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Q46EL9

- IF5A_METBF

UniProt

Q46EL9 - IF5A_METBF

Protein

Translation initiation factor 5A

Gene

eif5a

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Functions by promoting the formation of the first peptide bond.UniRule annotation

    GO - Molecular functioni

    1. ribosome binding Source: InterPro
    2. translation elongation factor activity Source: InterPro
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
    2. positive regulation of translational elongation Source: InterPro
    3. positive regulation of translational termination Source: InterPro
    4. translational frameshifting Source: InterPro

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciMBAR269797:GHUW-710-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor 5AUniRule annotation
    Alternative name(s):
    Hypusine-containing proteinUniRule annotation
    eIF-5AUniRule annotation
    Gene namesi
    Name:eif5aUniRule annotation
    Ordered Locus Names:Mbar_A0695
    OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
    Taxonomic identifieri269797 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000008156: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128128Translation initiation factor 5APRO_0000259437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351HypusineUniRule annotation

    Keywords - PTMi

    Hypusine

    Interactioni

    Protein-protein interaction databases

    STRINGi269797.Mbar_A0695.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46EL9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-5A family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0231.
    HOGENOMiHOG000106269.
    KOiK03263.
    OMAiKRSIVQP.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00085. eIF_5A.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR022847. Transl_elong_IF5A_arc.
    IPR020189. Transl_elong_IF5A_C.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR11673. PTHR11673. 1 hit.
    PfamiPF01287. eIF-5a. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003025. eIF5A. 1 hit.
    SUPFAMiSSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
    PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46EL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQQVEVKEL KEGKYVIIDD EACVIKSITK SKPGKHGAAK ARVEAIGLFD    50
    GQKRSYIGSV ANKIYVPIVE RKTAQVISIT GDITQLMDMG DFSTFEIVVP 100
    DEYKDKIKEG EEVSYITALG KIKLDIRT 128
    Length:128
    Mass (Da):14,238
    Last modified:September 13, 2005 - v1
    Checksum:i3A6467D6506BC5F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000099 Genomic DNA. Translation: AAZ69673.1.
    RefSeqiYP_304253.1. NC_007355.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ69673; AAZ69673; Mbar_A0695.
    GeneIDi3625762.
    KEGGimba:Mbar_A0695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000099 Genomic DNA. Translation: AAZ69673.1 .
    RefSeqi YP_304253.1. NC_007355.1.

    3D structure databases

    ProteinModelPortali Q46EL9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269797.Mbar_A0695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ69673 ; AAZ69673 ; Mbar_A0695 .
    GeneIDi 3625762.
    KEGGi mba:Mbar_A0695.

    Phylogenomic databases

    eggNOGi COG0231.
    HOGENOMi HOG000106269.
    KOi K03263.
    OMAi KRSIVQP.

    Enzyme and pathway databases

    BioCyci MBAR269797:GHUW-710-MONOMER.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00085. eIF_5A.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR022847. Transl_elong_IF5A_arc.
    IPR020189. Transl_elong_IF5A_C.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR11673. PTHR11673. 1 hit.
    Pfami PF01287. eIF-5a. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003025. eIF5A. 1 hit.
    SUPFAMi SSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
    PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
      Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
      J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fusaro / DSM 804.

    Entry informationi

    Entry nameiIF5A_METBF
    AccessioniPrimary (citable) accession number: Q46EL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3