Q46FV2 (NADM_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinamide-nucleotide adenylyltransferase
EC=2.7.7.1

Alternative name(s):
NAD(+) diphosphorylase
NAD(+) pyrophosphorylase
NMN adenylyltransferase

Gene names

Ordered Locus Names:

Mbar_A0256

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. HAMAP MF_00243
Subcellular location	Cytoplasm By similarity HAMAP MF_00243.
Sequence similarities	Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinamide-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243		PRO_1000005735

Sequences

	Sequence		Length	Mass (Da)
	Q46FV2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 5CEFECD3F06E109C	FASTA	173	19,899
	10 20 30 40 50 60 MTRAFYIGRF QPYHFGHHTI IKQIAEEVDE LVVGIGSAQK SHESTDPFTA GERVLMVYNA 70 80 90 100 110 120 LENLPIRHYV LPIEDIKYNS IWVHHVASRT PHFEVVYSNN PLVIQLFREA GVCVKQSPLY 130 140 150 160 170 IRERYSGTEI RRRMIAGEKW EHLVPKSVVE VIKEIDGVTR LRNVSASDNN SSL

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ69240.1.
RefSeq	YP_303820.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46FV2.
SMR	Q46FV2. Positions 3-165.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46FV2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3624869.
GenomeReviews	Gene locus Mbar_A0256 in contig CP000099_GR.
KEGG	mba:Mbar_A0256.
NMPDR	fig|269797.3.peg.372.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10577.
HOGENOM	HBG392019.
OMA	FHKGHLE.
ProtClustDB	PRK01153.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A0256-MONOMER.
Family and domain databases
HAMAP	MF_00243. NMN_adenylyltr. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR006418. NMN_Atrans_arc. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00952.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01527. Arch_NMN_Atrans. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADM_METBF

Accession

Primary (citable) accession number: Q46FV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program