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Q46IC1 (GCSP_PROMT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PMN2A_1267
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length968 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 968968Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227113

Amino acid modifications

Modified residue7121N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q46IC1 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 79DDE59B3D0F6780

FASTA968107,029
        10         20         30         40         50         60 
MSKAELKDFT FKSRHIGPTN EDEALMLQHL GYENAEEFIS SVIPNEIFDS ENNGVSIPDG 

        70         80         90        100        110        120 
CDQNKALTEI NIISKKNVEH RSLIGLGYHS TVIPPVIQRN VLENPNWYTA YTPYQAEISQ 

       130        140        150        160        170        180 
GRLEALFNFQ TLISELTGLP ISNASLLDEA TAAAEAISLS LTVRKNKNAN KFLVDQEILP 

       190        200        210        220        230        240 
QTLDVLKTRC EPLGISLEMF DNNNFEIDKN VFGILIQLPG KNGRIWDPTK IINDAHKCNA 

       250        260        270        280        290        300 
IVTIAIDPLA QVLIKPMGEF GADIVVGSAQ RFGVPIAFGG PHAAFFATKE IYKRQIPGRI 

       310        320        330        340        350        360 
VGQSVDVEGN QALRLALQTR EQHIRRDKAT SNICTAQVLL AVLSSFYAVH HGPKGLKQIA 

       370        380        390        400        410        420 
ENVVKYRSNF ESILMNLEYP IEKYSAFDSV DVYCSEASEV IQLASEEGYN LRVLPIGSDF 

       430        440        450        460        470        480 
ENAKGFGVTF DELTCDEEIY KLHQILAQVK GKKTHDLSNF IFENASLIDI PLREKSWLEQ 

       490        500        510        520        530        540 
SVFNQYQSET DLMRYIHCLV SKDFSLVQGM IPLGSCTMKL NAAAELLPIE WREFSSIHPF 

       550        560        570        580        590        600 
APHTQLTGFH EIINDLENWL SALTGFQGVS LQPNAGSQGE FAGLLVIRSW HQSLGEGHRN 

       610        620        630        640        650        660 
ICLIPTSAHG TNPASAVMSG FKVVSVKCDE YGNVDLEDLK NKSKIHSKNL AALMVTYPST 

       670        680        690        700        710        720 
HGVFEPNIRE MCQVIHQEGG QVYLDGANLN AQVGICRPGS YGIDVCHLNL HKTFSIPHGG 

       730        740        750        760        770        780 
GGPGVGPIAV ADHLVPYLPG HSIIKCGGQK AISAVSAAPF GSAGILPISW MYIRMMGSDG 

       790        800        810        820        830        840 
LRKASSIAIL SANYLAKRLD PYYPVLFKDP NGLVAHECIL DLRPLKSQLG IEVEDVAKRL 

       850        860        870        880        890        900 
MDYGFHAPTI SWPVAGTLMV EPTESESLPE LDRFCDAMIG IREEIEQIKL GKIDPINNPL 

       910        920        930        940        950        960 
KQSPHTLKTV TSDDWDRPYS RKEAAYPLPD QEKYKFWPSV SRINNAYGDR NLICSCPSVQ 


DLEDINSV 

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References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000095 Genomic DNA. Translation: AAZ58757.1.
RefSeqYP_292460.1. NC_007335.2.

3D structure databases

ProteinModelPortalQ46IC1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59920.PMN2A_1267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ58757; AAZ58757; PMN2A_1267.
GeneID3606661.
KEGGpmn:PMN2A_1267.
PATRIC23026435. VBIProMar14922_2139.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycPMAR59920:GI1O-2163-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PROMT
AccessionPrimary (citable) accession number: Q46IC1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families