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Reviewed, UniProtKB/Swiss-Prot Q46IN4 (HEM6_PROMT)

Last modified November 4, 2008. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3
Gene names
Name: hemF
Ordered Locus Names: PMN2A_1154
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

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Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1. HAMAP MF_00333

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the aerobic coproporphyrinogen III oxidase family.

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Ontologies

Keywords

   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

porphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: HAMAP

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Coproporphyrinogen III oxidase, aerobic HAMAP MF_00333
PRO_1000019481

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Sequences

Sequence LengthMass (Da)Tools
Q46IN4-1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: CCF9C354463225AA

FASTA34839,776
        10         20         30         40         50         60 
MSSSQDKANL PANNSRARAK KLVLELQDEI CAGLETIDGE GKFLEESWER PEGGGGRSRV 

        70         80         90        100        110        120 
LKDGQIFEQG GVNFSEVHGN ELPPSIISQR PEAKGHSWFA TGTSMVLHPK SPYIPTVHLN 

       130        140        150        160        170        180 
YRYFEAGPVW WFGGGADLTP FYPYLSDTRH FHSCHKNACD TIDKDLHKVF KPWCDEYFFL 

       190        200        210        220        230        240 
KHRNETRGVG GIFYDYQDGS GLLYKGQNAN GKASKIAKEL GEYSLNWENL FSLAKACGQA 

       250        260        270        280        290        300 
FLPSYEPIIK KRKNQSFSTK ERDFQLYRRG RYAEFNLVWD RGTIFGLQTN GRTESILMSL 

       310        320        330        340 
PPLARWEYGY KPEENSREAL LTDLFTKPQD WFTDKSLEKR CLTHQALD

« Hide

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References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000095 Genomic DNA. Translation: AAZ58644.1.
RefSeqYP_292347.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3606544.
GenomeReviewsGene locus PMN2A_1154 in contig CP000095_GR.
KEGGpmn:PMN2A_1154.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ46IN4.

Enzyme and pathway databases

BioCycPMAR59920:PMN2A_1154-MON.

Family and domain databases

HAMAPMF_00333.
[Tree]
InterProIPR001260. Coprogen_oxidas.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHEM6_PROMT
AccessionPrimary (citable) accession number: Q46IN4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: November 4, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents