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Protein

Translation initiation factor 5A

Gene

eif5a

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions by promoting the formation of the first peptide bond.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 5AUniRule annotation
Alternative name(s):
Hypusine-containing proteinUniRule annotation
eIF-5AUniRule annotation
Gene namesi
Name:eif5aUniRule annotation
Ordered Locus Names:Mbar_A0695
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594371 – 128Translation initiation factor 5AAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35HypusineUniRule annotation1

Keywords - PTMi

Hypusine

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A0695.

Structurei

3D structure databases

ProteinModelPortaliQ46EL9.
SMRiQ46EL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04277. Archaea.
COG0231. LUCA.
HOGENOMiHOG000106269.
KOiK03263.
OMAiQIMDMET.
OrthoDBiPOG093Z0HA5.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00085. eIF_5A. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR013185. Transl_elong_KOW-like.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiView protein in Pfam
PF08207. EFP_N. 1 hit.
PF01287. eIF-5a. 1 hit.
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiView protein in SMART
SM01376. eIF-5a. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiView protein in PROSITE
PS00302. IF5A_HYPUSINE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46EL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQVEVKEL KEGKYVIIDD EACVIKSITK SKPGKHGAAK ARVEAIGLFD
60 70 80 90 100
GQKRSYIGSV ANKIYVPIVE RKTAQVISIT GDITQLMDMG DFSTFEIVVP
110 120
DEYKDKIKEG EEVSYITALG KIKLDIRT
Length:128
Mass (Da):14,238
Last modified:September 13, 2005 - v1
Checksum:i3A6467D6506BC5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1.
RefSeqiWP_011305723.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ69673; AAZ69673; Mbar_A0695.
GeneIDi3625762.
KEGGimba:Mbar_A0695.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIF5A_METBF
AccessioniPrimary (citable) accession number: Q46EL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families