Q46GC2 (KCY_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	Mbar_A0083

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00239
Subcellular location	Cytoplasm By similarity HAMAP MF_00239.
Sequence similarities	Belongs to the cytidylate kinase family. Type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Cytidylate kinase HAMAP MF_00239		PRO_1000005671
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46GC2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: BB50301ABC2F032E	FASTA	180	20,736
	10 20 30 40 50 60 MRITVSGLPG SGTTTVSKLL AEYYELELIS SGEIFRRIAR EKEMSLAEFG AMAEKDPSID 70 80 90 100 110 120 LAIDKNQREV IHSHEKLILE SRLAGHMAKE VPNVLKIWIK APLPVRVKRI LRREKSVSFD 130 140 150 160 170 180 EELERTVERE KSEALRYMNY YNIDIDDLSI YDIVIDSEKW NQYQILDILK VAIDSLVGPE

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ69070.1.
RefSeq	YP_303650.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46GC2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46GC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3627578.
GenomeReviews	Gene locus Mbar_A0083 in contig CP000099_GR.
KEGG	mba:Mbar_A0083.
NMPDR	fig|269797.3.peg.29.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10101.
HOGENOM	HBG578180.
OMA	CAGFIFR.
ProtClustDB	PRK04182.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A0083-MONOMER.
Family and domain databases
HAMAP	MF_00239. Cytidyl_kinase_type2. [Tree]
InterPro	IPR011892. Cyt_kin_arch. [Graphical view]
KO	K00945.
TIGRFAMs	TIGR02173. Cyt_kin_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_METBF

Accession

Primary (citable) accession number: Q46GC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program