Reviewed,
UniProtKB/Swiss-Prot Q46FV4 (MER_METBF)
Last modified
November 4, 2008.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 5,10-methylenetetrahydromethanopterin reductase EC=1.5.99.11 Alternative name(s): Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase Methylene-H(4)MPT reductase | ||||
| Gene names |
| ||||
| Organism | Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 269797 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributes
| Sequence length | 328 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT By similarity. |
| Catalytic activity | 5-methyltetrahydromethanopterin + coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420. HAMAP MF_01091 |
| Pathway | One-carbon metabolism; methanogenesis from carbone dioxide; methyl-CoM from 5,10-methylene-H(4)MPT: step 1/2. HAMAP MF_01091 |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the mer family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Methanogenesis One-carbon metabolism |
| Cellular component | Cytoplasm |
| Molecular function | Oxidoreductase |
| Technical term | 3D-structure Complete proteome |
Gene Ontology (GO) | |
| Biological process | methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: HAMAP |
| Molecular function | coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 328 | 328 | 5,10-methylenetetrahydromethanopterin reductase HAMAP MF_01091 | PRO_1000064889 | |||
Sequences
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References
| [1] | "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CP000099 Genomic DNA. Translation: AAZ69238.1. | |||||||||||||
| RefSeq | YP_303818.1. | ||||||||||||
3D structure databases | |||||||||||||
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| SMR | Q46FV4. Positions 1-327. | ||||||||||||
| ModBase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 3624867. | ||||||||||||
| GenomeReviews | Gene locus Mbar_A0254 in contig CP000099_GR. | ||||||||||||
| KEGG | mba:Mbar_A0254. | ||||||||||||
| NMPDR | fig|269797.3.peg.370. | ||||||||||||
Organism-specific databases | |||||||||||||
| CMR | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | Q46FV4. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | MBAR269797:MBAR_A0254-MON. | ||||||||||||
Family and domain databases | |||||||||||||
| HAMAP | MF_01091. [Tree] | ||||||||||||
| InterPro | IPR011251. Luciferase-like_bac. IPR016048. Luciferase_mOase. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.20.20.30. Luciferase_like. 1 hit. | ||||||||||||
| Pfam | PF00296. Bac_luciferase. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | MER_METBF | ||||||||
| Accession | Primary (citable) accession number: Q46FV4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


