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Protein

Translation initiation factor 5A

Gene

eif5a

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions by promoting the formation of the first peptide bond.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 5AUniRule annotation
Alternative name(s):
Hypusine-containing proteinUniRule annotation
eIF-5AUniRule annotation
Gene namesi
Name:eif5aUniRule annotation
Ordered Locus Names:Mbar_A0695
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002594371 – 128Translation initiation factor 5AAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35HypusineUniRule annotation1

Keywords - PTMi

Hypusine

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A0695.

Structurei

3D structure databases

ProteinModelPortaliQ46EL9.
SMRiQ46EL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04277. Archaea.
COG0231. LUCA.
HOGENOMiHOG000106269.
KOiK03263.
OMAiETYETIT.
OrthoDBiPOG093Z0HA5.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00085. eIF_5A. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR013185. Transl_elong_KOW-like.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiView protein in Pfam
PF08207. EFP_N. 1 hit.
PF01287. eIF-5a. 1 hit.
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiView protein in SMART
SM01376. eIF-5a. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiView protein in PROSITE
PS00302. IF5A_HYPUSINE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46EL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQVEVKEL KEGKYVIIDD EACVIKSITK SKPGKHGAAK ARVEAIGLFD
60 70 80 90 100
GQKRSYIGSV ANKIYVPIVE RKTAQVISIT GDITQLMDMG DFSTFEIVVP
110 120
DEYKDKIKEG EEVSYITALG KIKLDIRT
Length:128
Mass (Da):14,238
Last modified:September 13, 2005 - v1
Checksum:i3A6467D6506BC5F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1.
RefSeqiWP_011305723.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ69673; AAZ69673; Mbar_A0695.
GeneIDi3625762.
KEGGimba:Mbar_A0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1.
RefSeqiWP_011305723.1. NC_007355.1.

3D structure databases

ProteinModelPortaliQ46EL9.
SMRiQ46EL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269797.Mbar_A0695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ69673; AAZ69673; Mbar_A0695.
GeneIDi3625762.
KEGGimba:Mbar_A0695.

Phylogenomic databases

eggNOGiarCOG04277. Archaea.
COG0231. LUCA.
HOGENOMiHOG000106269.
KOiK03263.
OMAiETYETIT.
OrthoDBiPOG093Z0HA5.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00085. eIF_5A. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR013185. Transl_elong_KOW-like.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiView protein in Pfam
PF08207. EFP_N. 1 hit.
PF01287. eIF-5a. 1 hit.
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiView protein in SMART
SM01376. eIF-5a. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiView protein in PROSITE
PS00302. IF5A_HYPUSINE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF5A_METBF
AccessioniPrimary (citable) accession number: Q46EL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: March 15, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.