERAIPQSEQK KDGQFINQPK RSELAKKSIG 200
    QPKQINPQEP KRPLAPPSRP KIDIQDKKPL QPNNQKAKTR INQGEISPQK 250
    VGQGNIQKIK SQNKQNAPSR TPQPPTKGNT LELVGAPIRK EKPVNKPHTN 300
    EVRNKPVMPS RPGAPKPPTA ANRQGLSNRP GSNNRIGGTG RPGSPNRQGP 350
    NRGGVANRTT QGQNRPGANN RAGAPVRSGS PNRGGMQNRP GVPTRSLGGP 400
    NRSNNRPGVP SGMRKPVAPS ELMQLQKPQA RPNAPQRKTD SPTSLRPKRE 450
    NSTGARPPVN RPTPAAPKKP AHRPGGTAAA PRRTGRPDWD DSAKLDALRN 500
    KSPQKQRQKV HIIGENDDAL TAERGGFAGE QQAVVLSASL ARPSKPKVGK 550
    RNNGKPLTAL KKRKKETTRQ RQRRRAMELR ASREAKLVRP EMIVVPEDNL 600
    TVQELADMLS VESSEIIKSL FFKGITATVT QSLDLATIET VAEEFGVPVL 650
    QDDVEEAAKK TVEMIEEGDL KYLIRRPPVV TVMGHVDHGK TSLLDAIRKA 700
    RVAAGEAGGI TQHIGAYQIE TEHDGSTKKL TFLDTPGHEA FTAMRARGTR 750
    VTDVAILVVA ADDGVRPQTL EAISHARAAK VPIVVAINKI DKEGSSPDRV 800
    KQELSEQDLL SEEWGGDVVM VPVSAIKGEN IDKLLEMVLL VTEVEDLQAN 850
    PDRLAKGTVI EAHLDKAKGP VATLLVQNGT LKSGDVVAAG PVLGKVRAMV 900
    DENGSRIKEA GPSCPVEALG FSEVPTAGDE FEVYPDEKAA RAVVGERATD 950
    ARAARLAQQM ASRRVSLSSM SGQASEGELK ELNIILKADV QGSLEAILGS 1000
    LEQLPKDEVQ VRVLLSAPGE ITETDIDLAA ASGAVIVGFN TSMASGAKRA 1050
    ADANGVDVRE YEVIYKLLED IQLAMEGLLE PEMIEEALGV AEVRAIFSIG 1100
    KSAVAGCYVT NGKIQRNCRA RVKRGKQIVF EGDLDSLKRN KDDVKDVSTG 1150
    FECGIGCDRF ANWEEGDQIE AFKLVTQRRK LNN 1183
    Length:1,183
    Mass (Da):128,121
    Last modified:September 13, 2005 - v1
    Checksum:i7ECFDD0DC206B4C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ58515.1.
    RefSeqiYP_292218.1. NC_007335.2.

    Genome annotation databases

    EnsemblBacteriaiAAZ58515; AAZ58515; PMN2A_1025.
    GeneIDi3606411.
    KEGGipmn:PMN2A_1025.
    PATRICi23025889. VBIProMar14922_1872.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ58515.1 .
    RefSeqi YP_292218.1. NC_007335.2.

    3D structure databases

    ProteinModelPortali Q46J13.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59920.PMN2A_1025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ58515 ; AAZ58515 ; PMN2A_1025 .
    GeneIDi 3606411.
    KEGGi pmn:PMN2A_1025.
    PATRICi 23025889. VBIProMar14922_1872.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi QNRQGVP.
    OrthoDBi EOG67HJSV.
    PhylomeDBi Q46J13.

    Enzyme and pathway databases

    BioCyci PMAR59920:GI1O-1896-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL2A.

    Entry informationi

    Entry nameiIF2_PROMT
    AccessioniPrimary (citable) accession number: Q46J13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3