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Q46EL9

- IF5A_METBF

UniProt

Q46EL9 - IF5A_METBF

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Protein

Translation initiation factor 5A

Gene

eif5a

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Functions by promoting the formation of the first peptide bond.UniRule annotation

GO - Molecular functioni

  1. ribosome binding Source: InterPro
  2. translation elongation factor activity Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
  2. positive regulation of translational elongation Source: InterPro
  3. positive regulation of translational termination Source: InterPro
  4. translational frameshifting Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciMBAR269797:GHUW-710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 5AUniRule annotation
Alternative name(s):
Hypusine-containing proteinUniRule annotation
eIF-5AUniRule annotation
Gene namesi
Name:eif5aUniRule annotation
Ordered Locus Names:Mbar_A0695
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000008156: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Translation initiation factor 5APRO_0000259437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351HypusineUniRule annotation

Keywords - PTMi

Hypusine

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A0695.

Structurei

3D structure databases

ProteinModelPortaliQ46EL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0231.
HOGENOMiHOG000106269.
KOiK03263.
OMAiKRSIVQP.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00085. eIF_5A.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46EL9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQQVEVKEL KEGKYVIIDD EACVIKSITK SKPGKHGAAK ARVEAIGLFD
60 70 80 90 100
GQKRSYIGSV ANKIYVPIVE RKTAQVISIT GDITQLMDMG DFSTFEIVVP
110 120
DEYKDKIKEG EEVSYITALG KIKLDIRT
Length:128
Mass (Da):14,238
Last modified:September 13, 2005 - v1
Checksum:i3A6467D6506BC5F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1.
RefSeqiWP_011305723.1. NC_007355.1.
YP_304253.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ69673; AAZ69673; Mbar_A0695.
GeneIDi3625762.
KEGGimba:Mbar_A0695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ69673.1 .
RefSeqi WP_011305723.1. NC_007355.1.
YP_304253.1. NC_007355.1.

3D structure databases

ProteinModelPortali Q46EL9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269797.Mbar_A0695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ69673 ; AAZ69673 ; Mbar_A0695 .
GeneIDi 3625762.
KEGGi mba:Mbar_A0695.

Phylogenomic databases

eggNOGi COG0231.
HOGENOMi HOG000106269.
KOi K03263.
OMAi KRSIVQP.

Enzyme and pathway databases

BioCyci MBAR269797:GHUW-710-MONOMER.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00085. eIF_5A.
InterProi IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR11673. PTHR11673. 1 hit.
Pfami PF01287. eIF-5a. 1 hit.
[Graphical view ]
PIRSFi PIRSF003025. eIF5A. 1 hit.
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
    Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
    J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fusaro / DSM 804.

Entry informationi

Entry nameiIF5A_METBF
AccessioniPrimary (citable) accession number: Q46EL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3