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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-2163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PMN2A_1267
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)PRO_0000227113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei712 – 7121N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ46IC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ46IC1.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46IC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAELKDFT FKSRHIGPTN EDEALMLQHL GYENAEEFIS SVIPNEIFDS
60 70 80 90 100
ENNGVSIPDG CDQNKALTEI NIISKKNVEH RSLIGLGYHS TVIPPVIQRN
110 120 130 140 150
VLENPNWYTA YTPYQAEISQ GRLEALFNFQ TLISELTGLP ISNASLLDEA
160 170 180 190 200
TAAAEAISLS LTVRKNKNAN KFLVDQEILP QTLDVLKTRC EPLGISLEMF
210 220 230 240 250
DNNNFEIDKN VFGILIQLPG KNGRIWDPTK IINDAHKCNA IVTIAIDPLA
260 270 280 290 300
QVLIKPMGEF GADIVVGSAQ RFGVPIAFGG PHAAFFATKE IYKRQIPGRI
310 320 330 340 350
VGQSVDVEGN QALRLALQTR EQHIRRDKAT SNICTAQVLL AVLSSFYAVH
360 370 380 390 400
HGPKGLKQIA ENVVKYRSNF ESILMNLEYP IEKYSAFDSV DVYCSEASEV
410 420 430 440 450
IQLASEEGYN LRVLPIGSDF ENAKGFGVTF DELTCDEEIY KLHQILAQVK
460 470 480 490 500
GKKTHDLSNF IFENASLIDI PLREKSWLEQ SVFNQYQSET DLMRYIHCLV
510 520 530 540 550
SKDFSLVQGM IPLGSCTMKL NAAAELLPIE WREFSSIHPF APHTQLTGFH
560 570 580 590 600
EIINDLENWL SALTGFQGVS LQPNAGSQGE FAGLLVIRSW HQSLGEGHRN
610 620 630 640 650
ICLIPTSAHG TNPASAVMSG FKVVSVKCDE YGNVDLEDLK NKSKIHSKNL
660 670 680 690 700
AALMVTYPST HGVFEPNIRE MCQVIHQEGG QVYLDGANLN AQVGICRPGS
710 720 730 740 750
YGIDVCHLNL HKTFSIPHGG GGPGVGPIAV ADHLVPYLPG HSIIKCGGQK
760 770 780 790 800
AISAVSAAPF GSAGILPISW MYIRMMGSDG LRKASSIAIL SANYLAKRLD
810 820 830 840 850
PYYPVLFKDP NGLVAHECIL DLRPLKSQLG IEVEDVAKRL MDYGFHAPTI
860 870 880 890 900
SWPVAGTLMV EPTESESLPE LDRFCDAMIG IREEIEQIKL GKIDPINNPL
910 920 930 940 950
KQSPHTLKTV TSDDWDRPYS RKEAAYPLPD QEKYKFWPSV SRINNAYGDR
960
NLICSCPSVQ DLEDINSV
Length:968
Mass (Da):107,029
Last modified:September 13, 2005 - v1
Checksum:i79DDE59B3D0F6780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ58757.1.
RefSeqiWP_011295611.1. NC_007335.2.
YP_292460.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ58757; AAZ58757; PMN2A_1267.
KEGGipmn:PMN2A_1267.
PATRICi23026435. VBIProMar14922_2139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ58757.1.
RefSeqiWP_011295611.1. NC_007335.2.
YP_292460.1. NC_007335.2.

3D structure databases

ProteinModelPortaliQ46IC1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ58757; AAZ58757; PMN2A_1267.
KEGGipmn:PMN2A_1267.
PATRICi23026435. VBIProMar14922_2139.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ46IC1.

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-2163-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiGCSP_PROMT
AccessioniPrimary (citable) accession number: Q46IC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: June 24, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.