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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciMBAR269797:GHUW-767-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:Mbar_A0752
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000008156: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000061430Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A0752.

Structurei

3D structure databases

ProteinModelPortaliQ46EG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228599.
KOiK01520.
OMAiWDAGYEG.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46EG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLLSSTELR KLIQATPSLL ENAIDIETQI QPNGLELTLK EVKTIDGSGA
60 70 80 90 100
VDFDNSERQL PDGKTLEFGN DGWIHLPKGI YKVLFNEIVN IPMNLAAIAK
110 120 130 140 150
PRSTLIRCGT TLETAVWDAG YRGRSESMLV VYNTEGFRLK KDARIMQLLF
160 170
YTLGAEVEKG YSGIYQNENT K
Length:171
Mass (Da):19,100
Last modified:September 13, 2005 - v1
Checksum:i23854036D3A59BD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ69730.1.
RefSeqiYP_304310.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ69730; AAZ69730; Mbar_A0752.
GeneIDi3626370.
KEGGimba:Mbar_A0752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ69730.1.
RefSeqiYP_304310.1. NC_007355.1.

3D structure databases

ProteinModelPortaliQ46EG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269797.Mbar_A0752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ69730; AAZ69730; Mbar_A0752.
GeneIDi3626370.
KEGGimba:Mbar_A0752.

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228599.
KOiK01520.
OMAiWDAGYEG.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.
BioCyciMBAR269797:GHUW-767-MONOMER.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
    Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
    J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fusaro / DSM 804.

Entry informationi

Entry nameiDUT_METBF
AccessioniPrimary (citable) accession number: Q46EG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 13, 2005
Last modified: February 4, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.