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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei176GTPUniRule annotation1
Binding sitei180GTPUniRule annotation1
Binding sitei223GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi58 – 62GTPUniRule annotation5
Nucleotide bindingi145 – 147GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Mbar_A0618Imported
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)Imported
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi269797.Mbar_A0618

Structurei

3D structure databases

ProteinModelPortaliQ46EU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 241TubulinInterPro annotationAdd BLAST192
Domaini243 – 360Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46EU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIVEEALA RSAQEGRAGQ SEYSNLDYSN VVDSDVDAEL EEILRSLKTT
60 70 80 90 100
IKVIGCGGGG SNSIQRMMGE GIQGADLVAL NTDAQHLLHI RSGKKILIGK
110 120 130 140 150
KKTRGLGAGS LPQIGEDAAI ESIDEINSVV EGSDMVFITA GLGGGTGTGS
160 170 180 190 200
APIVAEAARD AGALTIAVVT LPFSVEGHVR RTNAEAGLER LRDVADTVIV
210 220 230 240 250
VPNDKLIEVV PRLPLQAAFK VSDEVLMRAV KGITELITKP GLVNLDFADI
260 270 280 290 300
RTVMQNGGVA MIGLGESDGE NKAVESVQKA LRSPLLDVDI SGATSALVNV
310 320 330 340 350
VGGPDMTISE AESVVQEVYN RIDANARLIW GAQVDPDLEQ TVRTMIVVTG
360 370
VTSAQIYGHG NDKDIAFKYG IDFVE
Length:375
Mass (Da):39,474
Last modified:September 13, 2005 - v1
Checksum:iECAE02F671DD8324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA Translation: AAZ69598.1
RefSeqiWP_011305649.1, NC_007355.1

Genome annotation databases

EnsemblBacteriaiAAZ69598; AAZ69598; Mbar_A0618
GeneIDi3627639
KEGGimba:Mbar_A0618

Similar proteinsi

Entry informationi

Entry nameiQ46EU4_METBF
AccessioniPrimary (citable) accession number: Q46EU4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health