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Q46EL9

- IF5A_METBF

UniProt

Q46EL9 - IF5A_METBF

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Protein
Translation initiation factor 5A
Gene
eif5a, Mbar_A0695
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Functions by promoting the formation of the first peptide bond By similarity.UniRule annotation

GO - Molecular functioni

  1. ribosome binding Source: InterPro
  2. translation elongation factor activity Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
  2. positive regulation of translational elongation Source: InterPro
  3. positive regulation of translational termination Source: InterPro
  4. translational frameshifting Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciMBAR269797:GHUW-710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 5A
Alternative name(s):
Hypusine-containing protein
eIF-5A
Gene namesi
Name:eif5a
Ordered Locus Names:Mbar_A0695
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000008156: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Translation initiation factor 5AUniRule annotation
PRO_0000259437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351Hypusine By similarity

Keywords - PTMi

Hypusine

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A0695.

Structurei

3D structure databases

ProteinModelPortaliQ46EL9.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.

Phylogenomic databases

eggNOGiCOG0231.
HOGENOMiHOG000106269.
KOiK03263.
OMAiKRSIVQP.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00085. eIF_5A.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46EL9-1 [UniParc]FASTAAdd to Basket

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MKQQVEVKEL KEGKYVIIDD EACVIKSITK SKPGKHGAAK ARVEAIGLFD    50
GQKRSYIGSV ANKIYVPIVE RKTAQVISIT GDITQLMDMG DFSTFEIVVP 100
DEYKDKIKEG EEVSYITALG KIKLDIRT 128
Length:128
Mass (Da):14,238
Last modified:September 13, 2005 - v1
Checksum:i3A6467D6506BC5F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1.
RefSeqiYP_304253.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ69673; AAZ69673; Mbar_A0695.
GeneIDi3625762.
KEGGimba:Mbar_A0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1 .
RefSeqi YP_304253.1. NC_007355.1.

3D structure databases

ProteinModelPortali Q46EL9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 269797.Mbar_A0695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ69673 ; AAZ69673 ; Mbar_A0695 .
GeneIDi 3625762.
KEGGi mba:Mbar_A0695.

Phylogenomic databases

eggNOGi COG0231.
HOGENOMi HOG000106269.
KOi K03263.
OMAi KRSIVQP.

Enzyme and pathway databases

BioCyci MBAR269797:GHUW-710-MONOMER.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00085. eIF_5A.
InterProi IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR11673. PTHR11673. 1 hit.
Pfami PF01287. eIF-5a. 1 hit.
[Graphical view ]
PIRSFi PIRSF003025. eIF5A. 1 hit.
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
    Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
    J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fusaro / DSM 804.

Entry informationi

Entry nameiIF5A_METBF
AccessioniPrimary (citable) accession number: Q46EL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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