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Q46HL7

- NADK2_PROMT

UniProt

Q46HL7 - NADK2_PROMT

Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Proton acceptorUniRule annotation
    Binding sitei72 – 721NADUniRule annotation
    Binding sitei178 – 1781NADUniRule annotation
    Binding sitei180 – 1801NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 682NADUniRule annotation
    Nucleotide bindingi148 – 1492NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59920:GI1O-214-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:PMN2A_1523
    OrganismiProchlorococcus marinus (strain NATL2A)
    Taxonomic identifieri59920 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302NAD kinase 2PRO_0000229673Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59920.PMN2A_1523.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46HL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiKLHWAGS.
    OrthoDBiEOG6PZXDR.
    PhylomeDBiQ46HL7.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q46HL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTNLIWILY RSDSDTAYKE TLNCKKIIEG YGKKVLFSEI SNETNNINQL    50
    FLKSEVLPEI TIVLGGDGTV LRAARYLSPK NIPILSFNVG GNLGFLTHDR 100
    QILKQETFWE RVSNNRFNIQ KRMMLEATVF REKNNNENTI KKSFFALNDF 150
    YLRSCTDEIA PTCSLALEID GEAVDRYKGD GLIFSTPTGS TAYSMAAGGP 200
    IIHPSLDAII VSAICPMSLA SRPIVVPPES QLVIKPIRGM KQKIKLWLDG 250
    SSGCLIEAED TCLIKKSNHS TSIIILDENH SYYKTITQKL HWASSLNNPN 300
    KQ 302
    Length:302
    Mass (Da):33,827
    Last modified:September 13, 2005 - v1
    Checksum:i96FA882D0436FA18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ59011.1.
    RefSeqiWP_011294156.1. NC_007335.2.
    YP_292714.1. NC_007335.2.

    Genome annotation databases

    EnsemblBacteriaiAAZ59011; AAZ59011; PMN2A_1523.
    GeneIDi3606921.
    KEGGipmn:PMN2A_1523.
    PATRICi23022521. VBIProMar14922_0219.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ59011.1 .
    RefSeqi WP_011294156.1. NC_007335.2.
    YP_292714.1. NC_007335.2.

    3D structure databases

    ProteinModelPortali Q46HL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59920.PMN2A_1523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ59011 ; AAZ59011 ; PMN2A_1523 .
    GeneIDi 3606921.
    KEGGi pmn:PMN2A_1523.
    PATRICi 23022521. VBIProMar14922_0219.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi KLHWAGS.
    OrthoDBi EOG6PZXDR.
    PhylomeDBi Q46HL7.

    Enzyme and pathway databases

    BioCyci PMAR59920:GI1O-214-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL2A.

    Entry informationi

    Entry nameiNADK2_PROMT
    AccessioniPrimary (citable) accession number: Q46HL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3