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Q46IC1

- GCSP_PROMT

UniProt

Q46IC1 - GCSP_PROMT

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-2163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PMN2A_1267
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)PRO_0000227113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei712 – 7121N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi59920.PMN2A_1267.

Structurei

3D structure databases

ProteinModelPortaliQ46IC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ46IC1.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46IC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKAELKDFT FKSRHIGPTN EDEALMLQHL GYENAEEFIS SVIPNEIFDS
60 70 80 90 100
ENNGVSIPDG CDQNKALTEI NIISKKNVEH RSLIGLGYHS TVIPPVIQRN
110 120 130 140 150
VLENPNWYTA YTPYQAEISQ GRLEALFNFQ TLISELTGLP ISNASLLDEA
160 170 180 190 200
TAAAEAISLS LTVRKNKNAN KFLVDQEILP QTLDVLKTRC EPLGISLEMF
210 220 230 240 250
DNNNFEIDKN VFGILIQLPG KNGRIWDPTK IINDAHKCNA IVTIAIDPLA
260 270 280 290 300
QVLIKPMGEF GADIVVGSAQ RFGVPIAFGG PHAAFFATKE IYKRQIPGRI
310 320 330 340 350
VGQSVDVEGN QALRLALQTR EQHIRRDKAT SNICTAQVLL AVLSSFYAVH
360 370 380 390 400
HGPKGLKQIA ENVVKYRSNF ESILMNLEYP IEKYSAFDSV DVYCSEASEV
410 420 430 440 450
IQLASEEGYN LRVLPIGSDF ENAKGFGVTF DELTCDEEIY KLHQILAQVK
460 470 480 490 500
GKKTHDLSNF IFENASLIDI PLREKSWLEQ SVFNQYQSET DLMRYIHCLV
510 520 530 540 550
SKDFSLVQGM IPLGSCTMKL NAAAELLPIE WREFSSIHPF APHTQLTGFH
560 570 580 590 600
EIINDLENWL SALTGFQGVS LQPNAGSQGE FAGLLVIRSW HQSLGEGHRN
610 620 630 640 650
ICLIPTSAHG TNPASAVMSG FKVVSVKCDE YGNVDLEDLK NKSKIHSKNL
660 670 680 690 700
AALMVTYPST HGVFEPNIRE MCQVIHQEGG QVYLDGANLN AQVGICRPGS
710 720 730 740 750
YGIDVCHLNL HKTFSIPHGG GGPGVGPIAV ADHLVPYLPG HSIIKCGGQK
760 770 780 790 800
AISAVSAAPF GSAGILPISW MYIRMMGSDG LRKASSIAIL SANYLAKRLD
810 820 830 840 850
PYYPVLFKDP NGLVAHECIL DLRPLKSQLG IEVEDVAKRL MDYGFHAPTI
860 870 880 890 900
SWPVAGTLMV EPTESESLPE LDRFCDAMIG IREEIEQIKL GKIDPINNPL
910 920 930 940 950
KQSPHTLKTV TSDDWDRPYS RKEAAYPLPD QEKYKFWPSV SRINNAYGDR
960
NLICSCPSVQ DLEDINSV
Length:968
Mass (Da):107,029
Last modified:September 13, 2005 - v1
Checksum:i79DDE59B3D0F6780
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58757.1.
RefSeqiWP_011295611.1. NC_007335.2.
YP_292460.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ58757; AAZ58757; PMN2A_1267.
GeneIDi3606661.
KEGGipmn:PMN2A_1267.
PATRICi23026435. VBIProMar14922_2139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ58757.1 .
RefSeqi WP_011295611.1. NC_007335.2.
YP_292460.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46IC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ58757 ; AAZ58757 ; PMN2A_1267 .
GeneIDi 3606661.
KEGGi pmn:PMN2A_1267.
PATRICi 23026435. VBIProMar14922_2139.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q46IC1.

Enzyme and pathway databases

BioCyci PMAR59920:GI1O-2163-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiGCSP_PROMT
AccessioniPrimary (citable) accession number: Q46IC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3