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Q46HD3

- TRMB_PROMT

UniProt

Q46HD3 - TRMB_PROMT

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351S-adenosyl-L-methionineUniRule annotation
Binding sitei60 – 601S-adenosyl-L-methionineUniRule annotation
Binding sitei87 – 871S-adenosyl-L-methionineUniRule annotation
Active sitei113 – 1131By similarity
Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-305-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:PMN2A_1607
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214tRNA (guanine-N(7)-)-methyltransferasePRO_0000229183Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_1607.

Structurei

3D structure databases

ProteinModelPortaliQ46HD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000237936.
KOiK03439.
OMAiVIQPEFI.
OrthoDBiEOG6K6VBC.
PhylomeDBiQ46HD3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46HD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQHVNPLSQ FFQLPLSLPS KNILFEKSHY PIHLDIGSAK GEFLIELATK
60 70 80 90 100
CPDWNFVGLE IREPLVSLCE KKRRKLELTN LKFLFCNVNV SLDEWLSDLD
110 120 130 140 150
FGQLKRVSIQ FPDPWFKRKH FKRRVLKTNI LNSIAKAMSK NGEIFIQSDI
160 170 180 190 200
FELIEYMTNT IDENRYFTRK NVGDLRSINK NPYNVMTDRE ILSLKKNLLI
210
YRVMYIRNSL LFTN
Length:214
Mass (Da):25,364
Last modified:September 13, 2005 - v1
Checksum:i6DC375BF49429FDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ59095.1.
RefSeqiYP_292798.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ59095; AAZ59095; PMN2A_1607.
GeneIDi3607006.
KEGGipmn:PMN2A_1607.
PATRICi23022697. VBIProMar14922_0306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000095 Genomic DNA. Translation: AAZ59095.1 .
RefSeqi YP_292798.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46HD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ59095 ; AAZ59095 ; PMN2A_1607 .
GeneIDi 3607006.
KEGGi pmn:PMN2A_1607.
PATRICi 23022697. VBIProMar14922_0306.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000237936.
KOi K03439.
OMAi VIQPEFI.
OrthoDBi EOG6K6VBC.
PhylomeDBi Q46HD3.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PMAR59920:GI1O-305-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiTRMB_PROMT
AccessioniPrimary (citable) accession number: Q46HD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3