Q46EH1 (MSRB_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	Mbar_A0743

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000068278
Sites
	Active site	121	1	Nucleophile By similarity
	Metal binding	49	1	Zinc By similarity
	Metal binding	52	1	Zinc By similarity
	Metal binding	98	1	Zinc By similarity
	Metal binding	101	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q46EH1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: F1089EBB012CFD73	FASTA	142	16,242
	10 20 30 40 50 60 MAQKAVEKSE EEWKKVLTPE QYHVLRQKGT ERPFSGNLYY NKEKGVYTCA ACGQELFSSD 70 80 90 100 110 120 TKFESGTGWP SFYDVISSDR VRLKEDTSYF MNRIEVVCSR CGSHLGHVFE DGPAPTGKRY 130 140 CINSVSLNFK TEEEGKQGEE RM

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ69721.1.
RefSeq	YP_304301.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46EH1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46EH1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3624444.
GenomeReviews	Gene locus Mbar_A0743 in contig CP000099_GR.
KEGG	mba:Mbar_A0743.
NMPDR	fig|269797.3.peg.129.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10043.
HOGENOM	HBG715255.
OMA	SANAIRY.
PhylomeDB	Q46EH1.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A0743-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_METBF

Accession

Primary (citable) accession number: Q46EH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 13, 2005
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program