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Q46HL7

- NADK2_PROMT

UniProt

Q46HL7 - NADK2_PROMT

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Protein

NAD kinase 2

Gene
nadK2, PMN2A_1523
Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptor By similarity
Binding sitei72 – 721NAD By similarity
Binding sitei178 – 1781NAD By similarity
Binding sitei180 – 1801NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NAD By similarity
Nucleotide bindingi148 – 1492NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 2
Gene namesi
Name:nadK2
Ordered Locus Names:PMN2A_1523
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302NAD kinase 2UniRule annotationPRO_0000229673Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_1523.

Structurei

3D structure databases

ProteinModelPortaliQ46HL7.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ46HL7.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46HL7-1 [UniParc]FASTAAdd to Basket

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MTTNLIWILY RSDSDTAYKE TLNCKKIIEG YGKKVLFSEI SNETNNINQL    50
FLKSEVLPEI TIVLGGDGTV LRAARYLSPK NIPILSFNVG GNLGFLTHDR 100
QILKQETFWE RVSNNRFNIQ KRMMLEATVF REKNNNENTI KKSFFALNDF 150
YLRSCTDEIA PTCSLALEID GEAVDRYKGD GLIFSTPTGS TAYSMAAGGP 200
IIHPSLDAII VSAICPMSLA SRPIVVPPES QLVIKPIRGM KQKIKLWLDG 250
SSGCLIEAED TCLIKKSNHS TSIIILDENH SYYKTITQKL HWASSLNNPN 300
KQ 302
Length:302
Mass (Da):33,827
Last modified:September 13, 2005 - v1
Checksum:i96FA882D0436FA18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ59011.1.
RefSeqiWP_011294156.1. NC_007335.2.
YP_292714.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ59011; AAZ59011; PMN2A_1523.
GeneIDi3606921.
KEGGipmn:PMN2A_1523.
PATRICi23022521. VBIProMar14922_0219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ59011.1 .
RefSeqi WP_011294156.1. NC_007335.2.
YP_292714.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46HL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ59011 ; AAZ59011 ; PMN2A_1523 .
GeneIDi 3606921.
KEGGi pmn:PMN2A_1523.
PATRICi 23022521. VBIProMar14922_0219.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.
PhylomeDBi Q46HL7.

Enzyme and pathway databases

BioCyci PMAR59920:GI1O-214-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiNADK2_PROMT
AccessioniPrimary (citable) accession number: Q46HL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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