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Q46J13 (IF2_PROMT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:PMN2A_1025
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length1183 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11831183Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000228226

Regions

Nucleotide binding684 – 6918GTP By similarity
Nucleotide binding734 – 7385GTP By similarity
Nucleotide binding788 – 7914GTP By similarity
Region678 – 830153G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q46J13 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 7ECFDD0DC206B4C0

FASTA1,183128,121
        10         20         30         40         50         60 
MTSSGKIRIY ELSKDLSLDN KDVLDAARKL AIAAKSHSSS ISSLEANQIK DFLKKSNTIN 

        70         80         90        100        110        120 
TTIKSSKNLD KQILSVKKNP VKTQKDQKTE PKKKNHDQTE LSQAKLNTLL KPSQTLIKSQ 

       130        140        150        160        170        180 
GSSQANNQKA LKNKFPAKQQ ITSPSKPNKP LPPNPRVEVK PIISKPLTQA ERAIPQSEQK 

       190        200        210        220        230        240 
KDGQFINQPK RSELAKKSIG QPKQINPQEP KRPLAPPSRP KIDIQDKKPL QPNNQKAKTR 

       250        260        270        280        290        300 
INQGEISPQK VGQGNIQKIK SQNKQNAPSR TPQPPTKGNT LELVGAPIRK EKPVNKPHTN 

       310        320        330        340        350        360 
EVRNKPVMPS RPGAPKPPTA ANRQGLSNRP GSNNRIGGTG RPGSPNRQGP NRGGVANRTT 

       370        380        390        400        410        420 
QGQNRPGANN RAGAPVRSGS PNRGGMQNRP GVPTRSLGGP NRSNNRPGVP SGMRKPVAPS 

       430        440        450        460        470        480 
ELMQLQKPQA RPNAPQRKTD SPTSLRPKRE NSTGARPPVN RPTPAAPKKP AHRPGGTAAA 

       490        500        510        520        530        540 
PRRTGRPDWD DSAKLDALRN KSPQKQRQKV HIIGENDDAL TAERGGFAGE QQAVVLSASL 

       550        560        570        580        590        600 
ARPSKPKVGK RNNGKPLTAL KKRKKETTRQ RQRRRAMELR ASREAKLVRP EMIVVPEDNL 

       610        620        630        640        650        660 
TVQELADMLS VESSEIIKSL FFKGITATVT QSLDLATIET VAEEFGVPVL QDDVEEAAKK 

       670        680        690        700        710        720 
TVEMIEEGDL KYLIRRPPVV TVMGHVDHGK TSLLDAIRKA RVAAGEAGGI TQHIGAYQIE 

       730        740        750        760        770        780 
TEHDGSTKKL TFLDTPGHEA FTAMRARGTR VTDVAILVVA ADDGVRPQTL EAISHARAAK 

       790        800        810        820        830        840 
VPIVVAINKI DKEGSSPDRV KQELSEQDLL SEEWGGDVVM VPVSAIKGEN IDKLLEMVLL 

       850        860        870        880        890        900 
VTEVEDLQAN PDRLAKGTVI EAHLDKAKGP VATLLVQNGT LKSGDVVAAG PVLGKVRAMV 

       910        920        930        940        950        960 
DENGSRIKEA GPSCPVEALG FSEVPTAGDE FEVYPDEKAA RAVVGERATD ARAARLAQQM 

       970        980        990       1000       1010       1020 
ASRRVSLSSM SGQASEGELK ELNIILKADV QGSLEAILGS LEQLPKDEVQ VRVLLSAPGE 

      1030       1040       1050       1060       1070       1080 
ITETDIDLAA ASGAVIVGFN TSMASGAKRA ADANGVDVRE YEVIYKLLED IQLAMEGLLE 

      1090       1100       1110       1120       1130       1140 
PEMIEEALGV AEVRAIFSIG KSAVAGCYVT NGKIQRNCRA RVKRGKQIVF EGDLDSLKRN 

      1150       1160       1170       1180 
KDDVKDVSTG FECGIGCDRF ANWEEGDQIE AFKLVTQRRK LNN 

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References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000095 Genomic DNA. Translation: AAZ58515.1.
RefSeqYP_292218.1. NC_007335.2.

3D structure databases

ProteinModelPortalQ46J13.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59920.PMN2A_1025.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ58515; AAZ58515; PMN2A_1025.
GeneID3606411.
KEGGpmn:PMN2A_1025.
PATRIC23025889. VBIProMar14922_1872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAQNRQGVP.
OrthoDBEOG67HJSV.
PhylomeDBQ46J13.

Enzyme and pathway databases

BioCycPMAR59920:GI1O-1896-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_PROMT
AccessionPrimary (citable) accession number: Q46J13
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries