ID   HEM6_PROMT              Reviewed;         348 AA.
AC   Q46IN4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Coproporphyrinogen-III oxidase, aerobic;
DE            Short=Coproporphyrinogenase;
DE            Short=Coprogen oxidase;
DE            EC=1.3.3.3;
GN   Name=hemF; OrderedLocusNames=PMN2A_1154;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Prochlorophytes; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L.,
RA   Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J.,
RA   Steglich C., Church G.M., Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY: Coproporphyrinogen-III + O(2) + 2 H(+) =
CC       protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
CC   -!- PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis;
CC       protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step
CC       1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aerobic coproporphyrinogen-III oxidase
CC       family.
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DR   EMBL; CP000095; AAZ58644.1; -; Genomic_DNA.
DR   RefSeq; YP_292347.1; -.
DR   GeneID; 3606544; -.
DR   GenomeReviews; CP000095_GR; PMN2A_1154.
DR   KEGG; pmn:PMN2A_1154; -.
DR   HOGENOM; Q46IN4; -.
DR   OMA; Q46IN4; VFKPWCD.
DR   BioCyc; PMAR59920:PMN2A_1154-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004109; F:coproporphyrinogen oxidase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006779; P:porphyrin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00333; -; 1.
DR   InterPro; IPR001260; Coprogen_oxidas.
DR   InterPro; IPR018375; Coproporphyrinogen-3_ox_CS.
DR   Gene3D; G3DSA:3.40.1500.10; Coprogen_oxidas; 1.
DR   PANTHER; PTHR10755; Coprogen_oxidas; 1.
DR   Pfam; PF01218; Coprogen_oxidas; 1.
DR   PIRSF; PIRSF000166; Coproporphyri_ox; 1.
DR   PRINTS; PR00073; COPRGNOXDASE.
DR   PROSITE; PS01021; COPROGEN_OXIDASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Oxidoreductase; Porphyrin biosynthesis.
FT   CHAIN         1    348       Coproporphyrinogen-III oxidase, aerobic.
FT                                /FTId=PRO_1000019481.
SQ   SEQUENCE   348 AA;  39776 MW;  CCF9C354463225AA CRC64;
     MSSSQDKANL PANNSRARAK KLVLELQDEI CAGLETIDGE GKFLEESWER PEGGGGRSRV
     LKDGQIFEQG GVNFSEVHGN ELPPSIISQR PEAKGHSWFA TGTSMVLHPK SPYIPTVHLN
     YRYFEAGPVW WFGGGADLTP FYPYLSDTRH FHSCHKNACD TIDKDLHKVF KPWCDEYFFL
     KHRNETRGVG GIFYDYQDGS GLLYKGQNAN GKASKIAKEL GEYSLNWENL FSLAKACGQA
     FLPSYEPIIK KRKNQSFSTK ERDFQLYRRG RYAEFNLVWD RGTIFGLQTN GRTESILMSL
     PPLARWEYGY KPEENSREAL LTDLFTKPQD WFTDKSLEKR CLTHQALD
//