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Q46HH8

- PGK_PROMT

UniProt

Q46HH8 - PGK_PROMT

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation
    Binding sitei206 – 2061ATPUniRule annotation
    Binding sitei297 – 2971ATP; via carbonyl oxygenUniRule annotation
    Binding sitei328 – 3281ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi357 – 3604ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59920:GI1O-256-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:PMN2A_1562
    OrganismiProchlorococcus marinus (strain NATL2A)
    Taxonomic identifieri59920 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Phosphoglycerate kinasePRO_1000058032Add
    BLAST

    Proteomic databases

    PRIDEiQ46HH8.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi59920.PMN2A_1562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46HH8.
    SMRiQ46HH8. Positions 1-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingUniRule annotation
    Regioni63 – 664Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiWEALDIG.
    OrthoDBiEOG64N9Z0.
    PhylomeDBiQ46HH8.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46HH8-1 [UniParc]FASTAAdd to Basket

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    MSKRSLSSLG AEDLCGKRVL VRVDFNVPLG DEGLITDDTR IRAALPTIND    50
    LLDKSARVIL SAHFGRPKGQ VNETMRLTAV AQRLSELLGK TVVKTESCIG 100
    AEAKSKVDAM SNGDVVLLEN VRFISGEEKN DTEFAKELAS LAEVYVNDAF 150
    GAAHRAHAST EGVTKFLSPC VAGYLMEKEL KYLQGAIDQP QSPLAAIVGG 200
    SKVSSKIGVL ESLIDKCDKI IVGGGMIFTF YKARGLSVGN SLVEEDKLEL 250
    ASALEKKAQE KGVEFLLPTD VVLADNFSPD ANSKLSKVDA ISEGWMGLDI 300
    GSESVELFQN ALKDCKTVIW NGPMGVFEFE KFANGTNAIA NTLAELSAQG 350
    CCTIIGGGDS VAAVEKAGLA KKMSHISTGG GASLELLEGK VLPGVSALDD 400
    A 401
    Length:401
    Mass (Da):42,359
    Last modified:September 13, 2005 - v1
    Checksum:iA2EC9334AD508DBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ59050.1.
    RefSeqiWP_011294195.1. NC_007335.2.
    YP_292753.1. NC_007335.2.

    Genome annotation databases

    EnsemblBacteriaiAAZ59050; AAZ59050; PMN2A_1562.
    GeneIDi3606960.
    KEGGipmn:PMN2A_1562.
    PATRICi23022599. VBIProMar14922_0258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000095 Genomic DNA. Translation: AAZ59050.1 .
    RefSeqi WP_011294195.1. NC_007335.2.
    YP_292753.1. NC_007335.2.

    3D structure databases

    ProteinModelPortali Q46HH8.
    SMRi Q46HH8. Positions 1-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59920.PMN2A_1562.

    Proteomic databases

    PRIDEi Q46HH8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ59050 ; AAZ59050 ; PMN2A_1562 .
    GeneIDi 3606960.
    KEGGi pmn:PMN2A_1562.
    PATRICi 23022599. VBIProMar14922_0258.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi WEALDIG.
    OrthoDBi EOG64N9Z0.
    PhylomeDBi Q46HH8.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci PMAR59920:GI1O-256-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NATL2A.

    Entry informationi

    Entry nameiPGK_PROMT
    AccessioniPrimary (citable) accession number: Q46HH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3