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Q46HA8

- PUR9_PROMT

UniProt

Q46HA8 - PUR9_PROMT

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Prochlorococcus marinus (strain NATL2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMAR59920:GI1O-331-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:PMN2A_1632
OrganismiProchlorococcus marinus (strain NATL2A)
Taxonomic identifieri59920 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002535: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Bifunctional purine biosynthesis protein PurHPRO_1000018934Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59920.PMN2A_1632.

Structurei

3D structure databases

ProteinModelPortaliQ46HA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ46HA8.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46HA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPIALLSVS DKTGLIPLAK ALVNDLGFKI ISSGGTAKLI ESENLPVTRV
60 70 80 90 100
ADYTGFPEIL GGRVKTLNPK IHGGILARRD KQSHLDDLDK QNINPIDLVV
110 120 130 140 150
VNLYPFVKTI SKENVSWEEA IENIDIGGPT MIRAAAKNHQ DVLVVTDPSQ
160 170 180 190 200
YSNLIDAYKS KKITTELRKK YSQQAFEHTA TYDLTISNWI ANQSSSKKVS
210 220 230 240 250
WLQSLPLKQE LRYGENPHQK ASWYGEPEKG WSGANQLQGK ELSTNNLLDL
260 270 280 290 300
EAALSTLREF GYKNNISNPS YQKAAVVIKH TNPCGVAIGD SPSSALKRAL
310 320 330 340 350
DGDRVSAFGG IIAINCPVDE AAAKEIENIF IECVVAPYFD ETAKEILSKK
360 370 380 390 400
KNLRLLELKA ESVQKADKNH IRSILGGLLI QDLDEPSIDQ KKWKSVTELI
410 420 430 440 450
PTDEEMNDLS FAWKIVKHIR SNAIAVASNQ QSLGIGAGQM NRVGSAKLAL
460 470 480 490 500
EAAGTKSKGA VLASDGFFPF DDTVKMASDY GISSIIQPGG SIRDEDSIKA
510
CNELGIKMIL TGKRHFLH
Length:518
Mass (Da):56,649
Last modified:September 13, 2005 - v1
Checksum:iA2B43068CABC44AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ59120.1.
RefSeqiYP_292823.1. NC_007335.2.

Genome annotation databases

EnsemblBacteriaiAAZ59120; AAZ59120; PMN2A_1632.
GeneIDi3607032.
KEGGipmn:PMN2A_1632.
PATRICi23022749. VBIProMar14922_0331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000095 Genomic DNA. Translation: AAZ59120.1 .
RefSeqi YP_292823.1. NC_007335.2.

3D structure databases

ProteinModelPortali Q46HA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59920.PMN2A_1632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ59120 ; AAZ59120 ; PMN2A_1632 .
GeneIDi 3607032.
KEGGi pmn:PMN2A_1632.
PATRICi 23022749. VBIProMar14922_0331.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.
PhylomeDBi Q46HA8.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMAR59920:GI1O-331-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NATL2A.

Entry informationi

Entry nameiPUR9_PROMT
AccessioniPrimary (citable) accession number: Q46HA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3