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Q46IC1

- GCSP_PROMT

UniProt

Q46IC1 - GCSP_PROMT

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, PMN2A_1267
Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-2163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PMN2A_1267
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei712 – 7121N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi59920.PMN2A_1267.

Structurei

3D structure databases

ProteinModelPortaliQ46IC1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ46IC1.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46IC1-1 [UniParc]FASTAAdd to Basket

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MSKAELKDFT FKSRHIGPTN EDEALMLQHL GYENAEEFIS SVIPNEIFDS    50
ENNGVSIPDG CDQNKALTEI NIISKKNVEH RSLIGLGYHS TVIPPVIQRN 100
VLENPNWYTA YTPYQAEISQ GRLEALFNFQ TLISELTGLP ISNASLLDEA 150
TAAAEAISLS LTVRKNKNAN KFLVDQEILP QTLDVLKTRC EPLGISLEMF 200
DNNNFEIDKN VFGILIQLPG KNGRIWDPTK IINDAHKCNA IVTIAIDPLA 250
QVLIKPMGEF GADIVVGSAQ RFGVPIAFGG PHAAFFATKE IYKRQIPGRI 300
VGQSVDVEGN QALRLALQTR EQHIRRDKAT SNICTAQVLL AVLSSFYAVH 350
HGPKGLKQIA ENVVKYRSNF ESILMNLEYP IEKYSAFDSV DVYCSEASEV 400
IQLASEEGYN LRVLPIGSDF ENAKGFGVTF DELTCDEEIY KLHQILAQVK 450
GKKTHDLSNF IFENASLIDI PLREKSWLEQ SVFNQYQSET DLMRYIHCLV 500
SKDFSLVQGM IPLGSCTMKL NAAAELLPIE WREFSSIHPF APHTQLTGFH 550
EIINDLENWL SALTGFQGVS LQPNAGSQGE FAGLLVIRSW HQSLGEGHRN 600
ICLIPTSAHG TNPASAVMSG FKVVSVKCDE YGNVDLEDLK NKSKIHSKNL 650
AALMVTYPST HGVFEPNIRE MCQVIHQEGG QVYLDGANLN AQVGICRPGS 700
YGIDVCHLNL HKTFSIPHGG GGPGVGPIAV ADHLVPYLPG HSIIKCGGQK 750
AISAVSAAPF GSAGILPISW MYIRMMGSDG LRKASSIAIL SANYLAKRLD 800
PYYPVLFKDP NGLVAHECIL DLRPLKSQLG IEVEDVAKRL MDYGFHAPTI 850
SWPVAGTLMV EPTESESLPE LDRFCDAMIG IREEIEQIKL GKIDPINNPL 900
KQSPHTLKTV TSDDWDRPYS RKEAAYPLPD QEKYKFWPSV SRINNAYGDR 950
NLICSCPSVQ DLEDINSV 968
Length:968
Mass (Da):107,029
Last modified:September 13, 2005 - v1
Checksum:i79DDE59B3D0F6780
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58757.1.
RefSeqiWP_011295611.1. NC_007335.2.
YP_292460.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ58757; AAZ58757; PMN2A_1267.
GeneIDi3606661.
KEGGipmn:PMN2A_1267.
PATRICi23026435. VBIProMar14922_2139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58757.1 .
RefSeqi WP_011295611.1. NC_007335.2.
YP_292460.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46IC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ58757 ; AAZ58757 ; PMN2A_1267 .
GeneIDi 3606661.
KEGGi pmn:PMN2A_1267.
PATRICi 23026435. VBIProMar14922_2139.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q46IC1.

Enzyme and pathway databases

BioCyci PMAR59920:GI1O-2163-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiGCSP_PROMT
AccessioniPrimary (citable) accession number: Q46IC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi