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Q46HC4 (PTH_PROMT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-tRNA hydrolase

Short name=PTH
EC=3.1.1.29
Gene names
Name:pth
Ordered Locus Names:PMN2A_1616
OrganismProchlorococcus marinus (strain NATL2A) [Complete proteome] [HAMAP]
Taxonomic identifier59920 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP-Rule MF_00083

Catalytic activity

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP-Rule MF_00083

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00083

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00083.

Sequence similarities

Belongs to the PTH family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminoacyl-tRNA hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Peptidyl-tRNA hydrolase HAMAP-Rule MF_00083
PRO_0000264076

Sequences

Sequence LengthMass (Da)Tools
Q46HC4 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 20769B5DCA06EBC4

FASTA20222,873
        10         20         30         40         50         60 
MLSDELKLLV GLGNPGTEYE KTRHNVGFMV LEEIARKNNC SFRESKKLFG RTCEYGSGIE 

        70         80         90        100        110        120 
KTRLLMPNTY MNESGKSVRS AKDWFDFQNN QLIVLVDDMD LPLGKIRVRS KGSSGGHNGL 

       130        140        150        160        170        180 
KSIINHLGTA EFKRLKIGIG APSNDQQERK SKTVSHVLGR FSKEEFIILN FIIQEIISCI 

       190        200 
ESITSNNWEK ISTRLNSYKP DN 

« Hide

References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NATL2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000095 Genomic DNA. Translation: AAZ59104.1.
RefSeqYP_292807.1. NC_007335.2.

3D structure databases

ProteinModelPortalQ46HC4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59920.PMN2A_1616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ59104; AAZ59104; PMN2A_1616.
GeneID3607015.
KEGGpmn:PMN2A_1616.
PATRIC23022715. VBIProMar14922_0315.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0193.
HOGENOMHOG000004797.
KOK01056.
OMAAMHRLHS.
OrthoDBEOG6C5RTR.
PhylomeDBQ46HC4.

Enzyme and pathway databases

BioCycPMAR59920:GI1O-314-MONOMER.

Family and domain databases

Gene3D3.40.50.1470. 1 hit.
HAMAPMF_00083. Pept_tRNA_hydro_bact.
InterProIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERPTHR17224. PTHR17224. 1 hit.
PfamPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMSSF53178. SSF53178. 1 hit.
TIGRFAMsTIGR00447. pth. 1 hit.
PROSITEPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTH_PROMT
AccessionPrimary (citable) accession number: Q46HC4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families