ID   NADM_METBF              Reviewed;         173 AA.
AC   Q46FV2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Nicotinamide-nucleotide adenylyltransferase;
DE            EC=2.7.7.1;
DE   AltName: Full=NAD(+) pyrophosphorylase;
DE   AltName: Full=NAD(+) diphosphorylase;
DE   AltName: Full=NMN adenylyltransferase;
GN   OrderedLocusNames=Mbar_A0256;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980466; DOI=10.1128/JB.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P.,
RA   Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R.,
RA   Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + nicotinamide ribonucleotide =
CC       diphosphate + NAD(+).
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from
CC       nicotinamide ribonucleotide: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the archaeal NMN adenylyltransferase
CC       family.
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DR   EMBL; CP000099; AAZ69240.1; -; Genomic_DNA.
DR   RefSeq; YP_303820.1; -.
DR   GeneID; 3624869; -.
DR   GenomeReviews; CP000099_GR; Mbar_A0256.
DR   KEGG; mba:Mbar_A0256; -.
DR   NMPDR; fig|269797.3.peg.372; -.
DR   HOGENOM; Q46FV2; -.
DR   OMA; Q46FV2; IGRFQPY.
DR   BioCyc; MBAR269797:MBAR_A0256-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase...; IEA:HAMAP.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00243; -; 1.
DR   InterPro; IPR004821; Cyt_trans_rel.
DR   InterPro; IPR004820; Cytidylyltransf.
DR   InterPro; IPR006418; NMN_Atrans_arc.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   Pfam; PF01467; CTP_transf_2; 1.
DR   TIGRFAMs; TIGR01527; arch_NMN_Atrans; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; NAD; Nucleotide-binding;
KW   Nucleotidyltransferase; Pyridine nucleotide biosynthesis; Transferase.
FT   CHAIN         1    173       Nicotinamide-nucleotide
FT                                adenylyltransferase.
FT                                /FTId=PRO_1000005735.
SQ   SEQUENCE   173 AA;  19899 MW;  5CEFECD3F06E109C CRC64;
     MTRAFYIGRF QPYHFGHHTI IKQIAEEVDE LVVGIGSAQK SHESTDPFTA GERVLMVYNA
     LENLPIRHYV LPIEDIKYNS IWVHHVASRT PHFEVVYSNN PLVIQLFREA GVCVKQSPLY
     IRERYSGTEI RRRMIAGEKW EHLVPKSVVE VIKEIDGVTR LRNVSASDNN SSL
//